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Imaging as a surrogate marker of drug efficacy in cardiovascular disease.
Many cardiovascular drugs in the pipeline will fail to demonstrate a clear clinical benefit when evaluated in large-scale clinical outcome trials; which are costly, require lengthy follow-up, and can potentially expose patients...
Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).
Nina S McCarthy, Ciara Vangjeli, Praveen Surendran, Achim Treumann, Cathy Rooney, Emily Ho, Peter Sever, Simon Thom, Alun D Hughes, Patricia B Munroe, Philip Howard, Toby Johnson, Mark Caulfield, Denis C Shields, Eoin O'Brien, Desmond J Fitzgerald, Alice V Stanton
Mar 16, 2018
BACKGROUND AND AIMS: Elevated urinary 11-dehydro thromboxane B2 (TxB2), a measure of thromboxane A2 formation in vivo, predicts future atherothrombotic events. To further understand this relationship, the genetic determinants of...
Genome wide association study Thrombosis Thromboxane Aged Aspirin Cardiovascular Agents Cardiovascular Diseases Carrier Proteins Contactins Europe Female Gene Frequency Genetic Markers Genetic Predisposition to Disease Genome-Wide Association Study Haplotypes Humans Incidence Male Middle Aged Multicenter Studies as Topic Phenotype Polymorphism Single Nucleotide Primary Prevention Progression-Free Survival RNA-Binding Proteins Randomized Controlled Trials as Topic Risk Factors Thromboxane A2 Thromboxane B2 Time Factors White People
RApid Primary care Initiation of Drug treatment for Transient Ischaemic Attack (RAPID-TIA)
Duncan Edwards, Kate Fletcher, Rachel Deller, Richard McManus, Daniel Lasserson, Matthew Giles, Don Sims, John Norrie, Graham McGuire, Simon Cohn, Fiona Whittle, Vikki Hobbs, Christopher Weir, Jonathan Mant
Jul 17, 2013
Antihypertensive Agents Aspirin Cardiovascular Agents Clinical Protocols Dipyridamole Drug Administration Schedule Drug Therapy Combination Emergency Service hospital England Feasibility Studies General Practice Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Ischemic Attack Transient Pilot Projects Primary Health Care Referral and Consultation Research Design Secondary Prevention Simvastatin Time Factors Treatment Outcome
Patients' views about taking a polypill to manage cardiovascular risk
blood pressure cardiovascular disease Cholesterol patients’ views polypill Prevention PRIMARY CARE Risk Factors Aged Attitude to Health Cardiovascular Agents Cardiovascular Diseases Drug Combinations Drug Monitoring Female Follow-Up Studies Humans Male Middle Aged Monitoring Physiologic Morbidity Primary Health Care qualitative research Risk Factors United Kingdom
Opinions on the use of technology to improve tablet taking in >65-year-old patients on cardiovascular medications.
Objective This study was performed to evaluate the perceptions of the use of technology to improve cardiovascular medicine taking among patients aged >65 years. Methods This qualitative study used focus groups with people aged...
>65 years old Adherence cardiovascular medications digital interventions focus group technology Aged Attitude to Health Biomedical Technology Cardiovascular Agents Cardiovascular Diseases Computers Handheld Female Focus Groups Health Knowledge Attitudes practice Humans Male Medication Adherence qualitative research Reminder Systems Tablets technology Pharmaceutical
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
Min Park, Takanori Nishimura, Carlos D Baeza-Garza, Stuart T Caldwell, Pamela Boon Li Pun, Hiran A Prag, Tim Young, Olga Sauchanka, Angela Logan, Marleen Forkink, Anja V Gruszczyk, Tracy A Prime, Sabine Arndt, Alba Naudi, Reinald Pamplona, Melinda T Coughlan, Mitchel Tate, Rebecca H Ritchie, Federico Caicci, Nina Kaludercic, Fabio Di Lisa, Robin AJ Smith, Richard C Hartley, Michael P Murphy, Thomas Krieg
Sep 29, 2020
Advanced glycation endproducts (AGE) Akita mice Diabetes Heart failure with preserved ejection fraction (HFpEF) Mitochondria Animals Benzamides Cardiovascular Agents Diabetic Cardiomyopathies Disease Models Animal Glycation End Products Advanced Heart Failure Male Mice Inbred C57BL Mice Mutant Strains Mitochondria Heart Stroke Volume Ventricular Dysfunction Left Ventricular Function Left
Succinate metabolism
Myocardial ischaemia/reperfusion (IR) injury is a major cause of death worldwide and remains a disease for which current clinical therapies are strikingly deficient. While the production of mitochondrial reactive oxygen species...
Ischaemia/reperfusion Mitochondria Reactive Oxygen Species Succinate Animals Cardiovascular Agents Electron Transport Electron Transport Complex I Electron Transport Complex II Energy Metabolism Humans Myocardial Reperfusion Injury Myocardium Reactive Oxygen Species Signal Transduction Succinic Acid
Stroke survivors', caregivers' and GPs' attitudes towards a polypill for the secondary prevention of stroke
cGMP at the centre of attention
The nitric oxide (NO)-protein kinase G (PKG) pathway has been known for some time to be an important target for cardioprotection against ischaemia/reperfusion injury and heart failure. While many approaches for reducing infarct...
Cost-effectiveness analysis of use of a polypill versus usual care or best practice for primary prevention in people at high risk of cardiovascular disease
Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis.
Kaisa M Mäki-Petäjä, Lisa Day, Joseph Cheriyan, Frances C Hall, Andrew JK Östör, Nicholas Shenker, Ian B Wilkinson
Dec 18, 2015
arteriosclerosis endothelial function Inflammation rheumatoid arthritis tetrahydrobiopterin Administration Oral Adult Aged Arthritis Rheumatoid Biomarkers Biopterin Cardiovascular Agents Cross-Over Studies Dietary Supplements Double-Blind Method Drug Administration Schedule Endothelium Vascular England Female Humans Inflammation Mediators Male Middle Aged Nitric Oxide Synthase Type III Pilot Projects Pulse Wave Analysis Time Factors Treatment Outcome Vascular diseases Vascular Stiffness Vasodilation Young Adult