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CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function.
Sarah K Whiteside, Francis M Grant, David S Gyori, Alberto G Conti, Charlotte J Imianowski, Paula Kuo, Rabab Nasrallah, Firas Sadiyah, Sergio A Lira, Frank Tacke, Robert L Eil, Oliver T Burton, James Dooley, Adrian Liston, Klaus Okkenhaug, Jie Yang, Rahul Roychoudhuri
May 10, 2021
CD4+ regulatory T (Treg) cells, dependent upon the transcription factor Foxp3, contribute to tumour immunosuppression but are also required for immune homeostasis. There is interest in developing therapies that selectively...
CCR8 CD4+ T cells CD8+ T cells FOXP3 Treg Cancer Immunotherapy Adenocarcinoma Animals Colorectal Neoplasms Forkhead Transcription Factors Humans Immune Tolerance Lymphocytes Tumor-Infiltrating Melanoma Melanoma Experimental Mice Mice Inbred C57BL Mice Knockout Receptors CCR8 Skin Neoplasms T-Lymphocytes Regulatory