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A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.
Amelie Griveau, Giorgio Seano, Samuel J Shelton, Robert Kupp, Arman Jahangiri, Kirsten Obernier, Shanmugarajan Krishnan, Olle R Lindberg, Tracy J Yuen, An-Chi Tien, Jennifer K Sabo, Nancy Wang, Ivy Chen, Jonas Kloepper, Louis Larrouquere, Mitrajit Ghosh, Itay Tirosh, Emmanuelle Huillard, Arturo Alvarez-Buylla, Michael C Oldham, Anders I Persson, William A Weiss, Tracy T Batchelor, Anat Stemmer-Rachamimov, Mario L Suvà, Joanna J Phillips, Manish K Aghi, Shwetal Mehta, Rakesh K Jain, David H Rowitch
Aug 16, 2018
Gliomas comprise heterogeneous malignant glial and stromal cells. While blood vessel co-option is a potential mechanism to escape anti-angiogenic therapy, the relevance of glial phenotype in this process is unclear. We show that...
Olig2 Wnt angiogenesis astrocyte Blood-Brain Barrier glioma invasiveness oligodendrocyte precursor p53 vessel co-option Animals Bevacizumab Blood-Brain Barrier Brain Neoplasms Cell Line Tumor Gene Expression Regulation Neoplastic glioma Humans Mice Neoplasm Transplantation Oligodendrocyte Transcription Factor 2 Oligodendroglia Temozolomide Tumor Cells Cultured Tumor Microenvironment Wnt Proteins Wnt Signaling Pathway
A Perspective on Cell Therapy and Cancer Vaccine in Biliary Tract Cancers (BTCs).
Shuting Han, Suat Ying Lee, Who-Whong Wang, Yu Bin Tan, Rachel Hui Zhen Sim, Rachael Cheong, Cherlyn Tan, Richard Hopkins, John Connolly, Wai Ho Shuen, Han Chong Toh
Nov 19, 2020
Biliary tract cancer (BTC) is a rare, but aggressive, disease that comprises of gallbladder carcinoma, intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, with heterogeneous molecular profiles. Advanced disease...
An update on long-acting therapies in chronic sight-threatening eye diseases of the posterior segment
Faruque Ghanchi, Rupert Bourne, Susan M Downes, Richard Gale, Christina Rennie, Ian Tapply, Sobha Sivaprasad
Jun 07, 2022
A randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in the treatment of patients with metastatic colorectal cancer-OBELICS (Optimization of BEvacizumab scheduLIng within Chemotherapy Scheme).
Antonio Avallone, Maria Carmela Piccirillo, Luigi Aloj, Guglielmo Nasti, Paolo Delrio, Francesco Izzo, Elena Di Gennaro, Fabiana Tatangelo, Vincenza Granata, Ernesta Cavalcanti, Piera Maiolino, Francesco Bianco, Pasquale Aprea, Mario De Bellis, Biagio Pecori, Gerardo Rosati, Chiara Carlomagno, Alessandro Bertolini, Ciro Gallo, Carmela Romano, Alessandra Leone, Corradina Caracò, Elisabetta de Lutio di Castelguidone, Gennaro Daniele, Orlando Catalano, Gerardo Botti, Antonella Petrillo, Giovanni M Romano, Vincenzo R Iaffaioli, Secondo Lastoria, Francesco Perrone, Alfredo Budillon
Dec 18, 2018
BACKGROUND: Despite the improvements in diagnosis and treatment, colorectal cancer (CRC) is the second cause of cancer deaths in both sexes. Therefore, research in this field remains of great interest. The approval of...
Critical role of bevacizumab scheduling in combination with pre-surgical chemo-radiotherapy in MRI-defined high-risk locally advanced rectal cancer
Antonio Avallone, Biagio Pecori, Franco Bianco, Luigi Aloj, Fabiana Tatangelo, Carmela Romano, Vincenza Granata, Pietro Marone, Alessandra Leone, Gerardo Botti, Antonella Petrillo, Corradina Caracò, Vincenzo R Iaffaioli, Paolo Muto, Giovanni Romano, Pasquale Comella, Alfredo Budillon, Paolo Delrio
Jul 01, 2019
adjuvant chemotherapy Bevacizumab locally advanced rectal cancer preoperative chemo-radiotherapy vessel normalization Adult Aged Angiogenesis Inhibitors Antineoplastic Combined Chemotherapy Protocols Bevacizumab Chemoradiotherapy Adjuvant Disease Progression Disease-Free Survival Drug Administration Schedule Early Termination of Clinical Trials Female Fluorouracil Humans Italy Kaplan-Meier Estimate Leucovorin Magnetic Resonance Imaging Male Middle Aged Neoadjuvant Therapy Neoplasm Recurrence Local Organoplatinum Compounds Oxaliplatin Predictive Value of Tests Quinazolines Rectal Neoplasms Risk Factors Thiophenes Time Factors Treatment Outcome
Disease-free and overall survival at 3.5 years for neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin and cyclophosphamide, for women with HER2 negative early breast cancer
HM Earl, L Hiller, J Dunn, C Blenkinsop, L Grybowicz, A-L Vallier, I Gounaris, J Abraham, L Hughes-Davies, K McAdam, S Chan, R Ahmad, T Hickish, D Rea, C Caldas, JMS Bartlett, DA Cameron, E Provenzano, J Thomas, RL Hayward, ARTemis Investigators Group
Jul 03, 2017
The use of error-category mapping in pharmacokinetic model analysis of dynamic contrast-enhanced MRI data.
Andrew B Gill, Gayathri Anandappa, Andrew J Patterson, Andrew N Priest, Martin J Graves, Tobias Janowitz, Duncan I Jodrell, Tim Eisen, David J Lomas
Feb 10, 2015
DCE-MRI error analysis metastatic renal cell carcinoma pharamacokinetic modeling REPEATABILITY Algorithms Antibodies Monoclonal Humanized Area Under Curve Bevacizumab Carcinoma Renal Cell Contrast Media Humans Image Processing Computer-Assisted Kidney Neoplasms Magnetic Resonance Imaging Models Theoretical Neoplasm Metastasis Reproducibility of Results Software
Neoadjuvant FOLFIRI+bevacizumab in patients with resectable liver metastases from colorectal cancer
G Nasti, MC Piccirillo, F Izzo, A Ottaiano, V Albino, P Delrio, C Romano, P Giordano, S Lastoria, C Caracò, E de Lutio di Castelguidone, R Palaia, G Daniele, L Aloj, G Romano, RV Iaffaioli
Dec 21, 2018
BACKGROUND: Preoperative treatment of resectable liver metastases from colorectal cancer (CRC) is a matter of debate. The aim of this study was to assess the feasibility and activity of bevacizumab plus FOLFIRI in this setting....
Adult Aged Antibodies Monoclonal Humanized Antineoplastic Combined Chemotherapy Protocols Bevacizumab camptothecin Chemotherapy Adjuvant Colorectal Neoplasms Disease-Free Survival Female Fluorouracil Humans Kaplan-Meier Estimate Leucovorin Liver Neoplasms Male Middle Aged Neoadjuvant Therapy Survival Rate
18F-FDG PET/CT Is an Early Predictor of Pathologic Tumor Response and Survival to Preoperative Radiochemotherapy with Bevacizumab in High Risk Locally Advanced Rectal Cancer.
Antonio Avallone, Luigi Aloj, Biagio Pecori, Corradina Caraco, Alfonso De Stefano, Fabiana Tatangelo, Lucrezia Silvestro, Vincenza Granata, Francesco Bianco, Carmela Romano, Francesca Di Gennaro, Alfredo Budillon, Antonella Petrillo, Paolo Muto, Gerardo Botti, Paolo Delrio, Secondo Lastoria
Oct 18, 2019
There is an unmet need for predictive biomarkers of the clinical benefit of anti-angiogenic drugs.The aim of the present study was to prospectively evaluate the value of FDG-PET/CT performed during and after preoperative...
WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma.
Nicholas Coupe, Lina Guo, Esther Bridges, Leticia Campo, Olivia Espinosa, Richard Colling, Andrea Marshall, Ashwin Nandakumar, Ruud van Stiphout, Francesca M Buffa, Pippa G Corrie, Mark R Middleton, Valentine M Macaulay
Mar 29, 2023