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Psychiatric disorders in children with 16p11.2 deletion and duplication.

Maria Niarchou, Samuel JRA Chawner, Joanne L Doherty, Anne M Maillard, Sébastien Jacquemont, Wendy K Chung, LeeAnne Green-Snyder, Raphael A Bernier, Robin P Goin-Kochel, Ellen Hanson, David EJ Linden, Stefanie C Linden, F Lucy Raymond, David Skuse, Jeremy Hall, Michael J Owen, Marianne BM van den Bree

Feb 18, 2019

Deletion and duplication of 16p11.2 (BP4-BP5) have been associated with an increased risk of intellectual disability and psychiatric disorder. This is the first study to compare the frequency of a broad spectrum of psychiatric...

Adolescent Attention Deficit Disorder with Hyperactivity Autism spectrum disorder Case-Control Studies Child Child Preschool Chromosome Duplication Chromosomes Human Pair 16 DNA Copy Number Variations Female Heterozygote Humans Male Sequence Deletion

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Chromosome engineering in zygotes with CRISPR/Cas9.

Katharina Boroviak, Brendan Doe, Ruby Banerjee, Fengtang Yang, Allan Bradley

Oct 14, 2020

Deletions, duplications, and inversions of large genomic regions covering several genes are an important class of disease causing variants in humans. Modeling these structural variants in mice requires multistep processes in ES...

CRISPR/Cas9 large structural variants zygote injection Animals Base Sequence CRISPR-Cas Systems Chromosome Duplication Chromosome Inversion Chromosomes DNA Feasibility Studies Female Genetic Engineering Male Mice Mice Inbred C57BL Molecular Sequence Data

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