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Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing.
Jan Attig, Federico Agostini, Clare Gooding, Anob M Chakrabarti, Aarti Singh, Nejc Haberman, Julian A Zagalak, Warren Emmett, Christopher WJ Smith, Nicholas M Luscombe, Jernej Ule
Sep 18, 2019
Long mammalian introns make it challenging for the RNA processing machinery to identify exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection by recruiting dozens of RNA-binding proteins...
CLIP LINE repeats MATR3 PTBP1 alternative polyadenylation cryptic exons evolution exonogenesis multivalency splicing Alternative Splicing Animals Binding Sites Exons HeLa Cells Heterogeneous-Nuclear Ribonucleoproteins Humans Introns Long Interspersed Nucleotide Elements Mice Mutation Nuclear Matrix-Associated Proteins Nucleotide Motifs Phylogeny Polyadenylation Polypyrimidine Tract-Binding Protein Protein Binding Protein Interaction Mapping RNA RNA Splicing RNA-Binding Proteins