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The Autonomic Nervous System Pulls the Strings to Coordinate Circadian HSC Functions.
As for many other adult stem cells, the behavior of hematopoietic stem and progenitor cells (HSPCs) is subjected to circadian regulatory patterns. Multiple HSPC functions, such as proliferation, differentiation or trafficking...
adrenergic Autonomic Nervous System cholinergic Circadian hematopoietic (stem) cells Adrenergic Neurons Animals Autonomic Nervous System Bone Marrow Cell Differentiation Cell Proliferation Cholinergic Neurons Circadian Rhythm Gene Expression Regulation Hematopoietic Stem Cells Humans Periodicity Signal Transduction Stem Cell Niche Suprachiasmatic Nucleus Time Factors
Regulation of coordinated muscular relaxation in Drosophila larvae by a pattern-regulating intersegmental circuit.
Atsuki Hiramoto, Julius Jonaitis, Sawako Niki, Hiroshi Kohsaka, Richard D Fetter, Albert Cardona, Stefan R Pulver, Akinao Nose
Jun 21, 2021
The functional role of sequentially neuromodulated synaptic plasticity in behavioural learning.
Grace Wan Yu Ang, Clara S Tang, Y Audrey Hay, Sara Zannone, Ole Paulsen, Claudia Clopath
Jul 26, 2021
To survive, animals have to quickly modify their behaviour when the reward changes. The internal representations responsible for this are updated through synaptic weight changes, mediated by certain neuromodulators conveying...
Acetylcholine-modulated plasticity in reward-driven navigation
Neuromodulation plays a fundamental role in the acquisition of new behaviours. In previous experimental work, we showed that acetylcholine biases hippocampal synaptic plasticity towards depression, and the subsequent application...
Tumor Necrosis Factor α Influences Phenotypic Plasticity and Promotes Epigenetic Changes in Human Basal Forebrain Cholinergic Neuroblasts.
Giulia Guarnieri, Erica Sarchielli, Paolo Comeglio, Erika Herrera-Puerta, Irene Piaceri, Benedetta Nacmias, Matteo Benelli, Gavin Kelsey, Mario Maggi, Pasquale Gallina, Gabriella Barbara Vannelli, Annamaria Morelli
Nov 09, 2020
TNFα is the main proinflammatory cytokine implicated in the pathogenesis of neurodegenerative disorders, but it also modulates physiological functions in both the developing and adult brain. In this study, we investigated a...
Alzheimer’s disease DNA Methylation NGF TNFα receptors ciliogenesis human fetal neurons Neurogenesis Neuroinflammation Nucleus basalis of Meynert Basal Forebrain basal nucleus of Meynert Cell Line Cholinergic Neurons DNA Methylation Epigenesis Genetic Humans Microtubule-Associated Proteins Nerve Tissue Proteins Neuronal Plasticity Receptors Nerve Growth Factor Receptors Tumor Necrosis Factor Type II Tumor Necrosis Factor-alpha whole genome sequencing
Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location.
The hippocampus plays a central role in long-term memory formation, and different hippocampal network states are thought to have different functions in this process. These network states are controlled by neuromodulatory inputs...
Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.
Synucleinopathies, characterized by intracellular aggregation of α-synuclein protein, share a number of features in pathology and disease progression. However, the vulnerable cell population differs significantly between the...
Animals Animals Newborn Axons Cell Nucleus Cholinergic Neurons Dependovirus Disease Models Animal Disease Progression Dopamine Agonists Exploratory Behavior Female Genetic Vectors Humans Interneurons Lewy Body Disease Microglia Motor Activity Neostriatum Phenotype Pregnancy Prosencephalon Protein Transport Rats Rats Sprague-Dawley Synapses ALPHA-SYNUCLEIN