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TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit.
Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish infected with Mycobacterium marinum or...
BAX Calcium ER ROS TNF-mediated necrosis Calcium Channel Blockers macrophage Mitochondrion ryanodine receptors Tuberculosis Animals Apoptosis Calcium Endoplasmic Reticulum Humans Lysosomes MACROPHAGES Membrane potential Mitochondrial Mitochondria Mycobacterium Infections Nontuberculous Mycobacterium marinum Mycobacterium tuberculosis Necrosis Reactive Oxygen Species THP-1 Cells Tuberculosis Tumor Necrosis Factor-alpha Zebrafish
Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2
Bryan Williams, Thomas M MacDonald, Mark Caulfield, J Kennedy Cruickshank, Gordon McInnes, Peter Sever, David J Webb, Jackie Salsbury, Steve Morant, Ian Ford, Morris J Brown
Sep 02, 2015
Drug Treatment Resistant hypertension Adolescent Adult Aged Algorithms Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors Antihypertensive Agents Calcium Channel Blockers Clinical Protocols Cross-Over Studies Diuretics Double-Blind Method Drug Therapy Combination Humans Hypertension Male Middle Aged Spironolactone Young Adult
Blood Pressure Changes Following Antihypertensive Medication Reduction, by Drug Class and Dose Chosen for Withdrawal
James P Sheppard, Mark Lown, Jenni Burt, Gary A Ford, FD Richard Hobbs, Paul Little, Jonathan Mant, Rupert A Payne, Richard J McManus, OPTiMISE Investigators
Mar 05, 2021
Blood Pressure Changes Following Antihypertensive Medication Reduction, by Drug Class and Dose Chosen for Withdrawal
James P. Sheppard, Mark Lown, Jenni Burt, Gary A. Ford, F. D. Richard Hobbs, Paul Little, Jonathan Mant, Rupert A. Payne, Richard J. McManus, On behalf of the OPTiMISE Investigators
May 04, 2021
Aims: Deprescribing of antihypertensive drugs is recommended for some older patients with polypharmacy, but there is little evidence to inform which drug (or dose) should be withdrawn. This study used data from the OPTiMISE...
Dendritic Ca2+ dynamics and multimodal processing in a cricket antennal interneuron.
Ca2+ imaging dendritic processing multimodal stimulation Action Potentials Animals Arthropod Antennae Brain Cadmium Calcium Calcium Channel Blockers Calcium Channels Calcium Signaling Dendrites Female Flagella Gryllidae Interneurons Male Optical Imaging Photic Stimulation Potassium Channels Calcium-Activated Touch
Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels.
Tiago Rodrigues, Florian Sieglitz, Víctor J Somovilla, Pedro MSD Cal, Antony Galione, Francisco Corzana, Gonçalo JL Bernardes
Jul 06, 2016
Safety of beta-blocker and calcium channel blocker antihypertensive drugs in pregnancy
Maddalena Ardissino, Eric AW Slob, Skanda Rajasundaram, Rohin K Reddy, Benjamin Woolf, Joanna Girling, Mark R Johnson, Fu Siong Ng, Dipender Gill
Oct 06, 2022
Beta-blocker blood pressure Calcium channel blocker Mendelian randomization Pregnancy Adrenergic beta-Antagonists Antihypertensive Agents Birth Weight Calcium Channel Blockers Child Diabetes Gestational Eclampsia Female Genome-Wide Association Study Humans Hypertension Mendelian Randomization Analysis pre-eclampsia Pregnancy Pregnancy Complications
A randomised, double-blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model
Michael C Lee, Simon Bond, Daniel Wheeler, Ingrid Scholtes, Graham Armstrong, Peter McNaughton, David Menon
Jun 17, 2019
In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancer.
Ruthenium complexes offer the potential of reduced toxicity, a novel mechanism of action, non-cross resistance and a different spectrum of activity compared to platinum containing compounds. Thirteen novel ruthenium(II)...
ATP Binding Cassette Transporter Subfamily B Member 1 Animals Antimetabolites Antineoplastic Antineoplastic Agents Azacitidine Calcium Channel Blockers Carboplatin cisplatin Decitabine Drug Design Drug Resistance Multiple Drug Resistance Neoplasm Drug Screening Assays Antitumor Edetic Acid Female Humans Ligands Mice Mice Nude Neoplasm Proteins Organometallic Compounds Ovarian Neoplasms Ruthenium Compounds Structure-Activity Relationship Verapamil Xenograft Model Antitumor Assays
Currently prescribed drugs in the UK that could upregulate or downregulate ACE2 in COVID-19 disease
Hajira Dambha-Miller, Ali Albasri, Sam Hodgson, Christopher R Wilcox, Shareen Khan, Nazrul Islam, Paul Little, Simon J Griffin
Sep 16, 2020
Adverse events Public Health respiratory infections Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme 2 Angiotensin-Converting Enzyme Inhibitors Anti-Inflammatory Agents Non-Steroidal Betacoronavirus covid-19 Calcium Channel Blockers Coronavirus Infections Down-Regulation Estrogens Glucagon-Like Peptide 1 Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypoglycemic Agents Insulin Mineralocorticoid Receptor Antagonists Pandemics Peptidyl-Dipeptidase A Pneumonia Viral SARS-CoV-2 Thiazolidinediones United Kingdom Up-Regulation