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Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS)
Philip M Bath, Lisa J Woodhouse, Jason P Appleton, Maia Beridze, Hanne Christensen, Robert A Dineen, Lelia Duley, Timothy J England, Katie Flaherty, Diane Havard, Stan Heptinstall, Marilyn James, Kailash Krishnan, Hugh S Markus, Alan A Montgomery, Stuart J Pocock, Marc Randall, Annemarei Ranta, Thompson G Robinson, Polly Scutt, Graham S Venables, Nikola Sprigg, TARDIS Investigators
Mar 07, 2018
BACKGROUND: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy...
Acute Disease Aged Aspirin Brain Ischemia Clopidogrel Denmark Dipyridamole Drug Therapy Combination Female Georgia Hemorrhage Humans Ischemia Ischemic Attack Transient Male Middle Aged New Zealand Platelet Aggregation Inhibitors Prospective Studies Recurrence Research Design Risk Assessment stroke Thrombolytic Therapy Ticlopidine Treatment Outcome United Kingdom
Clinical frailty independently predicts early mortality after ischaemic stroke.
Nicholas R Evans, Jasmine Wall, Benjaman To, Stephen J Wallis, Roman Romero-Ortuno, Elizabeth A Warburton
Dec 16, 2019
Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes
George Hindy, Gunnar Engström, Susanna C Larsson, Matthew Traylor, Hugh S Markus, Olle Melander, Marju Orho-Melander, Stroke Genetics Network (SiGN)
Jun 21, 2018
BACKGROUND AND PURPOSE: Statin therapy is associated with a lower risk of ischemic stroke supporting a causal role of low-density lipoprotein (LDL) cholesterol. However, more evidence is needed to answer the question whether LDL...
Cholesterol HDL Cholesterol LDL Polymorphism Single Nucleotide stroke Triglycerides Brain Ischemia Causality cerebral small vessel diseases Cholesterol HDL Cholesterol LDL Humans Intracranial Arteriosclerosis Intracranial Embolism Mendelian Randomization Analysis Multivariate Analysis Polymorphism Single Nucleotide stroke Triglycerides
Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury.
Tonny V Veenith, Eleanor L Carter, Thomas Geeraerts, Julia Grossac, Virginia FJ Newcombe, Joanne Outtrim, Gloria S Gee, Victoria Lupson, Rob Smith, Franklin I Aigbirhio, Tim D Fryer, Young T Hong, David K Menon, Jonathan P Coles
Mar 30, 2016
The Recognition-Response Gap in Acute Stroke
Lea O Wilhelm, Paul Gellert, Martin White, Vera Araujo-Soares, Gary A Ford, Joan E Mackintosh, Helen Rodgers, Falko F Sniehotta, Richard G Thomson, Stephan U Dombrowski
Oct 28, 2019
stroke Behavior delay prehospital delay Public Health Adolescent Adult Aged Aged 80 and over Brain Ischemia Emergency Medical Services England Female Health Knowledge Attitudes practice Humans Male Middle Aged RECOGNITION psychology Reperfusion Risk Factors Self Efficacy stroke Surveys and Questionnaires Telephone Time Factors Time-to-Treatment Young Adult
The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke
Tammy YN Tong, Paul N Appleby, Timothy J Key, Christina C Dahm, Kim Overvad, Anja Olsen, Anne Tjønneland, Verena Katzke, Tilman Kühn, Heiner Boeing, Anna Karakatsani, Eleni Peppa, Antonia Trichopoulou, Elisabete Weiderpass, Giovanna Masala, Sara Grioni, Salvatore Panico, Rosario Tumino, Jolanda MA Boer, WM Monique Verschuren, J Ramón Quirós, Antonio Agudo, Miguel Rodríguez-Barranco, Liher Imaz, María-Dolores Chirlaque, Conchi Moreno-Iribas, Gunnar Engström, Emily Sonestedt, Marcus Lind, Julia Otten, Kay-Tee Khaw, Dagfinn Aune, Elio Riboli, Nicholas J Wareham, Fumiaki Imamura, Nita G Forouhi, Emanuele Di Angelantonio, Angela M Wood, Adam S Butterworth, Aurora Perez-Cornago
Jan 13, 2020
Predicting 10-year stroke mortality
Weronika A Szlachetka, Tiberiu A Pana, Mamas A Mamas, Joao H Bettencourt-Silva, Anthony K Metcalf, John F Potter, David J McLernon, Phyo K Myint
Jun 07, 2022
Predicting long-term stroke mortality is a clinically important and unmet need. We aimed to develop and internally validate a 10-year ischaemic stroke mortality prediction score. In this UK cohort study, 10,366 patients with...
Cerebrovascular disease Ischaemic stroke long-term mortality Prediction score Prognosis Aged Aged 80 and over Atrial fibrillation Brain Ischemia Cohort Studies Coronary Disease Female Heart Failure Humans Hypertension ischemic stroke Male Nomograms peripheral vascular diseases Pulmonary Disease Chronic Obstructive Risk Factors stroke
Loes CA Rutten-Jacobs, Matthew Traylor, Poneh Adib-Samii, Vincent Thijs, Cathie Sudlow, Peter M Rothwell, Giorgio Boncoraglio, Martin Dichgans, James Meschia, Jane Maguire, Christopher Levi, Natalia S Rost, Jonathan Rosand, Ahamad Hassan, Steve Bevan, Hugh S Markus
Jan 08, 2016
Serum magnesium and calcium levels in relation to ischemic stroke
Susanna C Larsson, Matthew Traylor, Stephen Burgess, Giorgio B Boncoraglio, Christina Jern, Karl Michaëlsson, Hugh S Markus, MEGASTROKE Project of the International Stroke Genetics Consortium
Mar 20, 2019
OBJECTIVE: To determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach. METHODS: Analyses were conducted using...
Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke.
Raquel Rodríguez-González, Tomás Sobrino, Manuel Rodríguez-Yáñez, Mónica Millán, David Brea, Elena Miranda, Octavio Moldes, Juan Pérez, David A Lomas, Rogelio Leira, Antoni Dávalos, José Castillo
Jun 13, 2011
BACKGROUND: Neuroserpin has shown neuroprotective effects in animal models of cerebral ischemia and has been associated with functional outcome after ischemic stroke. Our aim was to study whether neuroserpin serum levels could...
Matthew Traylor, Loes CA Rutten-Jacobs, Elizabeth G Holliday, Rainer Malik, Cathie Sudlow, Peter M Rothwell, Jane M Maguire, Simon A Koblar, Steve Bevan, Giorgio Boncoraglio, Martin Dichgans, Chris Levi, Cathryn M Lewis, Hugh S Markus
Sep 08, 2015
Evaluation of the sensitivity of R1ρ MRI to pH and macromolecular density.
Syed O Ali, Petros Fessas, Joshua D Kaggie, Fulvio Zaccagna, Gavin Houston, Scott Reid, Martin J Graves, Ferdia A Gallagher
Feb 21, 2019
The tumor microenvironment is characteristically acidic and this extracellular acidosis is known to play a role in carcinogenesis and metastasis and can affect tumor chemosensitivity and radiosensitivity. Intracellular pH has...
MRI R(1)ρ T(1)ρ Tumor Microenvironment pH basal ganglia Brain Brain Ischemia Brain Mapping Contrast Media Gadolinium Gray Matter Healthy Volunteers Humans Hydrogen-Ion Concentration Macromolecular Substances Magnetic Resonance Imaging Male Neoplasm Metastasis Neoplasms Phantoms imaging Reproducibility of Results Sensitivity and Specificity stroke Tumor Microenvironment Young Adult
Leveraging Genetic Data to Elucidate the Relationship Between COVID-19 and Ischemic Stroke.
Verena Zuber, Alan Cameron, Evangelos P Myserlis, Leonardo Bottolo, Israel Fernandez-Cadenas, Stephen Burgess, Christopher D Anderson, Jesse Dawson, Dipender Gill
Sep 30, 2021
Background The relationship between COVID-19 and ischemic stroke is poorly understood due to potential unmeasured confounding and reverse causation. We aimed to leverage genetic data to triangulate reported associations. Methods...
COVID‐19 Mendelian randomization cross‐trait linkage disequilibrium score regression ischemic stroke Body Mass Index Brain Ischemia C-Reactive Protein covid-19 Genome-Wide Association Study Humans Inflammation ischemic stroke Mendelian Randomization Analysis Polymorphism Single Nucleotide Risk Factors Smoking
Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke.
Amin Mottahedin, Hiran A Prag, Andreas Dannhorn, Richard Mair, Christina Schmidt, Ming Yang, Annabel Sorby-Adams, Jordan J Lee, Nils Burger, Duvaraka Kulaveerasingam, Margaret M Huang, Stefano Pluchino, Luca Peruzzotti-Jametti, Richard Goodwin, Christian Frezza, Michael P Murphy, Thomas Krieg
Feb 12, 2023
Genetic predisposition to smoking in relation to 14 cardiovascular diseases.
Susanna C Larsson, Amy M Mason, Magnus Bäck, Derek Klarin, Scott M Damrauer, Million Veteran Program, Karl Michaëlsson, Stephen Burgess
May 05, 2020
AIMS: The aim of this study was to use Mendelian randomization (MR) to determine the causality of the association between smoking and 14 different cardiovascular diseases (CVDs). METHODS AND RESULTS: Our primary genetic...
cardiovascular disease lifestyle Mendelian randomization Risk Factors SINGLE-NUCLEOTIDE POLYMORPHISMS Smoking Brain Ischemia Cardiovascular Diseases Genetic Predisposition to Disease Genome-Wide Association Study Humans Mendelian Randomization Analysis Polymorphism Single Nucleotide Risk Factors Smoking stroke
Interpreting CT perfusion in stroke.
CT perfusion images can be rapidly obtained on all modern CT scanners and easily incorporated into an acute stroke imaging protocol. Here we discuss the technique of CT perfusion imaging, how to interpret the data and how it can...
Knockout of the P2Y6 Receptor Prevents Peri-Infarct Neuronal Loss after Transient, Focal Ischemia in Mouse Brain.
After stroke, there is a delayed neuronal loss in brain areas surrounding the infarct, which may in part be mediated by microglial phagocytosis of stressed neurons. Microglial phagocytosis of stressed or damaged neurons can be...
Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomization study.
Carotid Intima-Media Thickness Coronary Artery Disease Inflammation Mendelian randomization Periodontitis Risk factor stroke Atherosclerosis Brain Ischemia Carotid Intima-Media Thickness Coronary Artery Disease Genome-Wide Association Study Humans ischemic stroke Mendelian Randomization Analysis Periodontitis Polymorphism Single Nucleotide Risk Factors stroke
Accelerated FEV1 decline and risk of cardiovascular disease and mortality in a primary care population of COPD patients.
Hannah R Whittaker, Chloe Bloom, Ann Morgan, Deborah Jarvis, Steven J Kiddle, Jennifer K Quint
Oct 21, 2020
Accelerated lung function decline has been associated with increased risk of cardiovascular disease (CVD) in a general population, but little is known about this association in chronic obstructive pulmonary disease (COPD). We...
Accelerated development of cerebral small vessel disease in young stroke patients.
Renate M Arntz, Steffen MA van den Broek, Inge WM van Uden, Mohsen Ghafoorian, Bram Platel, Loes CA Rutten-Jacobs, Noortje AM Maaijwee, Pauline Schaapsmeerders, Hennie C Schoonderwaldt, Ewoud J van Dijk, Frank-Erik de Leeuw
Jun 29, 2016
Stroke in COVID-19
BACKGROUND: Coronavirus disease 2019 (COVID-19) has become a global pandemic, affecting millions of people. However, the relationship between COVID-19 and acute cerebrovascular diseases is unclear. AIMS: We aimed to characterize...
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.
Amand F Schmidt, Michael V Holmes, David Preiss, Daniel I Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hypponen, Christine Power, Max Moldovan, Erik van Iperen, Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Christina M Lill, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G Panayiotou, N Charlotte Onland-Moret, Yvonne T van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J Wareham, Claudia Langenberg, Robert A Scott, Jian'an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Tine Jess, Jackie Cooper, Steve E Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S Carrell, Catherine A McCarty, Kirchner H Lester, Eric B Larson, David R Crosslin, Mariza de Andrade, Dan M Roden, Joshua C Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Rodney Scott, Peter Schofield, Martin O'Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M Abdullah Said, Ruben N Eppinga, Niek Verweij, Harold Snieder, Lifelines Cohort authors, Tim Christen, DO Mook-Kanamori, ICBP Consortium, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P Pell, Tom Meade, Ingrid E Christophersen, Anke H Maitland-van der Zee, Ekaterina V Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L Bots, Diederick E Grobbee, Philippe Froguel, Dorothée Thuillier, Ronan Roussel, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Jemma C Hopewell, Sudha Seshadri, METASTROKE Consortium of the ISGC, Caroline Dale, Rui Providencia E Costa, Paul M Ridker, Daniel I Chasman, Alex P Reiner, Marylyn D Ritchie, Leslie A Lange, Alex J Cornish, Sara E Dobbins, Kari Hemminki, Ben Kinnersley, Marc Sanson, Karim Labreche, Matthias Simon, Melissa Bondy, Philip Law, Helen Speedy, James Allan, Ni Li, Molly Went, Niels Weinhold, Gareth Morgan, Pieter Sonneveld, Björn Nilsson, Hartmut Goldschmidt, Amit Sud, Andreas Engert, Markus Hansson, Harry Hemingway, Folkert W Asselbergs, Riyaz S Patel, Brendan J Keating, Naveed Sattar, Richard Houlston, Juan P Casas, Aroon D Hingorani
Aug 22, 2019
Genetic Association Studies LDL-cholesterol Mendelian randomisation Phenome-wide association scan Anticholesteremic Agents Biomarkers Brain Ischemia Cholesterol LDL Down-Regulation Dyslipidemias Genome-Wide Association Study Humans Myocardial Infarction PCSK9 Inhibitors Polymorphism Single Nucleotide Proprotein Convertase 9 Randomized Controlled Trials as Topic Risk Assessment Risk Factors Serine Proteinase Inhibitors stroke Treatment Outcome
Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages.
Ozayra Sharmin, Ariful Haque Abir, Abdullah Potol, Mahabub Alam, Jewel Banik, AFM Towheedur Rahman, Nuzhat Tarannum, Rasiqh Wadud, Zaki Farhad Habib, Mahbubur Rahman
Jun 10, 2021
Pamoic acid is a potent ligand for G protein Coupled Receptor 35 (GPR35) and exhibits antinociceptive property. GPR35 activation leads to increased energy utilization and the expression of anti-inflammatory genes. However, its...
Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.
John W Cole, Huichun Xu, Kathleen Ryan, Thomas Jaworek, Nicole Dueker, Patrick McArdle, Brady Gaynor, Yu-Ching Cheng, Jeffrey O'Connell, Steve Bevan, Rainer Malik, Naveed Uddin Ahmed, Philippe Amouyel, Sheraz Anjum, Joshua C Bis, David Crosslin, John Danesh, Stefan T Engelter, Myriam Fornage, Philippe Frossard, Christian Gieger, Anne-Katrin Giese, Caspar Grond-Ginsbach, Weang Kee Ho, Elizabeth Holliday, Jemma Hopewell, M Hussain, W Iqbal, S Jabeen, Jim Jannes, Ayeesha Kamal, Yoichiro Kamatani, Sandip Kanse, Manja Kloss, Mark Lathrop, Didier Leys, Arne Lindgren, WT Longstreth, Khalid Mahmood, Christa Meisinger, Tiina M Metso, Thomas Mosley, Martina Müller-Nurasyid, Bo Norrving, Eugenio Parati, Annette Peters, Alessandro Pezzini, I Quereshi, Asif Rasheed, A Rauf, T Salam, Jess Shen, Agnieszka Słowik, Tara Stanne, Konstantin Strauch, Turgut Tatlisumak, Vincent N Thijs, Steffen Tiedt, Matthew Traylor, Melanie Waldenberger, Matthew Walters, Wei Zhao, Giorgio Boncoraglio, Stéphanie Debette, Christina Jern, Christopher Levi, Hugh Markus, James Meschia, Arndt Rolfs, Peter Rothwell, Danish Saleheen, Sudha Seshadri, Pankaj Sharma, Cathie Sudlow, Bradford Worrall, METASTROKE Consortium of the ISGC, WTCCC-2 Consortium, O Colin Stine, Steven J Kittner, Braxton D Mitchell
Dec 11, 2018
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