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Proteomics-based metabolic modeling reveals that fatty acid oxidation (FAO) controls endothelial cell (EC) permeability.
Francesca Patella, Zachary T Schug, Erez Persi, Lisa J Neilson, Zahra Erami, Daniele Avanzato, Federica Maione, Juan R Hernandez-Fernaud, Gillian Mackay, Liang Zheng, Steven Reid, Christian Frezza, Enrico Giraudo, Alessandra Fiorio Pla, Kurt Anderson, Eytan Ruppin, Eyal Gottlieb, Sara Zanivan
Feb 05, 2020
Endothelial cells (ECs) play a key role to maintain the functionality of blood vessels. Altered EC permeability causes severe impairment in vessel stability and is a hallmark of pathologies such as cancer and thrombosis....