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Pathogenic Escherichia coli Possess Elevated Growth Rates under Exposure to Sub-Inhibitory Concentrations of Azithromycin
Tran Tuan-Anh, Ha Thanh Tuyen, Nguyen Ngoc Minh Chau, Nguyen Duc Toan, Tran Hanh Triet, Le Minh Triet, Nguyen Hoang Thu Trang, Nguyen Thi Nguyen To, Josefin Bartholdson Scott, Hao Chung The, Duy Pham Thanh, Hannah Clapham, Stephen Baker
Oct 29, 2020
Antimicrobial resistance (AMR) has been identified by the World Health Organization (WHO) as one of the ten major threats to global health. Advances in technology, including whole-genome sequencing, have provided new insights...
Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei.
Jane Hawkey, Kalani Paranagama, Kate S Baker, Rebecca J Bengtsson, François-Xavier Weill, Nicholas R Thomson, Stephen Baker, Louise Cerdeira, Zamin Iqbal, Martin Hunt, Danielle J Ingle, Timothy J Dallman, Claire Jenkins, Deborah A Williamson, Kathryn E Holt
May 17, 2021
Shigella sonnei is the most common agent of shigellosis in high-income countries, and causes a significant disease burden in low- and middle-income countries. Antimicrobial resistance is increasingly common in all settings....
Anti-Bacterial Agents Australia Azithromycin ciprofloxacin Drug Resistance Multiple Bacterial dysentery Bacillary England Genetics Population Genome Bacterial Genomics Genotype Geography Global Health Humans Microbial Sensitivity Tests Phylogeny Polymorphism Single Nucleotide Shigella sonnei United States whole genome sequencing
Azithromycin Resistance in Shigella spp. in Southeast Asia.
Thomas C Darton, Ha Thanh Tuyen, Hao Chung The, Paul N Newton, David AB Dance, Rattanaphone Phetsouvanh, Viengmon Davong, James I Campbell, Nguyen Van Minh Hoang, Guy E Thwaites, Christopher M Parry, Duy Pham Thanh, Stephen Baker
Apr 10, 2019
Infection by Shigella spp. is a common cause of dysentery in Southeast Asia. Antimicrobials are thought to be beneficial for treatment; however, antimicrobial resistance in Shigella spp. is becoming widespread. We aimed to...
Azithromycin and cefixime combination versus azithromycin alone for the out-patient treatment of clinically suspected or confirmed uncomplicated typhoid fever in South Asia
Abhishek Giri, Abhilasha Karkey, Sabina Dongol, Amit Arjyal, Archana Maharjan, Balaji Veeraraghavan, Buddhi Paudyal, Christiane Dolecek, Damodar Gajurel, Dung Nguyen Thi Phuong, Duy Pham Thanh, Farah Qamar, Gagandeep Kang, Ho Van Hien, Jacob John, Katrina Lawson, Marcel Wolbers, Md Shabab Hossain, M Sharifuzzaman, Nantasit Luangasanatip, Nhukesh Maharjan, Piero Olliaro, Priscilla Rupali, Ronas Shakya, Sadia Shakoor, Samita Rijal, Sonia Qureshi, Stephen Baker, Subi Joshi, Tahmeed Ahmed, Thomas Darton, Tran Nguyen Bao, Yoel Lubell, Evelyne Kestelyn, Guy Thwaites, Christopher M Parry, Buddha Basnyat
Mar 05, 2022
Background: Typhoid and paratyphoid fever (enteric fever) is a common cause of non-specific febrile infection in adults and children presenting to health care facilities in low resource settings such as the South Asia. A 7-day...
Co-trimoxazole versus azithromycin for the treatment of undifferentiated febrile illness in Nepal
Sunil Pokharel, Buddha Basnyat, Amit Arjyal, Saruna Pathak Mahat, Raj Kumar Kc, Abhusani Bhuju, Buddhi Poudyal, Evelyne Kestelyn, Ritu Shrestha, Dung Nguyen Thi Phuong, Rajkumar Thapa, Manan Karki, Sabina Dongol, Abhilasha Karkey, Marcel Wolbers, Stephen Baker, Guy Thwaites
Apr 10, 2019
BACKGROUND: Undifferentiated febrile illness (UFI) includes typhoid and typhus fevers and generally designates fever without any localizing signs. UFI is a great therapeutic challenge in countries like Nepal because of the lack...
Azithromycin Co-trimoxazole enteric fever Fever clearance time Undifferentiated febrile illness Administration Oral Adolescent Adult Aged Anti-Bacterial Agents Azithromycin Child Child Preschool Clinical Protocols Double-Blind Method Drug Resistance Bacterial Female Fever Humans Male Middle Aged Nepal Research Design Time Factors Treatment Outcome Trimethoprim Sulfamethoxazole Drug Combination Typhoid Fever Typhus Epidemic Louse-Borne Young Adult
Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei.
Jane Hawkey, Kalani Paranagama, Kate S Baker, Rebecca J Bengtsson, François-Xavier Weill, Nicholas R Thomson, Stephen Baker, Louise Cerdeira, Zamin Iqbal, Martin Hunt, Danielle J Ingle, Timothy J Dallman, Claire Jenkins, Deborah A Williamson, Kathryn E Holt
Jun 12, 2021
Shigella sonnei is the most common agent of shigellosis in high-income countries, and causes a significant disease burden in low- and middle-income countries. Antimicrobial resistance is increasingly common in all settings....
Humans Shigella sonnei dysentery Bacillary Azithromycin ciprofloxacin Anti-Bacterial Agents Microbial Sensitivity Tests Genetics Population Genomics Phylogeny Drug Resistance Multiple Bacterial Genotype Polymorphism Single Nucleotide Genome Bacterial Geography United States Australia England Global Health whole genome sequencing
Published by: Nature Communications
Pathogenic Escherichia coli Possess Elevated Growth Rates under Exposure to Sub-Inhibitory Concentrations of Azithromycin.
Tran Tuan-Anh, Ha Thanh Tuyen, Nguyen Ngoc Minh Chau, Nguyen Duc Toan, Tran Hanh Triet, Le Minh Triet, Nguyen Hoang Thu Trang, Nguyen Thi Nguyen To, Josefin Bartholdson Scott, Hao Chung The, Duy Pham Thanh, Hannah Clapham, Stephen Baker
Dec 07, 2020
Antimicrobial resistance (AMR) has been identified by the World Health Organization (WHO) as one of the ten major threats to global health. Advances in technology, including whole-genome sequencing, have provided new insights...
Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance
Corinne N Thompson, Abhilasha Karkey, Sabina Dongol, Amit Arjyal, Marcel Wolbers, Thomas Darton, Jeremy J Farrar, Guy E Thwaites, Christiane Dolecek, Buddha Basnyat, Stephen Baker
Apr 10, 2019
BACKGROUND.: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading cause of bacterial febrile disease in South Asia. METHODS.: Individual data from 2092 patients with enteric fever randomized into...
Nepal Antimicrobial resistance enteric fever fluoroquinolone typhoid Adolescent Adult Anti-Bacterial Agents Azithromycin Ceftriaxone Child Drug Resistance Multiple Bacterial Female Fluoroquinolones Gatifloxacin Humans Male Microbial Sensitivity Tests Nepal Ofloxacin Paratyphoid Fever Salmonella paratyphi A Salmonella typhi Treatment Failure Treatment Outcome Typhoid Fever Young Adult
An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation.
Sandra Van Puyvelde, Derek Pickard, Koen Vandelannoote, Eva Heinz, Barbara Barbé, Tessa de Block, Simon Clare, Eve L Coomber, Katherine Harcourt, Sushmita Sridhar, Emily A Lees, Nicole E Wheeler, Elizabeth J Klemm, Laura Kuijpers, Lisette Mbuyi Kalonji, Marie-France Phoba, Dadi Falay, Dauly Ngbonda, Octavie Lunguya, Jan Jacobs, Gordon Dougan, Stijn Deborggraeve
Oct 28, 2019
Bloodstream infections by Salmonella enterica serovar Typhimurium constitute a major health burden in sub-Saharan Africa (SSA). These invasive non-typhoidal (iNTS) infections are dominated by isolates of the antibiotic...