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Agricultural intensification and the evolution of host specialism in the enteric pathogen Campylobacter jejuni.
Evangelos Mourkas, Aidan J Taylor, Guillaume Méric, Sion C Bayliss, Ben Pascoe, Leonardos Mageiros, Jessica K Calland, Matthew D Hitchings, Anne Ridley, Ana Vidal, Ken J Forbes, Norval JC Strachan, Craig T Parker, Julian Parkhill, Keith A Jolley, Alison J Cody, Martin CJ Maiden, David J Kelly, Samuel K Sheppard
Jun 19, 2020
Modern agriculture has dramatically changed the distribution of animal species on Earth. Changes to host ecology have a major impact on the microbiota, potentially increasing the risk of zoonotic pathogens being transmitted to...
Campylobacter Adaptation evolution Genomics Recombination Adaptation Physiological agriculture Animals Biofilms Campylobacter jejuni Cattle Diet evolution Molecular Gene Transfer Horizontal Genomics homologous recombination Host Specificity Hydrophobic and Hydrophilic Interactions Mutagenesis Phenotype Recombination Genetic specialization
Motility defects in Campylobacter jejuni defined gene deletion mutants caused by second-site mutations.
Stefan PW de Vries, Srishti Gupta, Abiyad Baig, Joanna L'Heureux, Elsa Pont, Dominika P Wolanska, Duncan J Maskell, Andrew J Grant
Aug 11, 2017
Domestication of Campylobacter jejuni NCTC 11168.
Ben Pascoe, Lisa K Williams, Jessica K Calland, Guillaume Meric, Matthew D Hitchings, Myles Dyer, Joseph Ryder, Sophie Shaw, Bruno S Lopes, Cosmin Chintoan-Uta, Elaine Allan, Ana Vidal, Catherine Fearnley, Paul Everest, Justin A Pachebat, Tristan A Cogan, Mark P Stevens, Thomas J Humphrey, Thomas S Wilkinson, Alison J Cody, Frances M Colles, Keith A Jolley, Martin CJ Maiden, Norval Strachan, Bruce M Pearson, Dennis Linton, Brendan W Wren, Julian Parkhill, David J Kelly, Arnoud HM van Vliet, Ken J Forbes, Samuel K Sheppard
Aug 09, 2019
Reference and type strains of well-known bacteria have been a cornerstone of microbiology research for decades. The sharing of well-characterized isolates among laboratories has run in parallel with research efforts and enhanced...
Genome-Scale Metabolic Model Driven Design of a Defined Medium for Campylobacter jejuni M1cam.
Noemi Tejera, Lisa Crossman, Bruce Pearson, Emily Stoakes, Fauzy Nasher, Bilal Djeghout, Mark Poolman, John Wain, Dipali Singh
Jul 03, 2020
Campylobacter jejuni, the most frequent cause of food-borne bacterial gastroenteritis, is a fastidious organism when grown in the laboratory. Oxygen is required for growth, despite the presence of the metabolic mechanism for...
Multivalent poultry vaccine development using Protein Glycan Coupling Technology.
Marta Mauri, Thippeswamy H Sannasiddappa, Prerna Vohra, Ricardo Corona-Torres, Alexander A Smith, Cosmin Chintoan-Uta, Abi Bremner, Vanessa S Terra, Sherif Abouelhadid, Mark P Stevens, Andrew J Grant, Jon Cuccui, Brendan W Wren
Nov 03, 2021
Background
Poultry is the world's most popular animal-based food and global production has tripled in the past 20 years alone. Low-cost vaccines that can be combined to protect poultry against multiple infections are a...
Poultry vaccine Campylobacter jejuni Glycoconjugates Glycoengineering APEC One Health NetB Live-attenuated PGCT
Published by: Microbial cell factories
Multivalent poultry vaccine development using Protein Glycan Coupling Technology.
Marta Mauri, Thippeswamy H Sannasiddappa, Prerna Vohra, Ricardo Corona-Torres, Alexander A Smith, Cosmin Chintoan-Uta, Abi Bremner, Vanessa S Terra, Sherif Abouelhadid, Mark P Stevens, Andrew J Grant, Jon Cuccui, Brendan W Wren, Glycoengineering of Veterinary Vaccines Consortium
Sep 30, 2021
APEC Campylobacter jejuni Glycoconjugates Glycoengineering Live-attenuated NetB One Health PGCT Poultry vaccine Animals Campylobacter Infections Campylobacter jejuni Chickens Clostridium Infections Clostridium perfringens Escherichia coli Escherichia coli Infections Poultry Diseases Vaccine Development vaccines Attenuated vaccines Combined
Substrate Utilisation and Energy Metabolism in Non-Growing Campylobacter jejuni M1cam.
Emily Stoakes, George M Savva, Ruby Coates, Noemi Tejera, Mark G Poolman, Andrew J Grant, John Wain, Dipali Singh
Sep 02, 2022
Campylobacter jejuni, the major cause of bacterial foodborne illness, is also a fastidious organism that requires strict growth requirements in the laboratory. Our aim was to study substrate utilisation and energy metabolism in...
Genome-wide fitness analyses of the foodborne pathogen Campylobacter jejuni in in vitro and in vivo models.
SPWD Vries, S Gupta, A Baig, E Wright, A Wedley, AN Jensen, LL Lora, S Humphrey, H Skovgård, K Macleod, E Pont, DP Wolanska, J L'Heureux, FM Mobegi, DGE Smith, P Everest, A Zomer, N Williams, P Wigley, T Humphrey, DJ Maskell, AJ Grant
Jun 01, 2017
PglB function and glycosylation efficiency is temperature dependent when the pgl locus is integrated in the Escherichia coli chromosome.
Vanessa S Terra, Marta Mauri, Thippeswamy H Sannasiddappa, Alexander A Smith, Mark P Stevens, Andrew J Grant, Brendan W Wren, Jon Cuccui, Glycoengineering of Veterinary Vaccines consortium (GoVV)
Feb 06, 2022
BACKGROUND: Campylobacter is an animal and zoonotic pathogen of global importance, and a pressing need exists for effective vaccines, including those that make use of conserved polysaccharide antigens. To this end, we adapted...
Analysis of Campylobacter jejuni infection in the gnotobiotic piglet and genome-wide identification of bacterial factors required for infection
SPW de Vries, A Linn, K Macleod, A MacCallum, SP Hardy, G Douce, E Watson, MP Dagleish, H Thompson, A Stevenson, D Kennedy, A Baig, C Coward, DJ Maskell, DGE Smith, AJ Grant, P Everest
Aug 17, 2017
Investigating the Campylobacter jejuni Transcriptional Response to Host Intestinal Extracts Reveals the Involvement of a Widely Conserved Iron Uptake System.
Martha M Liu, Christine J Boinett, Anson CK Chan, Julian Parkhill, Michael EP Murphy, Erin C Gaynor
Aug 29, 2019
Campylobacter jejuni is a pathogenic bacterium that causes gastroenteritis in humans yet is a widespread commensal in wild and domestic animals, particularly poultry. Using RNA sequencing, we assessed C. jejuni transcriptional...
Campylobacter jejuni RNA-seq acid resistance chicken cecal extract human fecal extract iron transport p19 streptomycin resistance Transcriptome Animals Campylobacter jejuni Cecum Chickens Complex Mixtures Culture Media Drug Resistance Bacterial Feces Gene Expression Regulation Bacterial Humans Iron Phenotype Sequence Analysis RNA Streptomycin Transcriptome
Multivalent poultry vaccine development using Protein Glycan Coupling Technology
Marta Mauri, Thippeswamy H. Sannasiddappa, Prerna Vohra, Ricardo Corona-Torres, Alexander A. Smith, Cosmin Chintoan-Uta, Abi Bremner, Vanessa S. Terra, Sherif Abouelhadid, Mark P. Stevens, Andrew J. Grant, Jon Cuccui, Brendan W. Wren
Oct 03, 2021
Abstract: Background: Poultry is the world's most popular animal-based food and global production has tripled in the past 20 years alone. Low-cost vaccines that can be combined to protect poultry against multiple infections are...
Genomic variations leading to alterations in cell morphology of $\textit{Campylobacter}$ spp
D Esson, AE Mather, E Scanlan, S Gupta, SPW de Vries, D Bailey, SR Harris, TJ McKinley, G Méric, SK Berry, P Mastroeni, SK Sheppard, G Christie, NR Thomson, J Parkhill, DJ Maskell, AJ Grant
Feb 01, 2017
Transmission and dose–response experiments for social animals
AJK Conlan, JE Line, K Hiett, C Coward, PM Van Diemen, MP Stevens, MA Jones, JR Gog, DJ Maskell
Aug 11, 2017
Application of TraDIS to define the core essential genome of Campylobacter jejuni and Campylobacter coli
Emily Stoakes, Keith Turner, Dave J Baker, Maria Suau Sans, Muhammad Yasir, Lajos Kalmar, Ruby Costigan, Martin Lott, Andrew J Grant
Apr 06, 2023