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Amygdala Effective connectivity Reading the mind in the eyes Theory of mind fMRI Adult Age of Onset Amygdala Asymptomatic Diseases Brain Mapping Cognition Emotions Facial Expression Female Humans Huntington Disease Image Processing Computer-Assisted Male Mental Status Schedule Middle Aged Neural Pathways Neuropsychological Tests Oxygen Photic Stimulation Reaction Time Theory of mind

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is thought to affect about 1 in 1000 people in the UK. ADPKD causes a progressive decline in kidney function, with kidney failure tending to occur in middle age. Children and...

Adolescent Asymptomatic Diseases Blood Pressure Monitoring Ambulatory Child Genetic Testing Humans Hypertension Medical History Taking Monitoring Physiologic Polycystic Kidney Autosomal Dominant Renal Insufficiency Risk Assessment United Kingdom

Adult Asymptomatic Diseases Bangladesh Cholera Family Family Characteristics Female Gene Order Genotype Humans Infant Male Middle Aged Molecular Sequence Data Molecular Typing Polymerase Chain Reaction Sequence Analysis DNA Serotyping Synteny Vibrio cholerae O139 Young Adult

OBJECTIVE: Frontotemporal dementia (FTD) is typically associated with changes in behaviour, language and movement. However, recent studies have shown that patients can also develop an abnormal response to pain, either heightened...

frontotemporal dementia Pain Adult Aged Asymptomatic Diseases Atrophy C9orf72 Protein cerebellum Cerebral Cortex Cohort Studies Corpus Striatum DNA Repeat Expansion Female frontotemporal dementia Humans Logistic Models Magnetic Resonance Imaging Male Middle Aged Mutation Pain Perception Perceptual Disorders Prefrontal Cortex Progranulins Temporal Lobe Thalamus tau Proteins

Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM...

Aptamers collaborative competition human transcriptome arrays Machine Learning plasma proteomics predictive modeling preterm labor and delivery spontaneous preterm birth whole blood transcriptomics Adult Asymptomatic Diseases Biomarkers Blood Proteins Cell-Free Nucleic Acids Crowdsourcing Female Gestational Age Humans Infant Newborn Longitudinal Studies pre-eclampsia Pregnancy premature birth Proteomics ROC Curve Transcriptome

Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for SARS-CoV-2 in April 2020. About 15% (26/169) HCWs with symptoms of coronavirus...

covid-19 SARS-CoV-2 emerging pathogens EPIDEMIOLOGY Global Health human human biology infectious disease Medicine Occupational health Virology Adult Asymptomatic Diseases Betacoronavirus covid-19 COVID-19 Testing Clinical Laboratory Techniques Community-Acquired Infections Contact Tracing Coronavirus Infections Disease Transmission Infectious England Family Characteristics Female Health Personnel Hospital Units Hospitals Teaching Hospitals University Humans infection control Infectious Disease Transmission Patient-to-Professional Male Mass Screening Middle Aged nasopharynx Occupational Diseases Pandemics Patient Admission Pneumonia Viral prevalence Program Evaluation Real-Time Polymerase Chain Reaction SARS-CoV-2 Symptom Assessment

Alzheimer’s disease COGNITIVE IMPAIRMENT Diffusion weighted imaging Magnetic Resonance Imaging neurodegeneration Neuroimaging Preclinical dementia Alzheimer Disease Asymptomatic Diseases Atrophy Biomarkers Connectome Dementia Disease Progression Gray Matter Humans Neuroimaging

Type 1 diabetes, a disease defined by absolute insulin deficiency, is considered a chronic autoimmune disorder resulting from the destruction of insulin-producing pancreatic β-cells. The incidence of childhood-onset type 1...

Asymptomatic Diseases Blood Glucose Blood Glucose Self-Monitoring Diabetes mellitus Type 1 Humans Insulin

Asymptomatic covid-19 Guideline Infection Post-symptomatic presymptomatic SARS-CoV-2 transmission Asymptomatic Diseases Asymptomatic Infections covid-19 Delivery of Health Care Humans Pathologists SARS-CoV-2

There is great interest in blood-based markers of Alzheimer's disease (AD), especially in its pre-symptomatic stages. Therefore, we aimed to identify plasma proteins whose levels associate with potential markers of...

Aged Alzheimer Disease Asymptomatic Diseases Biomarkers Brain Endophenotypes Entorhinal Cortex Female Humans Intracellular Signaling Peptides and Proteins MAP Kinase Kinase 4 Male Middle Aged Neuropsychological Tests Organ Size Protein Serine-Threonine Kinases Twins

BACKGROUND AND AIMS: Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease...

Atherosclerosis Genetic variants Intima-media-thickness Mendelian randomisation Proinsulin SINGLE NUCLEOTIDE POLYMORPHISMS Asymptomatic Diseases Carotid Artery Diseases Carotid Intima-Media Thickness Chromosomes Human Pair 15 Europe Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans Linear Models Male Mendelian Randomization Analysis Phenotype Polymorphism Single Nucleotide Proinsulin Quantitative Trait Loci Risk Factors Vascular Remodeling

INTRODUCTION: The role of positron emission tomography (PET)/computed tomography (CT) in the determination of inflammation in arterial disease is not well defined. This can provide information about arterial wall inflammation in...

Inflammation Microcalcification Peripheral Arterial Disease positron emission tomography Aged Asymptomatic Diseases Carotid Arteries Carotid Artery Diseases Chi-Square Distribution Female Fluorodeoxyglucose F18 Humans Male Plaque Atherosclerotic Positron Emission Tomography Computed Tomography Predictive Value of Tests Prognosis Radiopharmaceuticals

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. Since its first report in December 2019, despite great efforts made in almost every country worldwide, this disease...

Adolescent Adult Aged Antimalarials Antiviral Agents Asymptomatic Diseases Betacoronavirus covid-19 Child Child Preschool China Coronavirus Infections Female Humans Immunologic Factors Infant Infant Newborn Italy Male Middle Aged Pandemics Pneumonia Viral SARS-CoV-2 Young Adult