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Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4.
Malvina Pizzuto, Caroline Lonez, Alberto Baroja-Mazo, Helios Martínez-Banaclocha, Panagiotis Tourlomousis, Monique Gangloff, Pablo Pelegrin, Jean-Marie Ruysschaert, Nicholas J Gay, Clare E Bryant
May 03, 2019
anti-inflammatory Barth syndrome cardiolipin Inflammation resolution TLR4-agonist TLR4-antagonist Toll-like receptor (TLR) Vaccine adjuvant Animals Anti-Infective Agents Binding Competitive Cardiolipins Cell Survival Chemokine CXCL10 HEK293 Cells Humans Lipopolysaccharide Receptors Lipopolysaccharides Lymphocyte Antigen 96 MACROPHAGES Mice Monocytes NF-kappa B NLR Family Pyrin Domain-Containing 3 Protein Protein Binding Signal Transduction Toll-Like Receptor 4 Tumor Necrosis Factor-alpha
Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4
Malvina Pizzuto, Caroline Lonez, Alberto Baroja-Mazo, Helios Martínez-Banaclocha, Panagiotis Tourlomousis, Monique Gangloff, Pablo Pelegrin, Jean-Marie Ruysschaert, Nicholas J. Gay, Clare E. Bryant
Jun 06, 2020
Abstract: Cardiolipins (CLs) are tetra-acylated diphosphatidylglycerols found in bacteria, yeast, plants, and animals. In healthy mammals, CLs are unsaturated, whereas saturated CLs are found in blood cells from Barth syndrome...