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Urban Endocrine Disruptors Targeting Breast Cancer Proteins.
Benzhydryl Compounds Binding Sites Breast Neoplasms Catalase Cytochrome P-450 CYP1A2 Databases Chemical Databases Protein Dioxins Endocrine Disruptors Environmental Pollutants Female Humans Molecular Dynamics Simulation Phenols Protein Binding Protein Structure Tertiary Recombinant Proteins Sex Hormone-Binding Globulin
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.
Elisa Vergari, Jakob G Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford JB Briant, Margarita V Chibalina, Fiona M Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils JG Rorsman, Ioannis I Spiliotis, Andrei Tarasov, Yanling Wu, Frances M Ashcroft, Patrik Rorsman
Feb 12, 2019
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by...
Animals Benzhydryl Compounds Blood Glucose Diabetes mellitus Female Glucagon Glucagon-Secreting Cells Glucosides Humans Hypoglycemia Insulin Male Mice Mice Inbred C57BL Mice Knockout Receptor Insulin Receptors Somatostatin Sodium-Glucose Transporter 2 Sodium-Glucose Transporter 2 Inhibitors Somatostatin
SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
Heeyoung Chae, Robert Augustin, Eva Gatineau, Eric Mayoux, Mohammed Bensellam, Nancy Antoine, Firas Khattab, Bao-Khanh Lai, Davide Brusa, Birgit Stierstorfer, Holger Klein, Bilal Singh, Lucie Ruiz, Michael Pieper, Michael Mark, Pedro L Herrera, Fiona M Gribble, Frank Reimann, Anne Wojtusciszyn, Christophe Broca, Nano Rita, Lorenzo Piemonti, Patrick Gilon
Nov 13, 2020
OBJECTIVE: Sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i), or gliflozins, are anti-diabetic drugs that lower glycemia by promoting glucosuria, but they also stimulate endogenous glucose and ketone body production....
Diabetes Gliflozins Glucagon Insulin SGLT2 inhibitor Animals Benzhydryl Compounds Blood Glucose Glucagon Glucagon-Like Peptide 1 Glucagon-Secreting Cells Glucose Glucosides Humans Insulin Insulin Secretion Insulin-Secreting Cells Islets of Langerhans Mice Pancreas Rats Sodium-Glucose Transporter 2 Sodium-Glucose Transporter 2 Inhibitors
muLTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19-Experimental drugs and mechanisms (TACTIC-E)
Ing Ni Lu, Spoorthy Kulkarni, Marie Fisk, Michalis Kostapanos, Edward Banham-Hall, Sonakshi Kadyan, Simon Bond, Sam Norton, Andrew Cope, James Galloway, Frances Hall, David Jayne, Ian B Wilkinson, Joseph Cheriyan
Oct 05, 2020
OBJECTIVES: To determine if a specific intervention reduces the composite of progression of patients with COVID-19-related disease to organ failure or death as measured by time to incidence of any one of the following: death...
Adaptive trial Ambrisentan covid-19 Dapagliflozin EDP1815 Experimental drugs Open-label Protocol randomised controlled trial Benzhydryl Compounds Betacoronavirus covid-19 Coronavirus Infections Glucosides Humans Immunologic Factors Intensive Care Units Pandemics Phenylpropionates Pneumonia Viral Pyridazines Randomized Controlled Trials as Topic Respiration Artificial SARS-CoV-2 Standard of Care COVID-19 Drug Treatment
Design and rationale of the EMPA-VISION trial
Moritz J Hundertmark, Olorunsola F Agbaje, Ruth Coleman, Jyothis T George, Rolf Grempler, Rury R Holman, Hanan Lamlum, Jisoo Lee, Joanne E Milton, Heiko G Niessen, Oliver Rider, Christopher T Rodgers, Ladislav Valkovič, Eleanor Wicks, Masliza Mahmod, Stefan Neubauer
May 05, 2021
Maternal serum concentrations of bisphenol A and propyl paraben in early pregnancy are associated with male infant genital development.
BG Fisher, A Thankamony, J Mendiola, CJ Petry, H Frederiksen, AM Andersson, A Juul, KK Ong, DB Dunger, IA Hughes, CL Acerini
Feb 26, 2020
Modafinil augmentation therapy in unipolar and bipolar depression
Alexander J Goss, Muzaffer Kaser, Sergi G Costafreda, Barbara J Sahakian, Cynthia HY Fu
Aug 21, 2017
OBJECTIVE: Current pharmacologic treatments for a depressive episode in unipolar major depressive disorder (MDD) and bipolar depression are limited by low rates of remission. Residual symptoms include a persistent low mood and...