Search

Animals Axon guidance Axons Carbocyanines Corpus Striatum Dopaminergic Neurons Embryo Mammalian Female Fluorescent Dyes Intracellular Signaling Peptides and Proteins Intravital Microscopy Mice Knockout Microfluidic Analytical Techniques Microinjections Microscopy Confocal Nerve Net Nerve Tissue Proteins Tissue Culture Techniques

Contact repulsion of growing axons is an essential mechanism for spinal nerve patterning. In birds and mammals the embryonic somites generate a linear series of impenetrable barriers, forcing axon growth cones to traverse one...

Axon guidance chicken developmental biology human neuroscience rat repeat patterning somite Spinal nerve Animals Astrocytes Axon guidance Cell Line Chick Embryo Chickens developmental biology Gene Knockdown Techniques Growth Cones Humans Membrane Proteins Neurosciences Nitric oxide Procollagen-Proline Dioxygenase Protein Disulfide-Isomerases Rats Signal Transduction Somites Spinal Nerves

Tissue mechanics is important for development; however, the spatio-temporal dynamics of in vivo tissue stiffness is still poorly understood. We here developed tiv-AFM, combining time-lapse in vivo atomic force microscopy with...

Atomic force microscopy Axon guidance developmental biology durotaxis Mechanics Mechanotransduction physics of living systems Stiffness Xenopus Animals Axons Biomechanical Phenomena Brain Cell Body Cell Count Embryo Nonmammalian Mitosis Optic Tract Retinal Ganglion Cells Xenopus laevis

miRNAs local translation growth cone Axon guidance brain wiring miR-182 Slit2 cofilin

FRAP RNA labeling RNA localization RNA trafficking axon branching Axon guidance local protein synthesis Mitochondria neural wiring Retinotectal projection β-actin Actins Animals Anisomycin Axons Biotin Blastomeres Carbocyanines Cycloheximide Deoxyuracil Nucleotides Embryo Nonmammalian Gene Expression Regulation Developmental In Vitro Techniques Luminescent Proteins Mitochondria Morpholinos Oligonucleotides Antisense Organ Culture Techniques Protein Synthesis Inhibitors RNA Retina Xenopus laevis

RESEARCH ARTICLE developmental biology neuroscience Spinal nerve repeat patterning somite Axon guidance chicken human rat

Animals Axon guidance Biomarkers Brain Cues Fatty Acid-Binding Protein 7 Female Gene Expression Regulation Developmental Immunohistochemistry Mice Mice Inbred C57BL Microscopy Confocal Nerve Crush Nerve Tissue Proteins Optic Chiasm Optic Nerve Injuries PAX2 Transcription Factor Pregnancy Retinal Ganglion Cells

Fetal Alcohol Spectrum Disorder (FASD) describes the range of deficits that arise from prenatal alcohol exposure. When a pregnant mother drinks alcohol, these deficits can present in offspring as physiological abnormalities...

FASD Corpus Callosum Axon guidance guidance cues agenesis Life Sciences Neuroscience and Neurobiology

Animals Axon guidance Axons Biomechanical Phenomena Models Neurological Nerve Net Neurons Xenopus

DCC ESCRT Netrin-1 Axon guidance Endocytosis protein synthesis Animals Axons Endocytosis Endosomal Sorting Complexes Required for Transport Endosomes Gene Knockdown Techniques Growth Cones Nerve Growth Factors Phenotype Protein Biosynthesis RNA Messenger Receptors Cell Surface Retina Retinal Ganglion Cells Tumor Suppressor Proteins Xenopus Proteins Xenopus laevis

Fetal Alcohol Spectrum Disorder (FASD) is characterized by physical and neurological deficits as a result of prenatal alcohol exposure. Exposure to alcohol during fetal development can result in sensory and motor processing...

FASD Axon guidance cerebellum Neuroscience and Neurobiology

Local translation is rapidly regulated by extrinsic signals during neural wiring, but its control mechanisms remain elusive. Here we show that the extracellular cue Sema3A induces an initial burst in local translation that...

PERK Sema3A axon axon branching Axon guidance eIF2B eIF2α local translation Retinal ganglion cell Unfolded Protein Response Animals Axons Eukaryotic Initiation Factor-2 Eukaryotic Initiation Factor-2B Female Male Neurogenesis Phosphorylation Protein Interaction Maps Proteomics Retinal Ganglion Cells Semaphorin-3A Signal Transduction Tissue Culture Techniques Xenopus Proteins Xenopus laevis eIF-2 Kinase

Axonal protein synthesis and degradation are rapidly regulated by extrinsic signals during neural wiring, but the full landscape of proteomic changes remains unknown due to limitations in axon sampling and sensitivity. By...

axon Axon guidance chemotropic response extrinsic cues growth cone local protein synthesis neural wiring pSILAC-SP3 Proteomics Retinal ganglion cell Animals Axons Brain-Derived Neurotrophic Factor Cells Cultured Embryo Nonmammalian Gene Expression Regulation Isotope Labeling Mass Spectrometry Netrin-1 Neuronal Outgrowth Proteome Proteomics Retinal Ganglion Cells Semaphorin-3A Xenopus laevis

Axon guidance Neural circuitry assembly RNA localisation Retinal ganglion cell Retinotectal projection Tctp tpt1 Animals Axons Biomarkers Tumor Blastomeres Cells Cultured Embryo Nonmammalian In Situ Nick-End Labeling Membrane potential Mitochondrial Mitochondria Mitochondrial Dynamics Morpholinos Myeloid Cell Leukemia Sequence 1 Protein Neurogenesis Optic Lobe Nonmammalian Rats Rats Inbred F344 Retina Retinal Ganglion Cells Tumor Protein Translationally-Controlled 1 Visual Pathways Xenopus laevis