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Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance
Anne Ramsay Bowden, David A Morales-Juarez, Matylda Sczaniecka-Clift, Maria Martin Agudo, Natalia Lukashchuk, John Christopher Thomas, Stephen P Jackson
May 23, 2020
CRISPR-Cas9 genome engineering has revolutionised high-throughput functional genomic screens. However, recent work has raised concerns regarding the performance of CRISPR-Cas9 screens using TP53 wild-type human cells due to a...