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CP: Immunology Gram-negative IRAK LPS NF-kB TLR TRAF6 Toll-like receptor Cell Signaling innate immunity macrophage Adaptor Proteins Signal Transducing Adaptor Proteins Vesicular Transport Humans Interleukin-1 Receptor-Associated Kinases Myeloid Differentiation Factor 88 Signal Transduction Toll-Like Receptor 3 Toll-Like Receptor 4

Ral Ras Autophagy Cell Signaling peptide chemical synthesis Peptides Protein-Protein Interaction small GTPase stapled peptides therapeutics Cell Line Humans Isoenzymes Neoplasms Peptides Phosphatidylinositol 3-Kinases Signal Transduction ral GTP-Binding Proteins ras Proteins

T cell Cell Signaling cluster of differentiation 4 (CD4) immunology non-receptor tyrosine kinase (nRTK) protein phosphorylation sterile α motif (SAM) Adaptor Proteins Signal Transducing Amino Acid Motifs Amino Acid Substitution Animals Humans Jurkat Cells Lymphocyte Activation Mice Mutation Missense Phosphoproteins Phosphorylation Protein Domains Protein-Tyrosine Kinases Receptors Antigen T-Cell T-Lymphocytes Tyrosine

Human cytomegalovirus (HCMV) latency and reactivation rely on a complex interplay between cellular differentiation, cell signaling pathways, and viral gene functions. HCMV reactivation in dendritic cells (DCs) is triggered by...

Cell Signaling chromatin modification cytomegalovirus reactivation epigenetic regulation Gene Expression hematopoietic cell kinase herpesvirus histone acetylation lysine acetyltransferase 6A (KAT6A) Phosphoproteomics Cells Cultured Cytomegalovirus Histone Acetyltransferases Humans Promoter Regions Genetic Virus Activation Zinc Fingers src-Family Kinases

Recent technological developments allow us to measure the status of dozens of proteins in individual cells. This opens the way to understand the heterogeneity of complex multi-signaling networks across cells and cell types, with...

Cell Signaling Crowdsourcing mass cytometry predictive modeling single cell

Cdc42 GTPase Kras (KRAS) biologics Cancer cancer therapeutics cell migration Cell Proliferation Cell Signaling cyclic peptide Drug Discovery Nuclear Magnetic Resonance (NMR) peptide conformation Binding Sites Cell Movement Cell Proliferation Cell-Penetrating Peptides Drug Discovery GTP Phosphohydrolases Humans Molecular Structure Neoplasm Invasiveness Neoplasms Peptides Cyclic Signal Transduction cdc42 GTP-Binding Protein ras Proteins

Cell Signaling FGFR MET receptor Signal to noise Transmembrane receptors Cell Membrane Protein Multimerization Proto-Oncogene Proteins c-met Receptors Fibroblast Growth Factor Signal Transduction

Abstract: T cells discriminate between healthy and infected cells with remarkable sensitivity when mounting an immune response, which is hypothesized to depend on T cells combining stimuli from multiple antigen‐presenting cell...

EMBO41 EMBO19 EMBO37 article ARTICLES Cell Signaling optogenetics Receptors T cells Transcription Factors

Much research has focused on the PI3-kinase and PTEN signaling pathway with the aim to stimulate repair of the injured central nervous system. Axons in the central nervous system fail to regenerate, meaning that injuries or...

PI3-kinase PI3K PTEN axon cytoskeleton Axon regeneration axon transport Cell Signaling Central Nervous System growth cone Neuroprotection trafficking Transcription Translation

G protein-coupled receptor Saccharomyces cerevisiae Biosensor Cell Signaling cell-to-cell communication genome engineering synthetic biology Gene Expression Genetic Engineering Humans Pheromones Receptors G-Protein-Coupled Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Signal Transduction Transcription Factors

Wiskott-Aldrich syndrome protein (WASP) activates the actin-related protein 2/3 homolog (Arp2/3) complex and regulates actin polymerization in a physiological setting. Cell division cycle 42 (Cdc42) is a key activator of WASP...

Cdc42 Cell Signaling Cytoskeleton Intrinsically Disordered Protein Protein Conformation protein motif protein–protein interaction small GTPase structure–function Thermodynamics Actins Amino Acid Sequence Animals Binding Sites Crystallography X-Ray Humans Kinetics Neoplasms Protein Binding Regulatory Sequences Nucleic Acid Signal Transduction Wiskott-Aldrich Syndrome Wiskott-Aldrich Syndrome Protein cdc42 GTP-Binding Protein ras Proteins

Bone Morphogenetic Protein (BMP) Cell Signaling Crystal structure Disulfide Endothelial Cell Redox Regulation Animals Cell Line Crystallization Crystallography X-Ray DNA Complementary Dimerization Disulfides Endothelial Cells Gene Expression Regulation Growth Differentiation Factor 2 Growth Differentiation Factors Humans Ligands Mice Oxidation-Reduction Phenotype Proteolysis Recombinant Proteins Signal Transduction

BioModelAnalyzer (BMA) is an open-source graphical tool for the development of executable models of protein and gene networks within cells. Based upon the Qualitative Networks formalism, the user can rapidly construct large...

Cell Signaling executable models formal verification Systems Biology Cell Cycle Cyclic AMP Dictyostelium Germ Cells Models Biological Models Molecular Signal Transduction Software

Ral GTPases have been implicated as critical drivers of cell growth and metastasis in numerous Ras-driven cancers. We have previously reported stapled peptides, based on the Ral effector RLIP76, that can disrupt Ral signaling....

GTPase K-Ras RLIP76 Ral Cancer Cell Signaling chemical biology Drug Discovery Protein-Protein Interaction stapled peptides ATP-Binding Cassette Transporters Calorimetry Circular dichroism Fluorescence GTPase-Activating Proteins Humans Magnetic Resonance Spectroscopy Protein Binding Signal Transduction ral GTP-Binding Proteins

T cells discriminate between healthy and infected cells with remarkable sensitivity when mounting an immune response, which is hypothesized to depend on T cells combining stimuli from multiple antigen-presenting cell...

T cells Cell Signaling optogenetics Receptors Transcription Factors Calcium Cell Line HEK293 Cells Humans Jurkat Cells Lymphocyte Activation optogenetics Protein Engineering Receptors Antigen T-Cell Receptors Chimeric Antigen Signal Transduction T-Lymphocytes

Clear cell renal cell carcinoma (ccRCC) contains cancer stem-like cells (CSCs) that express CD133 (ccRCC-CD133+). CSCs are rarely in cell cycle and, as nonproliferating cells, resist most chemotherapeutic agents. Previously, we...

R1TNF R2TNF STAT3 ccRCC Cell Signaling