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Results: 71
DRE-1/FBXO11, A Conserved F Box Protein, Regulates Apoptosis in C. elegans and is Mutated in Human Lymphoma
Michael Chiorazzi
Jan 01, 0001
In the course of metazoan embryonic and post-embryonic development, more cells are generated than exist in the mature organism, and these cells are deleted by the process of programmed cell death. In addition, cells can be...
Published by: Rockefeller University
The DREAM complex promotes gene body H2A.Z for target repression.
Isabel Latorre, Michael A Chesney, Jacob M Garrigues, Przemyslaw Stempor, Alex Appert, Mirko Francesconi, Susan Strome, Julie Ahringer
Jul 24, 2015
The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells.
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease
Michele Perni, Annemieke van der Goot, Ryan Limbocker, Tjakko J. van Ham, Francesco A. Aprile, Catherine K. Xu, Patrick Flagmeier, Karen Thijssen, Pietro Sormanni, Giuliana Fusco, Serene W. Chen, Pavan K. Challa, Julius B. Kirkegaard, Romain F. Laine, Kai Yu Ma, Martin B. D. Müller, Tessa Sinnige, Janet R. Kumita, Samuel I. A. Cohen, Renée Seinstra, Gabriele S. Kaminski Schierle, Clemens F. Kaminski, Denise Barbut, Alfonso De Simone, Tuomas P. J. Knowles, Michael Zasloff, Ellen A. A. Nollen, Michele Vendruscolo, Christopher M. Dobson
Apr 05, 2021
The aggregation of α-synuclein is a hallmark of Parkinson's disease (PD) and a variety of related neurological disorders. A number of mutations in this protein, including A30P and A53T, are associated with familial forms of the...
A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress.
Alicia N McMurchy, Przemyslaw Stempor, Tessa Gaarenstroom, Brian Wysolmerski, Yan Dong, Darya Aussianikava, Alex Appert, Ni Huang, Paulina Kolasinska-Zwierz, Alexandra Sapetschnig, Eric A Miska, Julie Ahringer
Aug 17, 2017
Repetitive sequences derived from transposons make up a large fraction of eukaryotic genomes and must be silenced to protect genome integrity. Repetitive elements are often found in heterochromatin; however, the roles and...
C. elegans DNA Damage Chromosomes evolutionary biology Genes Genomics Germ line Heterochromatin nuclear RNAi piRNA repetitive elements Animals Apoptosis Caenorhabditis elegans Caenorhabditis elegans Proteins Chromosomal Proteins Non-Histone DNA Repair Gene Expression Regulation Germ Cells Heterochromatin Interspersed Repetitive Sequences RNA Interference RNA Small Interfering
Chromatin accessibility dynamics across C. elegans development and ageing.
Jürgen Jänes, Yan Dong, Michael Schoof, Jacques Serizay, Alex Appert, Chiara Cerrato, Carson Woodbury, Ron Chen, Carolina Gemma, Ni Huang, Djem Kissiov, Przemyslaw Stempor, Annette Steward, Eva Zeiser, Sascha Sauer, Julie Ahringer
Feb 04, 2019
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease.
Michele Perni, Annemieke van der Goot, Ryan Limbocker, Tjakko J van Ham, Francesco A Aprile, Catherine K Xu, Patrick Flagmeier, Karen Thijssen, Pietro Sormanni, Giuliana Fusco, Serene W Chen, Pavan K Challa, Julius B Kirkegaard, Romain F Laine, Kai Yu Ma, Martin BD Müller, Tessa Sinnige, Janet R Kumita, Samuel IA Cohen, Renée Seinstra, Gabriele S Kaminski Schierle, Clemens F Kaminski, Denise Barbut, Alfonso De Simone, Tuomas PJ Knowles, Michael Zasloff, Ellen AA Nollen, Michele Vendruscolo, Christopher M Dobson
May 07, 2021
The aggregation of α-synuclein is a hallmark of Parkinson's disease (PD) and a variety of related neurological disorders. A number of mutations in this protein, including A30P and A53T, are associated with familial forms of the...
Comparing Centrosome Behavior in Wild-Type and pam-1 Mutant One-Celled Caenorhabditis elegans Embryos
Devayu A. Parikh
Jan 01, 0001
Polarization occurs in all organisms and is fundamental to specifying various cell fates and achieving functional potential. In one-cell C. elegans embryos, polarization, characterized by a first asymmetric division, establishes...
Published by: Ursinus College
Identification and Phenotypic Analysis of the lz5 Suppressor of the pam-1 Mutation in C. elegans
Dorothy A Benton
Jan 01, 0001
The anterior-posterior axis in the C. elegans embryo is set up in the one-cell embryo stage and results in an asymmetric cell division, creating two differently sized daughter cells. One of the genes involved in axis...
Published by: Ursinus College
Characterization and Identification of the lz5 Suppressor of pam-1 in C. elegans
Dorothy A Benton
Jan 01, 0001
The anterior-posterior axis in the C. elegans embryo is set up after the first asymmetric cell division creates two differently sized daughter cells. One of the genes involved is pam-1, which codes for a puromycin-sensitive...
C. elegans symmetry Cell Polarity Mutation suppressors Biology Cell Biology developmental biology Genetics Life Sciences
Published by: Ursinus College
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.
Massimiliano Runfola, Michele Perni, Xiaoting Yang, Maria Marchese, Andrea Bacci, Serena Mero, Filippo M Santorelli, Beatrice Polini, Grazia Chiellini, Daniela Giuliani, Antonietta Vilella, Martina Bodria, Eleonora Daini, Eleonora Vandini, Simon Rudge, Sheraz Gul, Michale OJ Wakelam, Michele Vendruscolo, Simona Rapposelli
Jan 28, 2022
The identification of effective pharmacological tools for Alzheimer's disease (AD) represents one of the main challenges for therapeutic discovery. Due to the variety of pathological processes associated with AD, a promising...
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.
Massimiliano Runfola, Michele Perni, Xiaoting Yang, Maria Marchese, Andrea Bacci, Serena Mero, Filippo M Santorelli, Beatrice Polini, Grazia Chiellini, Daniela Giuliani, Antonietta Vilella, Martina Bodria, Eleonora Daini, Eleonora Vandini, Simon Rudge, Sheraz Gul, Michale OJ Wakelam, Michele Vendruscolo, Simona Rapposelli
Jan 05, 2022
The identification of effective pharmacological tools for Alzheimer's disease (AD) represents one of the main challenges for therapeutic discovery. Due to the variety of pathological processes associated with AD, a promising...
Identification of functional long non-coding RNAs in C. elegans.
Alper Akay, David Jordan, Isabela Cunha Navarro, Tomasz Wrzesinski, Chris P Ponting, Eric A Miska, Wilfried Haerty
May 09, 2019
BACKGROUND: Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in the...
Genetic Variation in Complex Traits in Transgenic α-Synuclein Strains of Caenorhabditis elegans.
Different genetic backgrounds can modify the effect of mutated genes. Human α-synuclein (SNCA) gene encodes α-synuclein, and its oligomeric complexes accumulate with age and mediate the disruption of cellular homeostasis...
C. elegans Genetic background protein accumulation α-synuclein Animals Animals Genetically Modified Bacterial Proteins Body Size Caenorhabditis elegans Disease Models Animal Gene Expression Regulation genetic variation Genome Humans Luminescent Proteins Lysosomes Multifactorial Inheritance Parkinson Disease Transcription Genetic ALPHA-SYNUCLEIN
Visualizing formation of the active site in the mitochondrial ribosome.
Viswanathan Chandrasekaran, Nirupa Desai, Nicholas O Burton, Hanting Yang, Jon Price, Eric A Miska, V Ramakrishnan
Nov 05, 2021
human Biochemistry C. elegans structural biology chemical biology cryo-EM RNA modifications peptidyl transferase center molecular biophysics mitochondrial ribosome
Published by: eLife
Visualizing formation of the active site in the mitochondrial ribosome
Viswanathan Chandrasekaran, Nirupa Desai, Nicholas O Burton, Hanting Yang, Jon Price, Eric A Miska, V Ramakrishnan
Oct 05, 2021
Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs
Nicholas O Burton, Alexandra Willis, Kinsey Fisher, Fabian Braukmann, Jonathan Price, Lewis Stevens, L Ryan Baugh, Aaron Reinke, Eric A Miska
Nov 05, 2021
Multi-Omics and Genome-Scale Modeling Reveal a Metabolic Shift During C. elegans Aging.
Janna Hastings, Abraham Mains, Bhupinder Virk, Nicolas Rodriguez, Sharlene Murdoch, Juliette Pearce, Sven Bergmann, Nicolas Le Novère, Olivia Casanueva
Jul 01, 2019
In this contribution, we describe a multi-omics systems biology study of the metabolic changes that occur during aging in Caenorhabditis elegans. Sampling several time points from young adulthood until early old age, our study...
Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states.
Iris Hardege, Julia Morud, Jingfang Yu, Tatiana S Wilson, Frank C Schroeder, William R Schafer
Jan 12, 2023
Does Using wee-1.3 as a Secondary Suppressor Restore Wildtype Timing of Meiosis and Oocyte Maturation in pam-1 C. elegans Mutants?
Caprice Eisele
Jan 01, 0001
I investigated the relationship between two developmental proteins, PAM-1 and WEE-1.3. WEE-1.3 is an inhibitory kinase that regulates a maturation promoting complex called CDK-1, and is responsible for timely oocyte development....
Published by: Ursinus College
Does Using wee-1.3 as a Secondary Suppressor Restore Wildtype Timing of Meiosis and Oocyte Maturation in pam-1 C. elegans Mutants?
Caprice Eisele
Jan 01, 0001
The puromycin-sensitive aminopeptidase, PAM-1, is crucial for polarity establishment, pseudocleavage, and symmetric division, all of which are clear signs of viable development of one cell C. elegans embryos. We have found...
Published by: Ursinus College
Location and Characterization of the lz2 Suppressor of pam-1 in C. elegans
Alyse N. Brewer
Jan 01, 0001
In a single-celled Caenorhabditis elegans, the anterior posterior axis is established when the sperm-donated centrosome meets the posterior cortex, which is fundamental for proper development. pam-1 encodes for the protein...
Cell Polarity C. elegans suppressors anterior posterior axis snp mapping Biology developmental biology Life Sciences
Published by: Ursinus College
Hypoxia signalling and regulation in chemosensory behaviour of<i> Caenorhabditis elegans</i>
Adaptation to hypoxia is essential to survival in most organisms; disruption of oxygen homeostasis is linked to the pathology of multiple diseases including neurodegeneration, ischaemic stroke and cancer. Hypoxia-inducible...
The Long-Rage Directional Behavior of the Nematode C. Elegans
Margherita Peliti
Jan 01, 0001
Like any mobile organism, C. elegans relies on sensory cues to find food. In the absence of such cues, animals might display defined search patterns or other stereotyped behavior. The motion of C. elegans has previously been...
C. elegans directional behavior off-food trajectories random walk processes daf-19 mutants Life Sciences
Published by: Rockefeller University
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