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Historically, the limited availability of primary endothelial cells from patients with vascular disorders has hindered the study of the molecular mechanisms underlying endothelial dysfunction in these individuals. However, the...

Adult Blood Cells Cell Culture Techniques Cellular Reprogramming Endothelial Cells Humans Induced Pluripotent Stem Cells

Mosquito blood cells are immune cells that help control infection by vector-borne pathogens. Despite their importance, little is known about mosquito blood cell biology beyond morphological and functional criteria used for their...

Blood Cells entomology insect immunity Malaria Single-cell sequencing Animals Animals Genetically Modified Anopheles Blood Cells Cell Communication Cell Plasticity Datasets as Topic Female Genomics Malaria Mosquito Vectors RNA Sequence Analysis RNA Single-Cell Analysis Transcriptome

Adult stem cells Bayes Theorem Blood Cells Cell Count Cell Division Cell Lineage Clone Cells DNA Mutational Analysis Embryonic Development Genome Human Granulocytes Hematopoiesis Hematopoietic Stem Cells Humans Lymphocytes Male Middle Aged Mutation Time Factors

Although cellular mechanical properties are known to alter during stem cell differentiation, understanding of the functional relevance of such alterations is incomplete. Here, we show that during the course of differentiation of...

Adaptation Physiological Biomechanical Phenomena Blood Cells Cell Differentiation Cell Line Cell Movement Hemodynamics Humans MACROPHAGES Microfluidics Monocytes Myeloid Cells Neutrophils Primary Cell Culture Viscosity

Blood Cells Child Databases Genetic Histiocytosis Langerhans-Cell Humans Mutation Proto-Oncogene Proteins B-raf

Autohemotherapy with ozonated blood is used in the treatment of a broad spectrum of clinical disorders. Ozone demonstrates strong oxidizing properties and causes damage to cell membranes. The impact of whole-blood ozonation on...

autohemotherapy Blood Coagulation Microparticles Ozone Blood Cells Blood Coagulation Cell-Derived Microparticles Endothelial Cells Humans Male Ozone

Blood is arguably the most important bodily fluid and its analysis provides crucial health status information. A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining...

P. falciparum biophysics cell mechanics human human biology Leukemia Malaria Medicine Neutrophil Activation real-time deformability cytometry spherocytosis structural biology Blood Cells Cytological Techniques Diagnostic Tests Routine Humans Single-Cell Analysis

Cytokines Genomics inflammasome Inflammation Humans Interleukin-1alpha Polymorphism Single Nucleotide Genome-Wide Association Study Interleukin-1beta Inflammation Blood Cells

Blood Cells Cellular Microenvironment Female Fetus Flow Cytometry Gene Expression Profiling Hematopoiesis Humans Liver Lymphoid Tissue Single-Cell Analysis Stem Cells

Somatic mutations drive the development of cancer and may contribute to ageing and other diseases1,2. Despite their importance, the difficulty of detecting mutations that are only present in single cells or small clones has...

Alzheimer Disease Blood Cells Cell Differentiation Cell Division Cohort Studies Colon DNA Mutational Analysis Epithelium Granulocytes Healthy Volunteers Humans Male Middle Aged Muscle Smooth Mutagenesis Mutation Mutation Rate Neurons single molecule imaging Stem Cells

The ontogeny of the human haematopoietic system during fetal development has previously been characterized mainly through careful microscopic observations1. Here we reconstruct a phylogenetic tree of blood development using...

Blood Cells Cell Lineage Clone Cells DNA Mutational Analysis Embryonic Development Fetus Germ Layers HEALTH Hematopoietic System Humans Karyotyping Male Mesoderm Mutation Mutation Rate Organ Specificity Time Factors whole genome sequencing Workflow

Acclimatization Adult Blood Cells Carnitine O-Palmitoyltransferase Diet Fatty Acids Female Humans Inuit Male Middle Aged Polymorphism Single Nucleotide selection Genetic

Animals Binding Sites Blood Cells Chromatin Immunoprecipitation DNA Hematopoiesis Mice Nucleotide Motifs Regulatory Elements Transcriptional Sequence Analysis DNA Transcription Factors Transcription Genetic

chromosome conformation Disease gene prioritization Gene regulation non-coding genetic variation promoter capture Hi-C Blood Cells Cell Lineage Cell Separation Chromatin Disease Enhancer Elements Genetic Epigenomics Genetic Predisposition to Disease Genome-Wide Association Study Hematopoiesis Humans Polymorphism Single Nucleotide Promoter Regions Genetic Quantitative Trait Loci

Somatic cells acquire mutations throughout the course of an individual's life. Mutations occurring early in embryogenesis are often present in a substantial proportion of, but not all, cells in postnatal humans and thus have...

Adult Blood Cells Cell Lineage Embryo Mammalian Embryonic Development Genome Human Germ-Line Mutation Humans Mosaicism Mutagenesis Mutation Mutation Rate

The production of extracellular vesicles (EV) is a ubiquitous feature of eukaryotic cells but pathological events can affect their formation and constituents. We sought to characterize the nature, profile and protein signature...

ALPHA-SYNUCLEIN Blood Cells Erythrocytes extracellular vesicles Aged Biomarkers Blood Cell Count Erythrocytes extracellular vesicles Female Humans Huntington Disease Male Middle Aged Parkinson Disease Proteomics

Alleles Amino Acid Sequence Base Sequence Blood Cells Child Child Preschool Cytokines Disease Susceptibility Female FIBROBLASTS Gene Expression Regulation Humans Interferon-alpha Interferon-gamma Janus Kinase 1 Male Mutation Mycobacterium Infections Pedigree Phosphorylation Protein Domains STAT Transcription Factors Signal Transduction TYK2 Kinase Young Adult

Animals Blood Cells Butadienes Cattle Cell Survival Coated Materials Biocompatible Elastomers Heart valve prosthesis Hematologic Tests Hemolysis Humans Materials Testing Pericardium Polyenes Polymers Polystyrenes Polytetrafluoroethylene

Animals Base Sequence Blood Cells Computer Simulation Diffusion Female Gastrulation Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Male Mice Inbred ICR Models Genetic Molecular Sequence Data Single-Cell Analysis Transcription Genetic