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A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity.
Katharina Koch, Rudolf Hartmann, Julia Tsiampali, Constanze Uhlmann, Ann-Christin Nickel, Xiaoling He, Marcel A Kamp, Michael Sabel, Roger A Barker, Hans-Jakob Steiger, Daniel Hänggi, Dieter Willbold, Jaroslaw Maciaczyk, Ulf D Kahlert
Apr 20, 2020
Cancer cells upregulate anabolic processes to maintain high rates of cellular turnover. Limiting the supply of macromolecular precursors by targeting enzymes involved in biosynthesis is a promising strategy in cancer therapy....