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CD80+CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells
Foxp3+CD25+CD4+ regulatory T cells (Treg) mediate immunological self-tolerance and suppress immune responses. A subset of dendritic cells (DCs) in the intestine is specialized to induce Treg in a TGF-?- and retinoic...
CD4 antigen CD8 antigen FOXP3+ regulatory T lymphocyte dendritic cell Cell Differentiation Spleen Transgenic mouse
Published by: Rockefeller University
Mature dendritic cells boost functionally superior CD8+ T-cell in humans without foreign helper epitopes
We have recently shown that a single injection of mature, antigen- pulsed, human dendritic cells (DCs) rapidly elicits CD4+ and CD8+ T-cell immunity in vivo. The DCs were pulsed with 2 foreign proteins, keyhole limpet hemocyanin...
CD8 antigen cytotoxic T lymphocy tedendritic cell Immunization helper cell T lymphocyte subpopulation
Published by: Rockefeller University
Specialized role of migratory dendritic cells in peripheral tolerance induction
Harnessing DCs for immunotherapies in vivo requires the elucidation of the physiological role of distinct DC populations. Migratory DCs traffic from peripheral tissues to draining lymph nodes charged with tissue self antigens....
CD8 antigen langerin cell migration dendritic cell molecularly targeted therapy Langerhans Cells regulatory T lymphocyte
Published by: Rockefeller University
The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo
Dendritic cells (DCs) are able in tissue culture to phagocytose and present antigens derived from infected, malignant, and allogeneic cells. Here we show directly that DCs in situ take up these types of cells after fluorescent...
Published by: Rockefeller University