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Allosteric Targeting of Aurora A Kinase Using Small Molecules
BACKGROUND: Aurora A (AurA) kinase is a key mitotic protein implicated in cancer. Several small molecule inhibitors targeting the ATP binding site of this enzyme are in various stages of clinical development. However, these...
AURKA AurA-TPX2 inhibition Aurora A TPX2 allosteric inhibition Kinase inhibitors proteinprotein
interaction type IV inhibitors. Allosteric Regulation Allosteric Site Anacardic Acids Aurora Kinase A Cell Cycle Proteins Cell Line Tumor Felodipine Humans Microtubule-Associated Proteins Nuclear Proteins Protein Binding Protein Kinase Inhibitors