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Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age.
Laura Davies, Jiawei Jin, Weijin Shen, Hoyee Tsui, Ying Shi, Yanwen Wang, Yanmin Zhang, Guoliang Hao, JingJing Wu, Si Chen, James A Fraser, Nianguo Dong, Vincent Christoffels, Ursula Ravens, Christopher L-H Huang, Henggui Zhang, Elizabeth J Cartwright, Xin Wang, Ming Lei
Oct 19, 2020
BACKGROUND: Atrial fibrillation (AF), often associated with structural, fibrotic change in cardiac tissues involving regulatory signaling mediators, becomes increasingly common with age. In the present study, we explored the...
aging Atrial fibrillation cardiac remodeling Age Factors Aged Angiotensin II Animals Atrial fibrillation Atrial Remodeling Case-Control Studies Cells Cultured Computer Simulation Down-Regulation Female Fibrosis Heart Rate Humans MAP Kinase Kinase 4 Male Mice Mice Knockout Myocytes Cardiac Rats Rats Sprague-Dawley Signal Transduction Transfection Transforming Growth Factor beta1