Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures
Jacob D. Galson,
Sebastian Schaetzle,
Rachael J. M. Bashford-Rogers,
Matthew I. J. Raybould,
Aleksandr Kovaltsuk,
Gavin J. Kilpatrick,
Ralph Minter,
Donna K. Finch,
Jorge Dias,
Louisa K. James,
Gavin Thomas,
Wing-Yiu Jason Lee,
Jason Betley,
Olivia Cavlan,
Alex Leech,
Charlotte M. Deane,
Joan Seoane,
Carlos Caldas,
Daniel J. Pennington,
Paul Pfeffer,
Jane Osbourn
Dec 29, 2020
Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19 patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which is consistent across patients. Clonal expansion of the B...