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The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription
A Akay, T Di Domenico, KM Suen, A Nabih, GE Parada, M Larance, R Medhi, Berkyurek, X Zhang, CJ Wedeles, Rudolph, J Engelhardt, M Hemberg, P Ma, AI Lamond, JM Claycomb, Miska
Jul 16, 2017
Benchmarked approaches for reconstruction of in vitro cell lineages and in silico models of C. elegans and M. musculus developmental trees.
Wuming Gong, Alejandro A Granados, Jingyuan Hu, Matthew G Jones, Ofir Raz, Irepan Salvador-Martínez, Hanrui Zhang, Ke-Huan K Chow, Il-Youp Kwak, Renata Retkute, Alidivinas Prusokas, Augustinas Prusokas, Alex Khodaverdian, Richard Zhang, Suhas Rao, Robert Wang, Phil Rennert, Vangala G Saipradeep, Naveen Sivadasan, Aditya Rao, Thomas Joseph, Rajgopal Srinivasan, Jiajie Peng, Lu Han, Xuequn Shang, Daniel J Garry, Thomas Yu, Verena Chung, Michael Mason, Zhandong Liu, Yuanfang Guan, Nir Yosef, Jay Shendure, Maximilian J Telford, Ehud Shapiro, Michael B Elowitz, Pablo Meyer
Jun 25, 2021
The recent advent of CRISPR and other molecular tools enabled the reconstruction of cell lineages based on induced DNA mutations and promises to solve the ones of more complex organisms. To date, no lineage reconstruction...
Comparative Epigenomics Reveals that RNA Polymerase II Pausing and Chromatin Domain Organization Control Nematode piRNA Biogenesis.
Toni Beltran, Consuelo Barroso, Timothy Y Birkle, Lewis Stevens, Hillel T Schwartz, Paul W Sternberg, Hélène Fradin, Kristin Gunsalus, Fabio Piano, Garima Sharma, Chiara Cerrato, Julie Ahringer, Enrique Martínez-Pérez, Mark Blaxter, Peter Sarkies
Apr 01, 2019
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.
Olga Sin, Tristan de Jong, Alejandro Mata-Cabana, Michelle Kudron, Mohamad Amr Zaini, Francesco A Aprile, Renée I Seinstra, Esther Stroo, Roméo Willinge Prins, Céline N Martineau, Hai Hui Wang, Wytse Hogewerf, Anne Steinhof, Erich E Wanker, Michele Vendruscolo, Cornelis F Calkhoven, Valerie Reinke, Victor Guryev, Ellen AA Nollen
Sep 09, 2019
Protein aggregation is associated with age-related neurodegenerative disorders, such as Alzheimer's and polyglutamine diseases. As a causal relationship between protein aggregation and neurodegeneration remains elusive...
C. elegans MOAG-2/LIR-3 RNA Polymerase III Non-coding RNA polyglutamine protein aggregation Protein homeostasis protein quality control snoRNA tRNA Active Transport Cell Nucleus Animals Animals Genetically Modified Binding Sites Caenorhabditis elegans Caenorhabditis elegans Proteins Cell Nucleus Cytosol Disease Models Animal Neurodegenerative Diseases Peptides Promoter Regions Genetic Protein Aggregates protein aggregation Pathological Protein Binding RNA Interference RNA Polymerase III RNA Small Untranslated Transcription Factors Transcription Genetic
Natural Genetic Variation in a Multigenerational Phenotype in C. elegans.
Although heredity mostly relies on the transmission of DNA sequence, additional molecular and cellular features are heritable across several generations. In the nematode Caenorhabditis elegans, insights into such unconventional...
IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans.
Anikó I Nagy, Rafael P Vázquez-Manrique, Marie Lopez, Christo P Christov, María Dolores Sequedo, Mareike Herzog, Anna E Herlihy, Maxime Bodak, Roxani Gatsi, Howard A Baylis
Feb 19, 2015
C. elegans RNA Interference calcium signalling enhanced RNAi Inositol 1 4 5‐trisphosphate Animals Caenorhabditis elegans Image Processing Computer-Assisted Inositol 1 4 5-Trisphosphate Intestinal Mucosa Microscopy Fluorescence Models Biological RNA Interference RNA Double-Stranded Signal Transduction