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Comparison of four methods to measure haemoglobin concentrations in whole blood donors (COMPARE)
Steven Bell, Michael Sweeting, Anna Ramond, Ryan Chung, Stephen Kaptoge, Matthew Walker, Thomas Bolton, Jennifer Sambrook, Carmel Moore, Amy McMahon, Sarah Fahle, Donna Cullen, Susan Mehenny, Angela M Wood, Jane Armitage, Willem H Ouwehand, Gail Miflin, David J Roberts, John Danesh, Emanuele Di Angelantonio, COMPARE Study Group
Jan 04, 2021
OBJECTIVE: To compare four haemoglobin measurement methods in whole blood donors. BACKGROUND: To safeguard donors, blood services measure haemoglobin concentration in advance of each donation. NHS Blood and Transplant's (NHSBT)...
HemoCue gravimetry haemoglobin screening inappropriate bleeding inappropriate deferral non-invasive haemoglobin measurement whole blood donor Adolescent Adult Aged Aged 80 and over Anemia Biomarkers Blood Donors Cross-Over Studies Donor Selection Female Hemoglobinometry Hemoglobins Humans Male Middle Aged Reference Standards Sensitivity and Specificity Spectrophotometry Young Adult
Human marginal zone B cell development from early T2 progenitors.
Thomas J Tull, Michael J Pitcher, William Guesdon, Jacqueline HY Siu, Cristina Lebrero-Fernández, Yuan Zhao, Nedyalko Petrov, Susanne Heck, Richard Ellis, Pawan Dhami, Ulrich D Kadolsky, Michelle Kleeman, Yogesh Kamra, David J Fear, Susan John, Wayel Jassem, Richard W Groves, Jeremy D Sanderson, Michael G Robson, David P D'Cruz, Mats Bemark, Jo Spencer
Mar 12, 2021
B cells emerge from the bone marrow as transitional (TS) B cells that differentiate through T1, T2, and T3 stages to become naive B cells. We have identified a bifurcation of human B cell maturation from the T1 stage forming...
Adult Aged Blood Donors Case-Control Studies Cell Differentiation Cell Lineage Cells Cultured Female Gastrointestinal Tract Humans Immunoglobulin M Integrin beta Chains Interleukin-4 Receptor alpha Subunit Lupus Nephritis Lymphoid Tissue Male Middle Aged Phenotype Precursor Cells B-Lymphoid Sequence Analysis RNA Single-Cell Analysis Transcriptome Young Adult
Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden.
X Castro Dopico, S Muschiol, M Christian, L Hanke, DJ Sheward, NF Grinberg, J Rorbach, G Bogdanovic, GM Mcinerney, T Allander, C Wallace, B Murrell, J Albert, GB Karlsson Hedestam
Oct 15, 2021
covid-19 SARS-CoV-2 Sweden antibody testing population immunity serology Seroprevalence Adult Antibodies Neutralizing Antibodies Viral Blood Donors covid-19 Cross-Sectional Studies Female Humans Immunoglobulin G Male Pandemics Pregnancy Pregnancy Complications Infectious Prospective Studies SARS-CoV-2 Seroepidemiologic Studies Spike Glycoprotein Coronavirus Sweden Young Adult
RLS and blood donation.
Brendan J Burchell, Richard P Allen, Jessica K Miller, Wayne A Hening, Christopher J Earley
Apr 15, 2012
BACKGROUND AND PURPOSE: The link between brain iron deficiency and RLS is now well established. In a related observation, several conditions that can deplete iron stores have been linked to increased probability of RLS. Blood...
The INTERVAL trial to determine whether intervals between blood donations can be safely and acceptably decreased to optimise blood supply
Carmel Moore, Jennifer Sambrook, Matthew Walker, Zoe Tolkien, Stephen Kaptoge, David Allen, Susan Mehenny, Jonathan Mant, Emanuele Di Angelantonio, Simon G Thompson, Willem Ouwehand, David J Roberts, John Danesh
Sep 18, 2014
2014 European Conference on Donor Health and Management.
Longer-term efficiency and safety of increasing the frequency of whole blood donation (INTERVAL)
Stephen Kaptoge, Emanuele Di Angelantonio, Carmel Moore, Matthew Walker, Jane Armitage, Willem H Ouwehand, David J Roberts, John Danesh, Simon G Thompson, INTERVAL Trial Group
Jun 13, 2019
Prevalence of SARS-CoV-2 antibodies in healthy blood donors from the state of Tyrol, Austria, in summer 2020.
Anita Siller, Gregor A Wachter, Sabrina Neururer, Bernhard Pfeifer, Manfred Astl, Wegene Borena, Janine Kimpel, Sebastian Elmer, Franziska Spöck, Anja Vales, Annelies Mühlbacher, Manfred Gaber, Peter Willeit, Harald Schennach
Jan 06, 2022
BACKGROUND: Seroepidemiological studies provide important insight into the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) in our society. We aimed to determine seropositivity of SARS-CoV‑2 antibodies and...
Seroprevalence of Anti-SARS-CoV-2 IgG Antibodies in Tyrol, Austria
Lisa Seekircher, Anita Siller, Manfred Astl, Lena Tschiderer, Gregor A Wachter, Bernhard Pfeifer, Andreas Huber, Manfred Gaber, Harald Schennach, Peter Willeit
Sep 02, 2022
Because a large proportion of the Austrian population has been infected with SARS-CoV-2 during high incidence periods in winter 2021/2022, up-to-date estimates of seroprevalence of anti-SARS-CoV-2 antibodies are required to...
Seroprevalence of Anti-SARS-CoV-2 IgG Antibodies in Tyrol, Austria
Lisa Seekircher, Anita Siller, Manfred Astl, Lena Tschiderer, Gregor A Wachter, Bernhard Pfeifer, Andreas Huber, Manfred Gaber, Harald Schennach, Peter Willeit
Oct 24, 2022
Because a large proportion of the Austrian population has been infected with SARS-CoV-2 during high incidence periods in winter 2021/2022, up-to-date estimates of seroprevalence of anti-SARS-CoV-2 antibodies are required to...
Impact of a post-donation hemoglobin testing strategy on efficiency and safety of whole blood donation in England
Lois G Kim, Thomas Bolton, Michael J Sweeting, Steven Bell, Sarah Fahle, Amy McMahon, Matthew Walker, Eamonn Ferguson, Gail Miflin, David J Roberts, Emanuele Di Angelantonio, Angela M Wood
Feb 17, 2023
BACKGROUND: Deferrals due to low hemoglobin are time-consuming and costly for blood donors and donation services. Furthermore, accepting donations from those with low hemoglobin could represent a significant safety issue. One...
Safety of blood donation by individuals over age 70 and their contribution to the blood supply in five developed countries
Mindy Goldman, Marc Germain, Yves Grégoire, Ralph R Vassallo, Hany Kamel, Marjorie Bravo, David O Irving, Emanuele Di Angelantonio, Whitney R Steele, Sheila F O'Brien, Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators
Jan 29, 2019
BACKGROUND: Some countries impose an upper age limit on whole blood and double RBC donation while others do not. We evaluated the safety of blood donation in older individuals (≥71 years), and their contribution to the blood...
Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020.
Craig P Thompson, Nicholas E Grayson, Robert S Paton, Jai S Bolton, José Lourenço, Bridget S Penman, Lian N Lee, Valerie Odon, Juthathip Mongkolsapaya, Senthil Chinnakannan, Wanwisa Dejnirattisai, Matthew Edmans, Alex Fyfe, Carol Imlach, Kreepa Kooblall, Nicholas Lim, Chang Liu, César López-Camacho, Carol McInally, Anna L McNaughton, Narayan Ramamurthy, Jeremy Ratcliff, Piyada Supasa, Oliver Sampson, Beibei Wang, Alexander J Mentzer, Marc Turner, Malcolm G Semple, Kenneth Baillie, ISARIC4C investigators, Heli Harvala, Gavin R Screaton, Nigel Temperton, Paul Klenerman, Lisa M Jarvis, Sunetra Gupta, Peter Simmonds
Jan 18, 2021
BackgroundThe progression and geographical distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United Kingdom (UK) and elsewhere is unknown because typically only symptomatic individuals...
Covid19 SARS-CoV-2 pandemic serology SURVEILLANCE Scotland Adult Antibodies Neutralizing Antibodies Viral Betacoronavirus Blood Donors covid-19 Cluster Analysis Coronavirus Infections Enzyme-Linked Immunosorbent Assay Female Geography Medical Humans Inhibitory Concentration 50 Male Models Immunological Neutralization Tests Pandemics Pneumonia Viral Population Surveillance prevalence SARS-CoV-2 Scotland Sensitivity and Specificity Seroepidemiologic Studies Urban Population
Biases incurred from nonrandom repeat testing of haemoglobin levels in blood donors
To help prevent anaemia, it is a requisite for blood donors to undergo a haemoglobin test to ensure levels are not too low before donation. It is therefore important to have an accurate testing device and strategy to ensure...
Blood donation diagnostic performance multiple measurements selective testing simulation study Bias Blood Chemical Analysis Blood Donors Hemoglobins Humans Point-of-Care Systems Reproducibility of Results
Published by: Biom J
Seroprevalence, Waning and Correlates of Anti-SARS-CoV-2 IgG Antibodies in Tyrol, Austria
Anita Siller, Lisa Seekircher, Gregor A Wachter, Manfred Astl, Lena Tschiderer, Bernhard Pfeifer, Manfred Gaber, Harald Schennach, Peter Willeit
Apr 25, 2022
There is uncertainty about the seroprevalence of anti-SARS-CoV-2 antibodies in the general population of Austria and about the waning of antibodies over time. We conducted a seroepidemiological study between June 2020 and...
Hepatitis B Virus Chronic Infection in Blood Donors from Asian and African High or Medium Prevalence Areas
Jean-Pierre Allain, Shirley Owusu-Ofori, Xianlin Ye, Cyrille Bisseye, Mira El Chaar, Chengyao Li
May 24, 2022
Immune control of various infectious diseases, particularly viral, was shown to be more efficient for females than males. Response to viral vaccines (HAV, HBV) was higher in females. Data on hepatitis B virus (HBV) markers...
Development and validation of a universal blood donor genotyping platform
Nicholas S Gleadall, Barbera Veldhuisen, Jeremy Gollub, Adam S Butterworth, John Ord, Christopher J Penkett, Tiffany C Timmer, Carolin M Sauer, Nieke van der Bolt, Colin Brown, Kim Brugger, Alexander T Dilthey, Daniel Duarte, Shane Grimsley, Katja van den Hurk, John M Jongerius, Jessie Luken, Karyn Megy, Gail Miflin, Christopher S Nelson, Femmeke J Prinsze, Jennifer Sambrook, Ilenia Simeoni, Michael Sweeting, Nicole Thornton, Sara Trompeter, Salih Tuna, Ram Varma, Matthew R Walker, NIHR BioResource, John Danesh, David J Roberts, Willem H Ouwehand, Kathleen E Stirrups, Augusto Rendon, Connie M Westhoff, Emanuele Di Angelantonio, C Ellen van der Schoot, William J Astle, Nicholas A Watkins, William J Lane
Jun 17, 2020
Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
Kathrin Pieper, Joshua Tan, Luca Piccoli, Mathilde Foglierini, Sonia Barbieri, Yiwei Chen, Chiara Silacci-Fregni, Tobias Wolf, David Jarrossay, Marica Anderle, Abdirahman Abdi, Francis M Ndungu, Ogobara K Doumbo, Boubacar Traore, Tuan M Tran, Said Jongo, Isabelle Zenklusen, Peter D Crompton, Claudia Daubenberger, Peter C Bull, Federica Sallusto, Antonio Lanzavecchia
Dec 13, 2017
In two previously described donors, the extracellular domain of LAIR1, a collagen-binding inhibitory receptor encoded on chromosome 19 (ref. 1), was inserted between the V and DJ segments of an antibody. This insertion...
Antibodies Protozoan Antigens Protozoan B-Lymphocytes Blood Donors Erythrocytes Europe Female Genes Immunoglobulin Heavy Chain Humans Immunoglobulin Heavy Chains Immunoglobulin Switch Region Immunologic Memory Introns Malaria Male Mutagenesis Insertional Plasmodium falciparum Protein Domains Receptors Immunologic Templates Genetic VDJ Exons
Seroprevalence, Waning and Correlates of Anti-SARS-CoV-2 IgG Antibodies in Tyrol, Austria
There is uncertainty about the seroprevalence of anti-SARS-CoV-2 antibodies in the general population of Austria and about the waning of antibodies over time. We conducted a seroepidemiological study between June 2020...
Anita Siller, Lisa Seekircher, Gregor A Wachter, Manfred Astl, Lena Tschiderer, Bernhard Pfeifer, Manfred Gaber, Harald Schennach, Peter Willeit
Mar 11, 2022
Hepatitis B Virus Chronic Infection in Blood Donors from Asian and African High or Medium Prevalence Areas
Jean-Pierre Allain, Shirley Owusu-Ofori, Xianlin Ye, Cyrille Bisseye, Mira El Chaar, Chengyao Li
Mar 28, 2022
Immune control of various infectious diseases, particularly viral, was shown to be more efficient for females than males. Response to viral vaccines (HAV, HBV) was higher in females. Data on hepatitis B virus (HBV) markers...
Variations in hemoglobin measurement and eligibility criteria across blood donation services are associated with differing low-hemoglobin deferral rates
Saurabh Zalpuri, Bas Romeijn, Elias Allara, Mindy Goldman, Hany Kamel, Jed Gorlin, Ralph Vassallo, Yves Grégoire, Naoko Goto, Peter Flanagan, Joanna Speedy, Andreas Buser, Jose Mauro Kutner, Karin Magnussen, Johanna Castrén, Liz Culler, Harry Sussmann, Femmeke J Prinsze, Kevin Belanger, Veerle Compernolle, Pierre Tiberghien, Jose Manuel Cardenas, Manish J Gandhi, Kamille A West, Cheuk-Kwong Lee, Sian James, Deanne Wells, Laurie J Sutor, Silvano Wendel, Matthew Coleman, Axel Seltsam, Kimberly Roden, Whitney R Steele, Milos Bohonek, Ramir Alcantara, Emanuele Di Angelantonio, Katja van den Hurk, BEST Collaborative Study Group
Jan 10, 2020
BACKGROUND: Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent...
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