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Adiposity in Children Born Small for Gestational Age Is Associated With β-Cell Function, Genetic Variants for Insulin Resistance, and Response to Growth Hormone Treatment.
Ajay Thankamony, Rikke Beck Jensen, Susan M O'Connell, Felix Day, Jeremy Kirk, Malcolm Donaldson, Sten A Ivarsson, Olle Söder, Edna Roche, Hilary Hoey, Ken K Ong, David B Dunger, Anders Juul
Nov 20, 2015
Absorptiometry Photon Adiposity Body composition Body Height Child Child Preschool Female genetic variation Genotype Glucose Human Growth Hormone Humans Infant Newborn Infant Small for Gestational Age Insulin Insulin Resistance Insulin-Like Growth Factor I Insulin-Secreting Cells Male Pancreatic Function Tests Recombinant Proteins Treatment Outcome
Using Super-Imposition by Translation And Rotation (SITAR) to relate pubertal growth to bone health in later life
SITAR Ageing bone Density height Puberty weight Absorptiometry Photon Adolescent Adult Age Distribution Body Height Bone Density Child Child Preschool Female Growth Charts Humans Longitudinal Studies Male Middle Aged Models Biological Osteoporosis Puberty Regression Analysis Surveys and Questionnaires United Kingdom Weight Gain Young Adult
Testing the role of predicted gene knockouts in human anthropometric trait variation.
Samuel Lessard, Alisa K Manning, Cécile Low-Kam, Paul L Auer, Ayush Giri, Mariaelisa Graff, Claudia Schurmann, Hanieh Yaghootkar, Jian'an Luan, Tonu Esko, Tugce Karaderi, NHLBI GO Exome Sequence Project, GOT2D, T2D-GENES, GIANT Consortium, Erwin P Bottinger, Yingchang Lu, Chris Carlson, Mark Caulfield, Marie-Pierre Dubé, Rebecca D Jackson, Charles Kooperberg, Barbara McKnight, Ian Mongrain, Ulrike Peters, Alex P Reiner, David Rhainds, Nona Sotoodehnia, Joel N Hirschhorn, Robert A Scott, Patricia B Munroe, Timothy M Frayling, Ruth JF Loos, Kari E North, Todd L Edwards, Jean-Claude Tardif, Cecilia M Lindgren, Guillaume Lettre
Mar 14, 2016
Tall height and obesity are associated with an increased risk of aggressive prostate cancer
Aurora Perez-Cornago, Paul N Appleby, Tobias Pischon, Konstantinos K Tsilidis, Anne Tjønneland, Anja Olsen, Kim Overvad, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Annika Steffen, Antonia Trichopoulou, Pagona Lagiou, Maria Kritikou, Vittorio Krogh, Domenico Palli, Carlotta Sacerdote, Rosario Tumino, H Bas Bueno-De-Mesquita, Antonio Agudo, Nerea Larrañaga, Elena Molina-Portillo, Aurelio Barricarte, Maria-Dolores Chirlaque, J Ramón Quirós, Pär Stattin, Christel Häggström, Nick Wareham, Kay-Tee Khaw, Julie A Schmidt, Marc Gunter, Heinz Freisling, Dagfinn Aune, Heather Ward, Elio Riboli, Timothy J Key, Ruth C Travis
Jul 13, 2017
BACKGROUND: The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not differentiated between high-grade or advanced stage tumours...
Adiposity cohort study height High grade obesity prostate cancer Tumour characteristics Aged Body Height Body Mass Index Cohort Studies Humans Male Middle Aged Nutrition Assessment obesity Proportional Hazards Models Prospective Studies Prostatic Neoplasms Risk Factors Waist Circumference White People
Relationships of maternal and paternal anthropometry with neonatal body size, proportions and adiposity in an Australian cohort.
The many weak instruments problem and Mendelian randomization.
Neil M Davies, Stephanie von Hinke Kessler Scholder, Helmut Farbmacher, Stephen Burgess, Frank Windmeijer, George Davey Smith
Oct 22, 2014
ALSPAC Mendelian randomization allele scores continuously updating estimator height many weak instruments Adolescent Alleles Bias Body Height Causality Cohort Studies Computer Simulation England Female genetic variation Humans Least-Squares Analysis Likelihood Functions Linear Models Male Mendelian Randomization Analysis Random Allocation Risk Factors Vital Capacity
Timing of the Infancy-Childhood Growth Transition in Rural Gambia.
Robin M Bernstein, G Kesler O'Connor, Eric A Vance, Nabeel Affara, Saikou Drammeh, David B Dunger, Abdoulie Faal, Ken K Ong, Fatou Sosseh, Andrew M Prentice, Sophie E Moore
May 26, 2020
The Karlberg model of human growth describes the infancy, childhood, and puberty (ICP) stages as continuous and overlapping, and defined by transitions driven by sequential additional effects of several endocrine factors that...
Genetic markers of insulin sensitivity and insulin secretion are associated with spontaneous postnatal growth and response to growth hormone treatment in short SGA children
Rikke Beck Jensen, Ajay Thankamony, Felix Day, Robert A Scott, Claudia Langenberg, Jeremy Kirk, Malcolm Donaldson, Sten-A Ivarsson, Olle Söder, Edna Roche, Hilary Hoey, Anders Juul, Ken K Ong, David B Dunger
Aug 07, 2015
Neighbourhoods for Active Kids
Melody Oliver, Julia McPhee, Penelope Carroll, Erika Ikeda, Suzanne Mavoa, Lisa Mackay, Robin A Kearns, Marketta Kyttä, Lanuola Asiasiga, Nicholas Garrett, Judy Lin, Roger Mackett, Caryn Zinn, Helen Moewaka Barnes, Victoria Egli, Kate Prendergast, Karen Witten
Dec 18, 2019
INTRODUCTION: New Zealand children's physical activity, including independent mobility and active travel, has declined markedly over recent decades. The Neighbourhoods for Active Kids (NfAK) study examines how neighbourhood...
Accelerometry Built environment Child-centred methods obesity Participatory GIS Accelerometry Body Height Body Size Body Weight Child Cities Cross-Sectional Studies Diet Exercise Family Female Geographic Information Systems Health Behavior Humans Male Multilevel Analysis New Zealand Residence Characteristics Schools Social Environment Socioeconomic Factors Travel Waist Circumference Walking
Regional variation in weight-for-height z-scores and surface area/body mass ratio of Chilean children from birth to 3 years of age.
OBJECTIVE: The objectives of the study were to see how much of the variation in weight-for-height z-scores (WHZ) and surface area/body mass ratio (SA/mass) were associated with regional (county) differences including mean...
Ancient origins of low lean mass among South Asians and implications for modern type 2 diabetes susceptibility.
Adult height is associated with increased risk of ovarian cancer
Suzanne C Dixon-Suen, Christina M Nagle, Aaron P Thrift, Paul DP Pharoah, Ailith Ewing, Celeste Leigh Pearce, Wei Zheng, Australian Ovarian Cancer Study Group, Georgia Chenevix-Trench, Peter A Fasching, Matthias W Beckmann, Diether Lambrechts, Ignace Vergote, Sandrina Lambrechts, Els Van Nieuwenhuysen, Mary Anne Rossing, Jennifer A Doherty, Kristine G Wicklund, Jenny Chang-Claude, Audrey Y Jung, Kirsten B Moysich, Kunle Odunsi, Marc T Goodman, Lynne R Wilkens, Pamela J Thompson, Yurii B Shvetsov, Thilo Dörk, Tjoung-Won Park-Simon, Peter Hillemanns, Natalia Bogdanova, Ralf Butzow, Heli Nevanlinna, Liisa M Pelttari, Arto Leminen, Francesmary Modugno, Roberta B Ness, Robert P Edwards, Joseph L Kelley, Florian Heitz, Andreas du Bois, Philipp Harter, Ira Schwaab, Beth Y Karlan, Jenny Lester, Sandra Orsulic, Bobbie J Rimel, Susanne K Kjaer, Estrid Høgdall, Allan Jensen, Ellen L Goode, Brooke L Fridley, Julie M Cunningham, Stacey J Winham, Graham G Giles, Fiona Bruinsma, Roger L Milne, Melissa C Southey, Michelle AT Hildebrandt, Xifeng Wu, Karen H Lu, Dong Liang, Douglas A Levine, Maria Bisogna, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Elisa V Bandera, Sara H Olson, Helga B Salvesen, Liv Cecilie Vestrheim Thomsen, Reidun K Kopperud, Line Bjorge, Lambertus A Kiemeney, Leon FAG Massuger, Tanja Pejovic, Amanda Bruegl, Linda S Cook, Nhu D Le, Kenneth D Swenerton, Angela Brooks-Wilson, Linda E Kelemen, Jan Lubiński, Tomasz Huzarski, Jacek Gronwald, Janusz Menkiszak, Nicolas Wentzensen, Louise Brinton, Hannah Yang, Jolanta Lissowska, Claus K Høgdall, Lene Lundvall, Honglin Song, Jonathan P Tyrer, Ian Campbell, Diana Eccles, James Paul, Rosalind Glasspool, Nadeem Siddiqui, Alice S Whittemore, Weiva Sieh, Valerie McGuire, Joseph H Rothstein, Steven A Narod, Catherine Phelan, Harvey A Risch, John R McLaughlin, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A Gayther, Susan J Ramus, Aleksandra Gentry-Maharaj, Anna H Wu, Malcolm C Pike, Chiu-Chen Tseng, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Agnieszka Budzilowska, Iwona K Rzepecka, Penelope M Webb, Ovarian Cancer Association Consortium
May 23, 2018
BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence...
Maternal traditional dietary pattern and antiretroviral treatment exposure are associated with neonatal size and adiposity in urban, black South Africans
© 2018 The Authors. This study examines the associations between maternal Traditional dietary pattern adherence and HIV/treatment with neonatal size and adiposity in urban, black South Africans, as well as how specific maternal...
ADP air displacement plethysmography ART antiretroviral treatment DXA dual-energy X-ray absorptiometry FMI fat mass index GWG gestational weight gain QFFQ quantitative FFQ WLR weight:length ratio antiretroviral treatment Neonatal adiposity Pregnancy South Africa Traditional dietary patterns Adiposity Adult Anti-Retroviral Agents Birth Weight Black People Body composition Body Height culture Diet Female HIV Infections Humans Infant Newborn Male Maternal Nutritional Physiological Phenomena Mothers obesity Preconception Care Pregnancy Pregnancy Complications Infectious Prenatal Care South Africa Urban Population Weight Gain
Relative effects of postnatal rapid growth and maternal factors on early childhood growth trajectories.
Miaobing Zheng, Steven J Bowe, Kylie D Hesketh, Kristy Bolton, Rachel Laws, Peter Kremer, Ken K Ong, Sandrine Lioret, Elizabeth Denney-Wilson, Karen J Campbell
Feb 22, 2019
BACKGROUND: A range of postnatal and maternal factors influences childhood obesity, but their relative importance remains unclear. This study aimed to assess the relative impact of postnatal rapid growth and maternal factors on...
InFANT program DETERMINANTS growth Infant Maternal Trajectory Australia Body Height Body Mass Index Child Nutritional Physiological Phenomena Child Preschool Female Humans Infant Infant Nutritional Physiological Phenomena Infant Newborn Longitudinal Studies Male Nutrition Surveys Nutritional Status Pediatric Obesity Waist Circumference
Update on the predictability of tall stature from DNA markers in Europeans.
Fan Liu, Kaiyin Zhong, Xiaoxi Jing, André G Uitterlinden, A Emile J Hendriks, Stenvert LS Drop, Manfred Kayser
Jun 24, 2019
Predicting adult height from DNA has important implications in forensic DNA phenotyping. In 2014, we introduced a prediction model consisting of 180 height-associated SNPs based on data from 10,361 Northwestern Europeans...
Height, body mass index and prostate cancer risk and mortality by way of detection and cancer risk category.
Sylvia HJ Jochems, Pär Stattin, Christel Häggström, Bengt Järvholm, Marju Orho-Melander, Angela M Wood, Tanja Stocks
Oct 07, 2020
Obesity is a risk factor for advanced, but not localised, prostate cancer (PCa), and for poor prognosis. However, the detection of localised PCa through asymptomatic screening might influence these associations. We investigated...
Increases in bioactive IGF do not parallel increases in total IGF-I during growth hormone treatment of children born SGA.
Mathilde Gersel Wegmann, Rikke Beck Jensen, Ajay Thankamony, Jan Frystyk, Edna Roche, Hilary Hoey, Jeremy Kirk, Guftar Shaikh, Sten-A Ivarsson, Olle Söder, David B Dunger, Anders Juul
Nov 19, 2019
BACKGROUND: Some children born small for gestational age (SGA) experience supra-physiological insulin-like growth factor-I (IGF-I) concentrations during GH treatment. However, measurements of total IGF-I concentrations may not...
Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer
Nikhil K Khankari, Xiao-Ou Shu, Wanqing Wen, Peter Kraft, Sara Lindström, Ulrike Peters, Joellen Schildkraut, Fredrick Schumacher, Paolo Bofetta, Angela Risch, Heike Bickeböller, Christopher I Amos, Douglas Easton, Rosalind A Eeles, Stephen B Gruber, Christopher A Haiman, David J Hunter, Stephen J Chanock, Brandon L Pierce, Wei Zheng, Colorectal Transdisciplinary Study (CORECT), Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) Discovery, Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE), Transdisciplinary Research in Cancer of the Lung (TRICL)
Oct 31, 2016
Brain charts for the human lifespan
RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Bin Bae, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, S Desrivieres, G Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, I Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, R Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, R Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, K Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, DP Linares, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, BTT Yeo, HJ Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, AF Alexander-Bloch, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, ASRB, CALM team, Cam-CAN, 3R-BRAIN CCNP, COBRE, ENIGMA Developmental Brain Age Working Group, FinnBrain, Harvard Aging Brain Study, KNE96 IMAGEN, NSPN, OASIS-3, OpenPain Project, POND, VETSA, Bullmore, E.T The PREVENT-AD Research Group
May 09, 2022
Mendelian randomization with invalid instruments
MR-Egger test Mendelian randomization invalid instruments Meta-Analysis pleiotropy small study bias Bias blood pressure Body Height Causality Coronary Artery Disease Genetic Pleiotropy genetic variation Humans Mendelian Randomization Analysis Meta-Analysis as Topic Models Biological Regression Analysis Respiration Risk Assessment Statistics as Topic
IGF-1 and cardiometabolic diseases
AIMS/HYPOTHESIS: Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular disease. However, the causal role of IGF-1 levels within the normal range in cardiometabolic disease...
Association of preeclampsia with anthropometric measures and blood pressure in Indian children.
Karuna Randhir, Hemlata Pisal, Vrushali Kadam, Amrita Khaire-Ghadge, Nandini Malshe, Ruma Deshpande, Sonali Palkar, Sanjay Lalwani, Kalyanaraman Kumaran, Chittaranjan Yajnik, Clive Osmond, Caroline Fall, Sadhana Joshi
May 05, 2020
BACKGROUND AND OBJECTIVE: Birth weight and post-natal growth are important predictors of adult health. Preeclampsia (PE) is associated with low birth weight and may have long term effects on the health of the children. The...
A Polygenic Risk Score to Predict Future Adult Short Stature Among Children.
Tianyuan Lu, Vincenzo Forgetta, Haoyu Wu, John RB Perry, Ken K Ong, Celia MT Greenwood, Nicholas J Timpson, Despoina Manousaki, J Brent Richards
Apr 26, 2021
CONTEXT: Adult height is highly heritable, yet no genetic predictor has demonstrated clinical utility compared to mid-parental height. OBJECTIVE: To develop a polygenic risk score for adult height and evaluate its clinical...
ALSPAC UK Biobank adult height prediction parental height polygenic risk score short stature Adult Aged Area Under Curve Body Height Child Child Preschool Female Genome-Wide Association Study Growth Disorders Humans Longitudinal Studies Male Middle Aged Predictive Value of Tests ROC Curve Risk Assessment Risk Factors United Kingdom White People
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