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Results: 4
Cover Image for VCP/p97 modulates PtdIns3P production and autophagy initiation. View Article
VCP/p97 modulates PtdIns3P production and autophagy initiation.
Lidia Wrobel, Sandra M Hill, Avraham Ashkenazi, David C Rubinsztein
Mar 01, 2021
ATXN3 PI(3)P PI3K VCP/p97 autophagy initiation Beclin 1 Autophagy Beclin-1 Phosphatidylinositol Phosphates
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Cover Image for Activation Mechanisms of the VPS34 Complexes. View Article
Activation Mechanisms of the VPS34 Complexes.
Yohei Ohashi
Nov 22, 2021
Phosphatidylinositol-3-phosphate (PtdIns(3)P) is essential for cell survival, and its intracellular synthesis is spatially and temporally regulated. It has major roles in two distinctive cellular pathways, namely, the autophagy...
ATG14L Beclin 1 PtdIns(3)P UVRAG VPS15 VPS34 Autophagy endocytic pathway Lipids Membranes Animals Class III Phosphatidylinositol 3-Kinases Enzyme Activation Humans Models Biological Multiprotein Complexes Phosphatidylinositol Phosphates Signal Transduction
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Cover Image for Polyglutamine tracts regulate autophagy View Article
Polyglutamine tracts regulate autophagy
DC Rubinsztein, A Ashkenazi, CF Bento, T Ricketts, M Vicinanza, F Siddiqi, M Pavel, F Squitieri, MC Haardenberg, S Imarisio, FM Menzies
Aug 08, 2017
Beclin 1 Huntington's disease Ataxin-3 Autophagy polyglutamine spinocerebellar ataxia Animals Ataxin-3 Autophagy Humans Models Biological Mutant Proteins Peptides Polymorphism Genetic Trinucleotide Repeat Expansion
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Cover Image for Genetic enhancement of macroautophagy in vertebrate models of neurodegenerative diseases. View Article
Genetic enhancement of macroautophagy in vertebrate models of neurodegenerative diseases.
Patrick Ejlerskov, Avraham Ashkenazi, David C Rubinsztein
Jun 29, 2018
Most of the neurodegenerative diseases that afflict humans manifest with the intraneuronal accumulation of toxic proteins that are aggregate-prone. Extensive data in cell and neuronal models support the concept that such...
ATG5 ATG7 Autophagy Beclin 1 Genetic Therapy Neurodegenerative disease Animals Autophagy Disease Models Animal Genetic Enhancement Humans Neurodegenerative Diseases
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