Search
Results: 18
Calicivirus VP2 forms a portal-like assembly following receptor engagement.
Michaela J Conley, Marion McElwee, Liyana Azmi, Mads Gabrielsen, Olwyn Byron, Ian G Goodfellow, David Bhella
Feb 04, 2019
Viroplasms
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers...
Crispr-Csy4 Genome Editing Nsp2 Nsp5 liquid-liquid phase separation Protein-Rna Condensates Replication Cycle Reverse Genetics Rotavirus Viroplasm Animals Capsid Proteins Cytoplasm Cytosol Humans Phosphorylation RNA-Binding Proteins Rotavirus Rotavirus Infections Viral Nonstructural Proteins Viral Replication Compartments Virus Assembly Virus Replication
The VPS4 component of the ESCRT machinery plays an essential role in HPV infectious entry and capsid disassembly.
Justyna Broniarczyk, David Pim, Paola Massimi, Martina Bergant, Anna Goździcka-Józefiak, Colin Crump, Lawrence Banks
Aug 15, 2018
Human Papillomavirus (HPV) infection involves multiple steps, from cell attachment, through endocytic trafficking towards the trans-Golgi network, and, ultimately, the entry into the nucleus during mitosis. An essential viral...
ATPases Associated with Diverse Cellular Activities Capsid Proteins Cell Line Cells Cultured Endosomal Sorting Complexes Required for Transport Humans Papillomaviridae Papillomavirus Infections Protein Binding Protein Transport Vacuolar Proton-Translocating ATPases Viral Proteins Virus Internalization Virus Uncoating
Complete genome sequence of canine astrovirus with molecular and epidemiological characterisation of UK strains.
Canine astrovirus Complete genome Gastroenteritis Amino Acid Sequence Animals Astroviridae Astroviridae Infections Base Sequence Capsid Proteins Dog Diseases Dogs Feces Gastroenteritis Genome Viral Molecular Sequence Data Pets Polymerase Chain Reaction Sequence Analysis DNA Sequence Homology Species Specificity United Kingdom
Deep diversification of an AAV capsid protein by machine learning.
Drew H Bryant, Ali Bashir, Sam Sinai, Nina K Jain, Pierce J Ogden, Patrick F Riley, George M Church, Lucy J Colwell, Eric D Kelsic
Mar 22, 2021
Modern experimental technologies can assay large numbers of biological sequences, but engineered protein libraries rarely exceed the sequence diversity of natural protein families. Machine learning (ML) models trained directly...
Mouse Papillomavirus L1 and L2 Are Dispensable for Viral Infection and Persistence at Both Cutaneous and Mucosal Tissues.
Sarah Brendle, Jingwei J Li, Nancy M Cladel, Debra A Shearer, Lynn R Budgeon, Karla K Balogh, Hannah Atkins, Marina Costa-Fujishima, Paul Lopez, Neil D Christensen, John Doorbar, Thomas T Murooka, Jiafen Hu
Oct 29, 2021
Papillomavirus L1 and L2, the major and minor capsid proteins, play significant roles in viral assembly, entry, and propagation. In the current study, we investigate the impact of L1 and L2 on viral life cycle and tumor growth...
IHC ISH L1 mutant L2 mutant RCA RNAscope TEM mouse papillomavirus qPCR tumor growth viral copy number viral production Animals Capsid Proteins Cell Transformation Viral DNA Viral Female Genome Viral Mice Mice Nude Mucous Membrane Mutation Oncogene Proteins Viral Papillomaviridae Skin Virus Replication
Assembly of infectious enteroviruses depends on multiple, conserved genomic RNA-coat protein contacts.
Rebecca Chandler-Bostock, Carlos P Mata, Richard J Bingham, Eric C Dykeman, Bo Meng, Tobias J Tuthill, David J Rowlands, Neil A Ranson, Reidun Twarock, Peter G Stockley
Feb 08, 2021
Picornaviruses are important viral pathogens, but despite extensive study, the assembly process of their infectious virions is still incompletely understood, preventing the development of anti-viral strategies targeting this...
Co-Surveillance of Rotaviruses in Humans and Domestic Animals in Central Uganda Reveals Circulation of Wide Genotype Diversity in the Animals.
Josephine Bwogi, Charles Karamagi, Denis Karuhize Byarugaba, Phionah Tushabe, Sarah Kiguli, Prossy Namuwulya, Samuel S Malamba, Khuzwayo C Jere, Ulrich Desselberger, Miren Iturriza-Gomara
Apr 17, 2023
Rotavirus genotypes are species specific. However, interspecies transmission is reported to result in the emergence of new genotypes. A cross-sectional study of 242 households with 281 cattle, 418 goats, 438 pigs, and 258 humans...
domestic animals genotyping Rotavirus EPIDEMIOLOGY Uganda co-surveillance inter-host species transmission Feces Animals Animals Domestic Cattle Goats Swine Humans Rotavirus Infections Capsid Proteins Antigens Viral Cross-Sectional Studies Phylogeny Genotype
Published by: Viruses
Intracellular neutralisation of rotavirus by VP6-specific IgG.
Sarah L Caddy, Marina Vaysburd, Mark Wing, Stian Foss, Jan Terje Andersen, Kevin O'Connell, Keith Mayes, Katie Higginson, Miren Iturriza-Gómara, Ulrich Desselberger, Leo C James
Aug 11, 2020
Rotavirus is a major cause of gastroenteritis in children, with infection typically inducing high levels of protective antibodies. Antibodies targeting the middle capsid protein VP6 are particularly abundant, and as VP6 is only...
Discovery of several thousand highly diverse circular DNA viruses.
Michael J Tisza, Diana V Pastrana, Nicole L Welch, Brittany Stewart, Alberto Peretti, Gabriel J Starrett, Yuk-Ying S Pang, Siddharth R Krishnamurthy, Patricia A Pesavento, David H McDermott, Philip M Murphy, Jessica L Whited, Bess Miller, Jason Brenchley, Stephan P Rosshart, Barbara Rehermann, John Doorbar, Blake A Ta'ala, Olga Pletnikova, Juan C Troncoso, Susan M Resnick, Ben Bolduc, Matthew B Sullivan, Arvind Varsani, Anca M Segall, Christopher B Buck
Mar 06, 2020
Although millions of distinct virus species likely exist, only approximately 9000 are catalogued in GenBank's RefSeq database. We selectively enriched for the genomes of circular DNA viruses in over 70 animal samples, ranging...
Co-Surveillance of Rotaviruses in Humans and Domestic Animals in Central Uganda Reveals Circulation of Wide Genotype Diversity in the Animals.
Josephine Bwogi, Charles Karamagi, Denis Karuhize Byarugaba, Phionah Tushabe, Sarah Kiguli, Prossy Namuwulya, Samuel S Malamba, Khuzwayo C Jere, Ulrich Desselberger, Miren Iturriza-Gomara
Apr 05, 2023
Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.
Nejc Kejzar, Elina Laanto, Ilona Rissanen, Vahid Abrishami, Muniyandi Selvaraj, Sylvain Moineau, Janne Ravantti, Lotta-Riina Sundberg, Juha T Huiskonen
Jan 04, 2023
The origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate...
The architecture and stabilisation of flagellotropic tailed bacteriophages.
Joshua M Hardy, Rhys A Dunstan, Rhys Grinter, Matthew J Belousoff, Jiawei Wang, Derek Pickard, Hariprasad Venugopal, Gordon Dougan, Trevor Lithgow, Fasséli Coulibaly
Sep 21, 2020
Flagellotropic bacteriophages engage flagella to reach the bacterial surface as an effective means to increase the capture radius for predation. Structural details of these viruses are of great interest given the substantial...
Induction of antibody responses to African horse sickness virus (AHSV) in ponies after vaccination with recombinant modified vaccinia Ankara (MVA).
Rachael Chiam, Emma Sharp, Sushila Maan, Shujing Rao, Peter Mertens, Barbara Blacklaws, Nick Davis-Poynter, James Wood, Javier Castillo-Olivares
Mar 13, 2020
BACKGROUND: African horse sickness virus (AHSV) causes a non-contagious, infectious disease in equids, with mortality rates that can exceed 90% in susceptible horse populations. AHSV vaccines play a crucial role in the control...
Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections.
Neneh Sallah, Wendell Miley, Nazzarena Labo, Tommy Carstensen, Segun Fatumo, Deepti Gurdasani, Martin O Pollard, Alexander T Dilthey, Alexander J Mentzer, Vickie Marshall, Elena M Cornejo Castro, Cristina Pomilla, Elizabeth H Young, Gershim Asiki, Martin L Hibberd, Manjinder Sandhu, Paul Kellam, Robert Newton, Denise Whitby, Inês Barroso
Oct 02, 2020
Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV) establish life-long infections and are associated with malignancies. Striking geographic variation in incidence and the fact that virus alone is...
Adolescent Adult Antibodies Viral Antigens Viral Capsid Proteins Coinfection Disease Resistance Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Female Gene Expression Genome-Wide Association Study HIV HLA-DQ alpha-Chains Henipavirus Infections Herpesvirus 4 Human Herpesvirus 8 Human Host-Pathogen Interactions Humans Incidence Male Middle Aged Rural Population Sarcoma Kaposi Uganda Urban Population
A barnavirus sequence mined from a transcriptome of the Antarctic pearlwort Colobanthus quitensis.
Max L Nibert, Austin R Manny, Humberto J Debat, Andrew E Firth, Laura Bertini, Carla Caruso
May 16, 2018
Because so few viruses in the family Barnaviridae have been reported, we searched for more of them in public sequence databases. Here, we report the complete coding sequence of Colobanthus quitensis associated barnavirus 1...