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Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS.
Elske HP Franssen, Rong-Rong Zhao, Hiroaki Koseki, Venkateswarlu Kanamarlapudi, Casper C Hoogenraad, Richard Eva, James W Fawcett
May 21, 2015
Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A antagonism.
Animals Apoptosis Axonal Transport Cell Tracking Cholera Toxin Choroidal Neovascularization Diabetes mellitus Experimental Disease Models Animal Gene Expression Regulation HSP27 Heat-Shock Proteins Intravitreal Injections Male Mice Mice Transgenic Phosphorylation Retinal Ganglion Cells Signal Transduction Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-2 p38 Mitogen-Activated Protein Kinases
Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration.
The physical continuity of axons over long cellular distances poses challenges for their maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike other intracellular organelles, this forms a...
Endoplasmic Reticulum neurodegeneration calcium stores Axonal Transport hereditary spastic paraplegia organelle contact sites smooth ER
Published by: Frontiers in neuroscience
Tri-partite complex for axonal transport drug delivery achieves pharmacological effect.
Aaron G Filler, Garth T Whiteside, Mark Bacon, Martyn Frederickson, Franklyn A Howe, Miri D Rabinowitz, Alan J Sokoloff, Terrence W Deacon, Chris Abell, Raj Munglani, John R Griffiths, B Anthony Bell, Andrew ML Lever
Jun 14, 2011
Amines Analgesics Animals Axonal Transport Cell Line Cells Cultured Cricetinae Cyclohexanecarboxylic Acids Dextrans Dose-Response Relationship Drug Drug Delivery Systems Gabapentin Half-Life Macaca fascicularis Models Neurological Nanoparticles Nerve Growth Factor Neurons Pain Polymers Rabbits Rats Rats Sprague-Dawley Wheat Germ Agglutinins gamma-Aminobutyric Acid
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Ya-Cheng Liao, Michael Fernandopulle, GuoZhen Wang, Heejun Choi, Ling Hao, Catherine M Drerup, Seema Qamar, Jonathon Nixon-Abell, Yi Shen, William Meadows, Michele Vendruscolo, Tuomas Knowles, Matthew Nelson, Magda Czekalska, Greta Musteikyte, Rajan Patel, Christina Stephens, Amalia Pasolli, Lucy Forrest, Peter St George-Hyslop, Jennifer Lippincott-Schwartz, Michael E Ward
Sep 04, 2019
Long-distance RNA transport enables local protein synthesis at metabolicallyactive
sites distant from the nucleus. This process ensures an appropriate spatial
organization of proteins, vital to polarized cells such as neurons....
ANXA11 Amyotrophic Lateral Sclerosis local translation lysosome neurodegeneration neuron Organelles contact phase separation RNA granule RNA transport Amyotrophic Lateral Sclerosis Animals Animals Genetically Modified Annexins Axonal Transport Axons Cell Line Tumor Cytoplasmic Granules Female Humans Induced Pluripotent Stem Cells Lysosomes Male Mutation Protein Binding RNA Rats Rats Sprague-Dawley Transfection Zebrafish
ARF6 and Rab11 as intrinsic regulators of axon regeneration.
Adult central nervous system (CNS) axons do not regenerate after injury because of extrinsic inhibitory factors, and a low intrinsic capacity for axon growth. Developing CNS neurons have a better regenerative ability, but lose...
KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons.
Neurons rely heavily on axonal transport to deliver materials from the sites of synthesis to the axon terminals over distances that can be many centimetres long. KIF1A is the neuron-specific kinesin with the fastest reported...
BACE1 KIF1A Axonal Transport live-cell imaging Amyloid Precursor Protein Secretases Animals Aspartic Acid Endopeptidases Axonal Transport Cells Cultured Green Fluorescent Proteins Kinesins Luminescent Proteins Mice Inbred C57BL Microscopy Fluorescence Motor Neurons Nicotinamide-Nucleotide Adenylyltransferase Protein Transport Signal Transduction Superior Cervical Ganglion
Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport.
Robert Adalbert, Stephen Cahalan, Eleanor L Hopkins, Abdulaziz Almuhanna, Andrea Loreto, Erzsébet Pór, Laura Körmöczy, Justin Perkins, Michael P Coleman, Richard J Piercy
Jun 29, 2022
Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons.
Teresa Rodríguez-Martín, Amy M Pooler, Dawn HW Lau, Gábor M Mórotz, Kurt J De Vos, Jonathan Gilley, Michael P Coleman, Diane P Hanger
Jun 18, 2018
Expression of the frontotemporal dementia-related tau mutation, P301L, at physiological levels in adult mouse brain (KI-P301L mice) results in overt hypophosphorylation of tau and age-dependent alterations in axonal...
Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport.
Robert Adalbert, Stefan Milde, Claire Durrant, Kunie Ando, Virginie Stygelbout, Zehra Yilmaz, Stacey Gould, Jean-Pierre Brion, Michael P Coleman
Jul 04, 2018
Alzheimer's Disease Axonal Transport Aβ FTDP-17T Mitochondria P301L mutation aging Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Animals Axonal Transport Brain Disease Models Animal frontotemporal dementia Genetic Association Studies genetic variation Male Mice Inbred C57BL Mice Transgenic Mitochondria Mutation Plaque Amyloid tau Proteins
Selective rab11 transport and the intrinsic regenerative ability of CNS axons.
Hiroaki Koseki, Matteo Donegá, Brian YH Lam, Veselina Petrova, Susan van Erp, Giles SH Yeo, Jessica CF Kwok, Charles ffrench-Constant, Richard Eva, James W Fawcett
May 09, 2018
Neurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains unclear. Using an in-vitro laser axotomy model, we show a progressive decline in the ability of cut CNS axons to form a new growth cone...
The Struggle to Make CNS Axons Regenerate
James W Fawcett
Aug 05, 2019
Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because these act in parallel, no single intervention has been sufficient to enable full regeneration of damaged axons in the adult mammalian...
Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin.
Juan Garrido-Maraver, Ivana Celardo, Ana C Costa, Susann Lehmann, Samantha HY Loh, L Miguel Martins
Feb 27, 2019
Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease.
Abnormalities of the endolysosomal and autophagy systems are found in Alzheimer's disease, but it is not clear whether defects in these systems are a cause or consequence of degenerative processes in the disease. In human...
Alzheimer’s disease Autophagy Axonal Transport endosome live-cell imaging lysosome Alzheimer Disease Amyloid Precursor Protein Secretases Amyloid beta-Protein Precursor Autophagosomes Autophagy Axons CRISPR-Cas Systems Cerebral Cortex Endosomes Humans Lysosomes Mutation Presenilin-1 Protein Processing Post-Translational Proteolysis
Geniculo-Cortical Projection Diversity Revealed within the Mouse Visual Thalamus.
Marcus N Leiwe, Aenea C Hendry, Andrew D Bard, Stephen J Eglen, Andrew S Lowe, Ian D Thompson
Jan 13, 2016
Axonal trafficking of NMNAT2 and its roles in axon growth and survival in vivo.
The NAD-synthesizing enzyme NMNAT2 is critical for axon survival in primary culture and its depletion may contribute to axon degeneration in a variety of neurodegenerative disorders. Here we discuss several recent reports from...
A New Zebrafish Model to Measure Neuronal α-Synuclein Clearance In Vivo
The accumulation and aggregation of α-synuclein (α-SYN) is a common characteristic of synucleinopathies, such as Parkinson’s Disease (PD), Dementia with Lewy Bodies (DLB) or Multiple System Atrophy (MSA). Multiplications of the...
Axonal transport declines with age in two distinct phases separated by a period of relative stability.
Axonal transport is critical for supplying newly synthesized proteins, organelles, mRNAs, and other cargoes from neuronal cell bodies into axons. Its impairment in many neurodegenerative conditions appears likely to contribute...
aging Axon regeneration Axonal Transport Fluorescence live imaging Mitochondrial transport Nicotinamide mononucleotide Adenylyltransferase 2 aging Animals Axonal Transport Axons Female Humans Male Mice Inbred C57BL Mice Transgenic Mitochondria Molecular Imaging Nerve Regeneration Neurodegenerative Diseases Nicotinamide-Nucleotide Adenylyltransferase Optical Imaging Peripheral Nerves Tibial Nerve
Receptor-ligand supplementation via a self-cleaving 2A peptide-based gene therapy promotes CNS axonal transport with functional recovery.
Tasneem Z Khatib, Andrew Osborne, Sujeong Yang, Zara Ali, Wanyi Jia, Ilya Manyakin, Katie Hall, Robert Watt, Peter S Widdowson, Keith R Martin
Jul 05, 2021
Gene replacement approaches are leading to a revolution in the treatment of previously debilitating monogenic neurological conditions. However, the application of gene therapy to complex polygenic conditions has been limited....
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