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Results: 4
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Mingwei Min, Tycho ET Mevissen, Maria De Luca, David Komander, Catherine Lindon
Oct 28, 2015
Anaphase Anaphase-Promoting Complex-Cyclosome Aurora Kinases Cell Cycle Cell Line Tumor HeLa Cells Humans Lysine Proteasome Endopeptidase Complex Protein Processing Post-Translational Proteolysis Ubiquitin Ubiquitin-Conjugating Enzymes Ubiquitination
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Cover Image for Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer. View Article
Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.
Zhi Hu, Jian-Hua Mao, Christina Curtis, Ge Huang, Shenda Gu, Laura Heiser, Marc E Lenburg, James E Korkola, Nora Bayani, Shamith Samarajiwa, Jose A Seoane, Mark A Dane, Amanda Esch, Heidi S Feiler, Nicholas J Wang, Mary Ann Hardwicke, Sylvie Laquerre, Jeff Jackson, Kenneth W Wood, Barbara Weber, Paul T Spellman, Samuel Aparicio, Richard Wooster, Carlos Caldas, Joe W Gray
Oct 18, 2018
BACKGROUND: High mitotic activity is associated with the genesis and progression of many cancers. Small molecule inhibitors of mitotic apparatus proteins are now being developed and evaluated clinically as anticancer agents....
Breast Cancer Mitotic Index Novel therapeutics Predictive biomarker Aurora Kinases Breast Neoplasms Cell Cycle Proteins Cell Line Tumor Cell Proliferation Chromosomal Proteins Non-Histone Female Gene Amplification Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Regulatory Networks Genome Human Humans Kaplan-Meier Estimate Mitosis Prognosis Protein Serine-Threonine Kinases Proto-Oncogene Proteins RNA Interference Small Molecule Libraries Treatment Outcome
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Cover Image for Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells. View Article
Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells.
Y Lin, FM Richards, B-F Krippendorff, JL Bramhall, JA Harrington, TE Bapiro, A Robertson, D Zheleva, DI Jodrell
Feb 12, 2020
BACKGROUND: Amplification of aurora kinase A (AK-A) overrides the mitotic spindle assembly checkpoint, inducing resistance to taxanes. RNA interference targeting AK-A in human pancreatic cancer cell lines enhanced taxane...
Antineoplastic Combined Chemotherapy Protocols Aurora Kinase A Aurora Kinases Bone Marrow Cells Cell Line Tumor Drug Synergism Granulocyte-Macrophage Progenitor Cells Humans Paclitaxel Pancreatic Neoplasms Protein Kinase Inhibitors Protein Serine-Threonine Kinases Stem Cells
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Cover Image for Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. View Article
Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation.
Alexander Samoshkin, Alexei Arnaoutov, Lars ET Jansen, Ilia Ouspenski, Louis Dye, Tatiana Karpova, James McNally, Mary Dasso, Don W Cleveland, Alexander Strunnikov
Dec 18, 2020
Condensins I and II in vertebrates are essential ATP-dependent complexes necessary for chromosome condensation in mitosis. Condensins depletion is known to perturb structure and function of centromeres, however the mechanism of...
Adenosine Triphosphatases Amino Acid Sequence Aurora Kinase B Aurora Kinases Autoantigens Base Sequence Centromere Centromere Protein A Chromatin Chromosomal Proteins Non-Histone DNA Primers DNA-Binding Proteins HeLa Cells Histones Humans Microscopy Electron Transmission Microscopy Fluorescence Mitosis Multiprotein Complexes Protein Serine-Threonine Kinases
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