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Results: 11
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.
Leo Swadling, Mariana O Diniz, Nathalie M Schmidt, Oliver E Amin, Aneesh Chandran, Emily Shaw, Corinna Pade, Joseph M Gibbons, Nina Le Bert, Anthony T Tan, Anna Jeffery-Smith, Cedric CS Tan, Christine YL Tham, Stephanie Kucykowicz, Gloryanne Aidoo-Micah, Joshua Rosenheim, Jessica Davies, Marina Johnson, Melanie P Jensen, George Joy, Laura E McCoy, Ana M Valdes, Benjamin M Chain, David Goldblatt, Daniel M Altmann, Rosemary J Boyton, Charlotte Manisty, Thomas A Treibel, James C Moon, COVIDsortium Investigators, Lucy van Dorp, Francois Balloux, Áine McKnight, Mahdad Noursadeghi, Antonio Bertoletti, Mala K Maini
Jan 28, 2022
Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before...
Presymptomatic, asymptomatic and post-symptomatic transmission of SARS-CoV-2
Moira A Mugglestone, Natasha V Ratnaraja, Aggie Bak, Jasmin Islam, Jennie A Wilson, Jennifer Bostock, Samuel E Moses, James R Price, Michael Weinbren, Heather P Loveday, Lucy Rivett, Simon M Stoneham, A Peter R Wilson
May 12, 2022
Assessing Zika Virus Transmission Within Households During an Outbreak in Martinique, 2015-2016.
Anthony Cousien, Sylvie Abel, Alice Monthieux, Alessio Andronico, Isabelle Calmont, Minerva Cervantes, Raymond Césaire, Pierre Gallian, Xavier de Lamballerie, Cédric Laouénan, Fatiha Najioullah, Sandrine Pierre-François, Mathilde Pircher, Henrik Salje, Quirine A Ten Bosch, André Cabié, Simon Cauchemez
Feb 15, 2021
Since 2015, Zika virus (ZIKV) has caused large epidemics in the Americas. Households are natural targets for control interventions, but quantification of the contribution of household transmission to overall spread is needed to...
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission.
Lucy Rivett, Sushmita Sridhar, Dominic Sparkes, Matthew Routledge, Nick K Jones, Sally Forrest, Jamie Young, Joana Pereira-Dias, William L Hamilton, Mark Ferris, M Estee Torok, Luke Meredith, CITIID-NIHR COVID-19 BioResource Collaboration, Martin D Curran, Stewart Fuller, Afzal Chaudhry, Ashley Shaw, Richard J Samworth, John R Bradley, Gordon Dougan, Kenneth GC Smith, Paul J Lehner, Nicholas J Matheson, Giles Wright, Ian G Goodfellow, Stephen Baker, Michael P Weekes
May 11, 2020
covid-19 SARS-CoV-2 emerging pathogens EPIDEMIOLOGY Global Health human human biology infectious disease Medicine Occupational health Virology Virus Asymptomatic Infections Betacoronavirus covid-19 COVID-19 Testing COVID-19 Vaccines Clinical Laboratory Techniques Coronavirus Infections Female Health Personnel Humans infection control Male Pandemics Pneumonia Viral Real-Time Polymerase Chain Reaction SARS-CoV-2 United Kingdom
Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection.
Nick K Jones, Lucy Rivett, Shaun Seaman, Richard J Samworth, Ben Warne, Chris Workman, Mark Ferris, Jo Wright, Natalie Quinnell, Ashley Shaw, Cambridge COVID-19 Collaboration, Ian G Goodfellow, Paul J Lehner, Rob Howes, Giles Wright, Nicholas J Matheson, Michael P Weekes
Apr 09, 2021
The BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) is being utilised internationally for mass COVID-19 vaccination. Evidence of single-dose protection against symptomatic disease has encouraged some countries to opt for...
Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia.
Thomas C Darton, Liqing Zhou, Christoph J Blohmke, Claire Jones, Claire S Waddington, Stephen Baker, Andrew J Pollard
Apr 10, 2019
BACKGROUND: Improved diagnostics for typhoid are needed; a typhoid controlled human infection model may accelerate their development and translation. Here, we evaluated a blood culture-PCR assay for detecting infection after...
controlled human infection model Diagnostics Febrile disease Polymerase Chain Reaction Salmonella typhi Typhoid Fever Adolescent Adult Asymptomatic Infections Bacteremia blood culture Culture Media DNA Bacterial Female Fever Healthy Volunteers Humans Male Middle Aged Polymerase Chain Reaction Salmonella typhi Sensitivity and Specificity Typhoid Fever Young Adult
SARS-CoV-2 (COVID-19)
Nisha S Mehta, Oliver T Mytton, Edward WS Mullins, Tom A Fowler, Catherine L Falconer, Orla B Murphy, Claudia Langenberg, Wikum JP Jayatunga, Danielle H Eddy, Jonathan S Nguyen-Van-Tam
May 20, 2020
BACKGROUND: Few pediatric cases of coronavirus disease 2019 (COVID-19) have been reported and we know little about the epidemiology in children, although more is known about other coronaviruses. We aimed to understand the...
Pathology caused by persistent murine norovirus infection.
Amita Shortland, James Chettle, Joy Archer, Kathryn Wood, Dalan Bailey, Ian Goodfellow, Barbara A Blacklaws, Jonathan L Heeney
Mar 13, 2020
Subclinical infection of murine norovirus (MNV) was detected in a mixed breeding group of WT and Stat1(-/-) mice with no outward evidence of morbidity or mortality. Investigations revealed the presence of an attenuated MNV...
High rate of subclinical chikungunya virus infection and association of neutralizing antibody with protection in a prospective cohort in the Philippines.
In-Kyu Yoon, Maria Theresa Alera, Catherine B Lago, Ilya A Tac-An, Daisy Villa, Stefan Fernandez, Butsaya Thaisomboonsuk, Chonticha Klungthong, Jens W Levy, John Mark Velasco, Vito G Roque, Henrik Salje, Louis R Macareo, Laura L Hermann, Ananda Nisalak, Anon Srikiatkhachorn
Feb 15, 2021
BACKGROUND: Chikungunya virus (CHIKV) is a globally re-emerging arbovirus for which previous studies have indicated the majority of infections result in symptomatic febrile illness. We sought to characterize the proportion of...
Adolescent Adult Antibodies Neutralizing Antibodies Viral Asia Asymptomatic Infections Base Sequence Caribbean Region Chikungunya Fever Chikungunya virus Child Child Preschool Cohort Studies Enzyme-Linked Immunosorbent Assay Female Genotype Humans Immunoglobulin G Immunoglobulin M Infant Longitudinal Studies Male Middle Aged Neutralization Tests Philippines Phylogeny Prospective Studies Sequence Analysis RNA Young Adult
Estimating infectiousness throughout SARS-CoV-2 infection course.
Terry C Jones, Guido Biele, Barbara Mühlemann, Talitha Veith, Julia Schneider, Jörn Beheim-Schwarzbach, Tobias Bleicker, Julia Tesch, Marie Luisa Schmidt, Leif Erik Sander, Florian Kurth, Peter Menzel, Rolf Schwarzer, Marta Zuchowski, Jörg Hofmann, Andi Krumbholz, Angela Stein, Anke Edelmann, Victor Max Corman, Christian Drosten
May 31, 2021
Two elementary parameters for quantifying viral infection and shedding are viral load and whether samples yield a replicating virus isolate in cell culture. We examined 25,381 cases of severe acute respiratory syndrome...