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Results: 4
Morphological and genomic shifts in mole-rat 'queens' increase fecundity but reduce skeletal integrity.
Rachel A Johnston, Philippe Vullioud, Jack Thorley, Henry Kirveslahti, Leyao Shen, Sayan Mukherjee, Courtney M Karner, Tim Clutton-Brock, Jenny Tung
Jul 09, 2021
In some mammals and many social insects, highly cooperative societies are characterized by reproductive division of labor, in which breeders and nonbreeders become behaviorally and morphologically distinct. While differences in...
Chromosomes cooperative breeding eusociality evolutionary biology Gene Expression Gene regulation mole-rat phenotypic plasticity skeletal bone Age Factors Animals Biological Evolution Bone Development Cooperative Behavior Femur Fertility Gene Expression Regulation Genome Lumbar Vertebrae Mole Rats Sex Factors Sexual Behavior Animal Social Behavior
Pancreas deficiency modifies bone development in the ovine fetus near term.
Stuart A Lanham, Dominique Blache, Richard OC Oreffo, Abigail L Fowden, Alison J Forhead
Jan 06, 2022
Hormones have an important role in the regulation of fetal growth and development, especially in response to nutrient availability in utero. Using micro-CT and an electromagnetic three-point bend test, this study examined the...
NMR spectroscopy of native and in vitro tissues implicates polyADP ribose in biomineralization.
W Ying Chow, Rakesh Rajan, Karin H Muller, David G Reid, Jeremy N Skepper, Wai Ching Wong, Roger A Brooks, Maggie Green, Dominique Bihan, Richard W Farndale, David A Slatter, Catherine M Shanahan, Melinda J Duer
Sep 11, 2018
Nuclear magnetic resonance (NMR) spectroscopy is useful to determine molecular structure in tissues grown in vitro only if their fidelity, relative to native tissue, can be established. Here, we use multidimensional NMR spectra...
Sex- and bone-specific responses in bone structure to exogenous leptin and leptin receptor antagonism in the ovine fetus.
Miles J De Blasio, Stuart A Lanham, Dominique Blache, Richard OC Oreffo, Abigail L Fowden, Alison J Forhead
Apr 27, 2018
Widespread expression of leptin and its receptor in developing cartilage and bone suggests that leptin may regulate bone growth and development in the fetus. Using microcomputed tomography, this study investigated the effects of...