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Results: 3
Defining the origin, evolution, and immune composition of SDH-deficient renal cell carcinoma.
Joana B Neves, Kirsty Roberts, Janani Sivakumaran Nguyen, Soha El Sheikh, My-Anh Tran-Dang, Catherine Horsfield, Faiz Mumtaz, Peter Campbell, Hans Stauss, Maxine GB Tran, Thomas Mitchell
Dec 09, 2022
Succinate dehydrogenase (SDH)-deficient renal cell carcinoma represents a rare subtype of hereditary kidney cancer. Clinical diagnosis can be challenging and there is little evidence to guide systemic therapeutic options. We...
Prediction and identification of synergistic compound combinations against pancreatic cancer cells.
Yasaman KalantarMotamedi, Ran Joo Choi, Siang-Boon Koh, Jo L Bramhall, Tai-Ping Fan, Andreas Bender
Nov 22, 2021
Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations...
Immune Cell Associations with Cancer Risk.
Luis Palomero, Ivan Galván-Femenía, Rafael de Cid, Roderic Espín, Daniel R Barnes, CIMBA, Eline Blommaert, Miguel Gil-Gil, Catalina Falo, Agostina Stradella, Dan Ouchi, Albert Roso-Llorach, Concepció Violan, María Peña-Chilet, Joaquín Dopazo, Ana Isabel Extremera, Mar García-Valero, Carmen Herranz, Francesca Mateo, Elisabetta Mereu, Jonathan Beesley, Georgia Chenevix-Trench, Cecilia Roux, Tak Mak, Joan Brunet, Razq Hakem, Chiara Gorrini, Antonis C Antoniou, Conxi Lázaro, Miquel Angel Pujana
Aug 19, 2020
Proper immune system function hinders cancer development, but little is known about whether genetic variants linked to cancer risk alter immune cells. Here, we report 57 cancer risk loci associated with differences in immune...