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Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex.
Laith Alexander, Philip LR Gaskin, Stephen J Sawiak, Tim D Fryer, Young T Hong, Gemma J Cockcroft, Hannah F Clarke, Angela C Roberts
Dec 21, 2018
Anhedonia is a core symptom of depression, but the underlying neurobiological mechanisms are unknown. Correlative neuroimaging studies implicate dysfunction within ventromedial prefrontal cortex, but the causal roles of specific...
PET imaging Anhedonia anterior cingulate area 25 Depression Ketamine Marmoset motivation Reward subgenual Anhedonia Animals blood pressure Callithrix Citalopram Conditioning Classical discrimination Psychological Disease Models Animal Excitatory Amino Acid Antagonists Female Fluorodeoxyglucose F18 Food Preferences Gyrus Cinguli Humans Ketamine Locomotion Male Proto-Oncogene Proteins c-fos Reward Selective Serotonin Reuptake Inhibitors Stress Psychological Sucrose
A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey.
Lydia Oikonomidis, Andrea M Santangelo, Yoshiro Shiba, F Hannah Clarke, Trevor W Robbins, Angela C Roberts
Oct 28, 2016
Regional inactivations of primate ventral prefrontal cortex reveal two distinct mechanisms underlying negative bias in decision making.
Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat.
Laith Alexander, Christian M Wood, Philip LR Gaskin, Stephen J Sawiak, Tim D Fryer, Young T Hong, Lauren McIver, Hannah F Clarke, Angela C Roberts
Oct 02, 2020
Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity within area 25 of the subgenual anterior cingulate cortex (sgACC/25)...
Trajectories and Milestones of Cortical and Subcortical Development of the Marmoset Brain From Infancy to Adulthood.
SJ Sawiak, Y Shiba, L Oikonomidis, CP Windle, AM Santangelo, H Grydeland, G Cockcroft, ET Bullmore, AC Roberts
Nov 30, 2018
With increasing attention on the developmental causes of neuropsychiatric disorders, appropriate animal models are crucial to identifying causes and assessing potential interventions. The common marmoset is an ideal model as it...
Auditory artificial grammar learning in macaque and marmoset monkeys.
Benjamin Wilson, Heather Slater, Yukiko Kikuchi, Alice E Milne, William D Marslen-Wilson, Kenny Smith, Christopher I Petkov
Mar 27, 2018
Artificial grammars (AG) are designed to emulate aspects of the structure of language, and AG learning (AGL) paradigms can be used to study the extent of nonhuman animals' structure-learning capabilities. However, different AG...
D2 receptors and cognitive flexibility in marmosets
Behavioral flexibility, which allows organisms to adapt their actions in response to environmental changes, is impaired in a number of neuropsychiatric conditions, including obsessive-compulsive disorder and addiction. Studies...
Ventromedial prefrontal area 14 provides opposing regulation of threat and reward-elicited responses in the common marmoset.
Zuzanna M Stawicka, Roohollah Massoudi, Nicole K Horst, Ken Koda, Philip LR Gaskin, Laith Alexander, Andrea M Santangelo, Lauren McIver, Gemma J Cockcroft, Christian M Wood, Angela C Roberts
Sep 09, 2020
The ventromedial prefrontal cortex (vmPFC) is a key brain structure implicated in mood and anxiety disorders, based primarily on evidence from correlational neuroimaging studies. Composed of a number of brain regions with...
Hippocampal Interaction With Area 25, but not Area 32, Regulates Marmoset Approach-Avoidance Behavior.
Chloe U Wallis, Gemma J Cockcroft, Rudolf N Cardinal, Angela C Roberts, Hannah F Clarke
Feb 08, 2019
Differential Effects of the Inactivation of Anterior and Posterior Orbitofrontal Cortex on Affective Responses to Proximal and Distal Threat, and Reward Anticipation in the Common Marmoset.
Zuzanna M Stawicka, Roohollah Massoudi, Lydia Oikonomidis, Lauren McIver, Kevin Mulvihill, Shaun KL Quah, Gemma J Cockcroft, Hannah F Clarke, Nicole K Horst, Christian M Wood, Angela C Roberts
Jun 16, 2021
Structural and functional abnormalities of the orbitofrontal cortex (OFC) have been implicated in affective disorders that manifest anxiety-related symptoms. However, research into the functions of primate OFC has predominantly...
The ventromedial prefrontal cortex and emotion regulation
Neuroimaging studies implicate the ventromedial prefrontal cortex (vmPFC) in a wide range of emotional and cognitive functions, and changes in activity within vmPFC have been linked to the aetiology and successful treatment of...
A high infectious simian adenovirus type 23 vector based vaccine efficiently protects common marmosets against Zika virus infection.
Shengxue Luo, Wei Zhao, Xiaorui Ma, Panli Zhang, Bochao Liu, Ling Zhang, Wenjing Wang, Yuanzhan Wang, Yongshui Fu, Jean-Pierre Allain, Tingting Li, Chengyao Li
Feb 12, 2020
Zika virus (ZIKV) has spread in many countries or territories causing severe neurologic complications with potential fatal outcomes. The small primate common marmosets are susceptible to ZIKV, mimicking key features of human...
Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development.
Thorsten Boroviak, Giuliano G Stirparo, Sabine Dietmann, Irene Hernando-Herraez, Hisham Mohammed, Wolf Reik, Austin Smith, Erika Sasaki, Jennifer Nichols, Paul Bertone
Dec 06, 2018
Blastocyst Embryo human Inner cell mass Pluripotency primate Animals Callithrix Conserved Sequence Embryo Mammalian Embryonic Development Endoderm Epigenesis Genetic Gene Expression Profiling Gene Expression Regulation Developmental Gene Regulatory Networks Germ Layers Humans Mice Otx Transcription Factors RNA Messenger Ribosomes Single-Cell Analysis Transcription Genetic Transcriptome
Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.
Andrea M Santangelo, Steve J Sawiak, Tim Fryer, Young Hong, Yoshiro Shiba, Hannah F Clarke, Patrick J Riss, Valentina Ferrari, Roger Tait, John Suckling, Franklin I Aigbirhio, Angela C Roberts
Jun 20, 2019
Genetic variation in the serotonin transporter gene (SLC6A4) is associated with vulnerability to affective disorders and pharmacotherapy efficacy. We recently identified sequence polymorphisms in the common marmoset SLC6A4...
Anxiety insula cortex serotonin 2A receptor serotonin transporter polymorphism Animals Anxiety Behavior Animal Callithrix Cerebral Cortex Female Fluorobenzenes Genotype Humans Injections Intramuscular Male Models Animal Piperidines Polymorphism Genetic Promoter Regions Genetic RNA Receptor Serotonin 5-HT2A Serotonin 5-HT2 Receptor Antagonists Serotonin Plasma Membrane Transport Proteins Stress Psychological
Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.
Jorge L Zeredo, Shaun KL Quah, Chloe U Wallis, Laith Alexander, Gemma J Cockcroft, Andrea M Santangelo, Jing Xia, Yoshiro Shiba, Jeffrey W Dalley, Rudolf N Cardinal, Angela C Roberts, Hannah F Clarke
Jan 29, 2019
Marmoset Viral Hepatic Inflammation Induced by Hepatitis C Virus Core Protein via IL-32.
Bochao Liu, Xiaorui Ma, Qi Wang, Shengxue Luo, Ling Zhang, Wenjing Wang, Yongshui Fu, Jean-Pierre Allain, Chengyao Li, Tingting Li
May 05, 2020
Common marmosets infected with GB virus-B (GBV-B) chimeras containing hepatitis C virus (HCV) core and envelope proteins (CE1E2p7) developed more severe hepatitis than those infected with HCV envelope proteins (E1E2p7)...
Selective Role of the Putamen in Serial Reversal Learning in the Marmoset.
Stacey AW Jackson, Nicole K Horst, Sebastian FA Axelsson, Naotaka Horiguchi, Gemma J Cockcroft, Trevor W Robbins, Angela C Roberts
Dec 06, 2018
Fronto-striatal circuitry involving the orbitofrontal cortex has been identified as mediating successful reversal of stimulus-outcome contingencies. The region of the striatum that most contributes to reversal learning remains...
Serotonergic, brain volume and attentional correlates of trait anxiety in primates.
Yevheniia Mikheenko, Yoshiro Shiba, Stephen Sawiak, Katrin Braesicke, Gemma Cockcroft, Hannah Clarke, Angela C Roberts
Feb 13, 2015
Serotonin at the level of the amygdala and orbitofrontal cortex modulates distinct aspects of positive emotion in primates.
Impaired top-down regulation of the amygdala, and its modulation by serotonin (5-HT), is strongly implicated in the dysregulation of negative emotion that characterizes a number of affective disorders. However, the contribution...
Differential Contribution of Anterior and Posterior Midcingulate Subregions to Distal and Proximal Threat Reactivity in Marmosets.
Sufia S Rahman, Kevin Mulvihill, Christian M Wood, Shaun KL Quah, Nicole K Horst, Hannah F Clarke, Gemma J Cockcroft, Andrea M Santangelo, Angela C Roberts
Apr 15, 2021
Quantifying anhedonia-like symptoms in marmosets using appetitive Pavlovian conditioning.
Blunted reward responsivity is associated with anhedonia in humans and is a core feature of depression. This protocol describes how to train the common marmoset, Callithrix jacchus, on an appetitive Pavlovian conditioning...
Trait Anxiety Mediated by Amygdala Serotonin Transporter in the Common Marmoset.
High trait anxiety is associated with altered activity across emotion regulation circuitry and a higher risk of developing anxiety disorders and depression. This circuitry is extensively modulated by serotonin. Here, to...
Amygdala Anxiety emotion primate Serotonin transporter Amygdala Animals Anxiety Behavior Animal Callithrix Citalopram Emotions Exploratory Behavior Extinction Psychological Fear Female Humans Male Receptors Serotonin Serotonin Plasma Membrane Transport Proteins Selective Serotonin Reuptake Inhibitors
Region-specific microRNA alterations in marmosets carrying SLC6A4 polymorphisms are associated with anxiety-like behavior.
BACKGROUND: Psychiatric diseases such as depression and anxiety are multifactorial conditions, highly prevalent in western societies. Human studies have identified a number of high-risk genetic variants for these diseases. Among...