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Results: 9
Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.
Edward J Needham, Alexander L Ren, Richard J Digby, Emma J Norton, Soraya Ebrahimi, Joanne G Outtrim, Doris A Chatfield, Anne E Manktelow, Maya M Leibowitz, Virginia FJ Newcombe, Rainer Doffinger, Gabriela Barcenas-Morales, Claudia Fonseca, Michael J Taussig, Rowan M Burnstein, Romit J Samanta, Cordelia Dunai, Nyarie Sithole, Nicholas J Ashton, Henrik Zetterberg, Magnus Gisslén, Arden Edén, Emelie Marklund, Peter JM Openshaw, Jake Dunning, Michael J Griffiths, Jonathan Cavanagh, Gerome Breen, Sarosh R Irani, Anne Elmer, Nathalie Kingston, Charlotte Summers, John R Bradley, Leonie S Taams, Benedict D Michael, Edward T Bullmore, Kenneth GC Smith, Paul A Lyons, Alasdair J Coles, David K Menon, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility
Oct 06, 2022
COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms is common, and is seemingly unrelated to COVID-19...
Relationship of admission blood proteomic biomarkers levels to lesion type and lesion burden in traumatic brain injury
Daniel P Whitehouse, Miguel Monteiro, Endre Czeiter, Thijs Vande Vyvere, Fernanda Valerio, Zheng Ye, Krisztina Amrein, Konstantinos Kamnitsas, Haiyan Xu, Zhihui Yang, Jan Verheyden, Tilak Das, Evgenios N Kornaropoulos, Ewout Steyerberg, Andrew IR Maas, Kevin KW Wang, András Büki, Ben Glocker, David K Menon, Virginia FJ Newcombe, CENTER-TBI Participants and Investigators
Jan 28, 2022
BACKGROUND: We aimed to understand the relationship between serum biomarker concentration and lesion type and volume found on computed tomography (CT) following all severities of TBI. METHODS: Concentrations of six serum...
An overview of clinical cerebral microdialysis in acute brain injury.
Matthew G Stovell, Adel Helmy, Eric P Thelin, Ibrahim Jalloh, Peter J Hutchinson, Keri LH Carpenter
Mar 07, 2023
Do ICP-Derived Parameters Differ in Vegetative State from Other Outcome Groups After Traumatic Brain Injury?
Marek Czosnyka, Joseph Donnelly, Leanne Calviello, Peter Smielewski, David K Menon, John D Pickard
Jul 20, 2018
OBJECTIVE: In nearly 1,000 traumatic brain injury (TBI) patients monitored in the years 1992-2014, we identified 18 vegetative state (VS) cases. Our database provided access to continuous computer-recorded signals, which we used...
Brain injury Intracranial Pressure outcome Slow waves Vegetative state Arterial Pressure Brain Injuries Traumatic Case-Control Studies Cerebrovascular Circulation Glasgow Outcome Scale Humans Intracranial Hypertension Intracranial Pressure Outcome Assessment Health Care Persistent Vegetative State Prognosis
An overview of clinical cerebral microdialysis in acute brain injury.
Matthew G Stovell, Adel Helmy, Eric P Thelin, Ibrahim Jalloh, Peter J Hutchinson, Keri L H Carpenter
Apr 09, 2023
Cerebral microdialysis may be used in patients with severe brain injury to monitor their cerebral physiology. In this article we provide a concise synopsis with illustrations and original images of catheter types, their...
Brain injury Neurocritical care subarachnoid hemorrhage (SAH) Traumatic Brain Injury (TBI) Cerebral microdialysis cerebral physiology
Published by: Frontiers in neurology
Non-Invasive Pressure Reactivity Index Using Doppler Systolic Flow Parameters
Frederick A Zeiler, Peter Smielewski, Andrew Stevens, Marek Czosnyka, David K Menon, Ari Ercole
Oct 03, 2018
The goal was to predict pressure reactivity index (PRx) using non-invasive transcranial Doppler (TCD) based indices of cerebrovascular reactivity, systolic flow index (Sx_a), and mean flow index (Mx_a). Continuous extended...
Incidence and prevalence of coma in the UK and the USA.
Daniel Kondziella, Moshgan Amiri, Marwan H Othman, Ettore Beghi, Yelena G Bodien, Giuseppe Citerio, Joseph T Giacino, Stephan A Mayer, Thomas N Lawson, David K Menon, Verena Rass, Tarek Sharshar, Robert D Stevens, Lorenzo Tinti, Paul Vespa, Molly McNett, Chethan P Venkatasubba Rao, Raimund Helbok, Curing Coma Campaign collaborators
Oct 24, 2022
Multimodal non-invasive assessment of intracranial hypertension
Chiara Robba, Selene Pozzebon, Bedrana Moro, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone
Jun 26, 2021
BACKGROUND: Although placement of an intra-cerebral catheter remains the gold standard method for measuring intracranial pressure (ICP), several non-invasive techniques can provide useful estimates. The aim of this study was to...
Brain injury Neuro-ICU Non-invasive intracranial pressure optic nerve sheath diameter Pupillometer Adult Analysis of Variance Area Under Curve Brain Injuries Traumatic Female Humans Intracranial Hypertension Male Middle Aged Monitoring Physiologic ROC Curve Sensitivity and Specificity Ultrasonography Doppler Transcranial
Multimodal non-invasive assessment of intracranial hypertension
Chiara Robba, Selene Pozzebon, Bedrana Moro, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone
Jun 26, 2020
Abstract: Background: Although placement of an intra-cerebral catheter remains the gold standard method for measuring intracranial pressure (ICP), several non-invasive techniques can provide useful estimates. The aim of this...