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Results: 69
Interhomolog polymorphism shapes meiotic crossover within the Arabidopsis RAC1 and RPP13 disease resistance genes.
Heïdi Serra, Kyuha Choi, Xiaohui Zhao, Alexander R Blackwell, Juhyun Kim, Ian R Henderson
Jan 02, 2019
Whole-chromosome hitchhiking driven by a male-killing endosymbiont.
Simon H Martin, Kumar Saurabh Singh, Ian J Gordon, Kennedy Saitoti Omufwoko, Steve Collins, Ian A Warren, Hannah Munby, Oskar Brattström, Walther Traut, Dino J Martins, David AS Smith, Chris D Jiggins, Chris Bass, Richard H ffrench-Constant
Apr 14, 2020
Neo-sex chromosomes are found in many taxa, but the forces driving their emergence and spread are poorly understood. The female-specific neo-W chromosome of the African monarch (or queen) butterfly Danaus chrysippus presents an...
New Data on Comparative Cytogenetics of the Mouse-Like Hamsters (Calomyscus Thomas, 1905) from Iran and Turkmenistan.
Svetlana A Romanenko, Vladimir G Malikov, Ahmad Mahmoudi, Feodor N Golenishchev, Natalya A Lemskaya, Jorge C Pereira, Vladimir A Trifonov, Natalia A Serdyukova, Malcolm A Ferguson-Smith, Mansour Aliabadian, Alexander S Graphodatsky
Sep 13, 2021
The taxonomy of the genus Calomyscus remains controversial. According to the latest systematics the genus includes eight species with great karyotypic variation. Here, we studied karyotypes of 14 Calomyscus individuals from...
banding Chromosome Painting fluorescent in situ hybridization Karyotype Molecular cytogenetics painting probes type locality Animals Chromosome Banding Chromosomes Mammalian Cricetinae Cytogenetic Analysis evolution Molecular Heterochromatin In Situ Hybridization Fluorescence Iran Karyotype Mice Phylogeography Species Specificity Synteny Turkmenistan
Genetic determinants of survival in progressive supranuclear palsy
Edwin Jabbari, Shunsuke Koga, Rebecca R Valentino, Regina H Reynolds, Raffaele Ferrari, Manuela MX Tan, James B Rowe, Clifton L Dalgard, Sonja W Scholz, Dennis W Dickson, Thomas T Warner, Tamas Revesz, Günter U Höglinger, Owen A Ross, Mina Ryten, John Hardy, Maryam Shoai, Huw R Morris, PSP Genetics Group
Jan 21, 2021
BACKGROUND: The genetic basis of variation in the progression of primary tauopathies has not been determined. We aimed to identify genetic determinants of survival in progressive supranuclear palsy (PSP). METHODS: In stage one...
Adult Age of Onset Aged Chromosomes Human Pair 12 Databases Genetic Female Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Humans Kaplan-Meier Estimate Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Linkage Disequilibrium Male Middle Aged Polymorphism Single Nucleotide RNA Long Noncoding Supranuclear Palsy Progressive Survival Analysis White People
Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development.
Abra G Brisbin, Yan W Asmann, Honglin Song, Ya-Yu Tsai, Jeremiah A Aakre, Ping Yang, Robert B Jenkins, Paul Pharoah, Fredrick Schumacher, David V Conti, David J Duggan, Mark Jenkins, John Hopper, Steven Gallinger, Polly Newcomb, Graham Casey, Thomas A Sellers, Brooke L Fridley
Feb 23, 2012
Mobilization of Pack-CACTA transposons in Arabidopsis suggests the mechanism of gene shuffling.
Pack-TYPE transposons are a unique class of potentially mobile non-autonomous elements that can capture, merge and relocate fragments of chromosomal DNA. It has been postulated that their activity accelerates the evolution of...
Lambda Red recombinase-mediated integration of the high molecular weight DNA into the Escherichia coli chromosome.
DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis.
Nataliya E Yelina, Christophe Lambing, Thomas J Hardcastle, Xiaohui Zhao, Bruno Santos, Ian R Henderson
Nov 13, 2015
Integrative bacterial artificial chromosomes for DNA integration into the Bacillus subtilis chromosome.
Bacterial artificial chromosome Chromosomal integration RecA homologous recombination mVenus λ red recombineering Bacillus subtilis Chromosomes Artificial Bacterial Chromosomes Bacterial Escherichia coli Genetic Engineering Plasmids Rec A Recombinases Recombination Genetic synthetic biology Transformation Bacterial
Major Improvements to the Heliconius melpomene Genome Assembly Used to Confirm 10 Chromosome Fusion Events in 6 Million Years of Butterfly Evolution.
John W Davey, Mathieu Chouteau, Sarah L Barker, Luana Maroja, Simon W Baxter, Fraser Simpson, Richard M Merrill, Mathieu Joron, James Mallet, Kanchon K Dasmahapatra, Chris D Jiggins
Jan 27, 2016
Eueides Heliconius chromosome fusions genome assembly linkage mapping Animals Butterflies Chromosome Mapping Chromosomes Insect Computational Biology evolution Molecular Female Genetic Linkage Genetic Loci Genome Size Genome Insect Genomics Haplotypes High-Throughput Nucleotide Sequencing hybridization Genetic Male Molecular Sequence Annotation Polymorphism Single Nucleotide
Recombination rate variation shapes barriers to introgression across butterfly genomes.
Hybridisation and introgression can dramatically alter the relationships among groups of species, leading to phylogenetic discordance across the genome and between populations. Introgression can also erode species differences...
Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants.
In model organisms, RNA-sequencing (RNA-seq) is frequently used to assess the effect of genetic mutations on cellular and developmental processes. Typically, animals heterozygous for a mutation are crossed to produce offspring...
Effects of Gene Dose, Chromatin, and Network Topology on Expression in Drosophila melanogaster.
Hangnoh Lee, Dong-Yeon Cho, Cale Whitworth, Robert Eisman, Melissa Phelps, John Roote, Thomas Kaufman, Kevin Cook, Steven Russell, Teresa Przytycka, Brian Oliver
Nov 20, 2017
Deletions, commonly referred to as deficiencies by Drosophila geneticists, are valuable tools for mapping genes and for genetic pathway discovery via dose-dependent suppressor and enhancer screens. More recently, it has become...
Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes.
Naomi J Petela, Andres Gonzalez Llamazares, Sarah Dixon, Bin Hu, Byung-Gil Lee, Jean Metson, Heekyo Seo, Antonio Ferrer-Harding, Menelaos Voulgaris, Thomas Gligoris, James Collier, Byung-Ha Oh, Jan Löwe, Kim A Nasmyth
Jul 28, 2021
Cohesin's association with and translocation along chromosomal DNAs depend on an ATP hydrolysis cycle driving the association and subsequent release of DNA. This involves DNA being 'clamped' by Scc2 and ATP-dependent engagement...
S. cerevisiae Chromosomes cryo-EM Folding Gene Expression molecular biophysics sister chromatid cohesion structural biology Adenosine Triphosphatases Cell Cycle Proteins Chromatids Chromosomal Proteins Non-Histone Chromosomes Cryoelectron Microscopy DNA Dimerization Gene Expression Regulation Fungal Hydrolysis Protein Domains Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins
Qiaoli Li, Annerose Berndt, Beth A Sundberg, Kathleen A Silva, Victoria E Kennedy, Clinton L Cario, Matthew A Richardson, Thomas H Chase, Paul N Schofield, Jouni Uitto, John P Sundberg
May 09, 2016
Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus.
Melissa A Buckley, Nicholas T Woods, Jonathan P Tyrer, Gustavo Mendoza-Fandiño, Kate Lawrenson, Dennis J Hazelett, Hamed S Najafabadi, Anxhela Gjyshi, Renato S Carvalho, Paulo C Lyra, Simon G Coetzee, Howard C Shen, Ally W Yang, Madalene A Earp, Sean J Yoder, Harvey Risch, Georgia Chenevix-Trench, Susan J Ramus, Catherine M Phelan, Gerhard A Coetzee, Houtan Noushmehr, Timothy R Hughes, Thomas A Sellers, Ellen L Goode, Paul D Pharoah, Simon A Gayther, Alvaro NA Monteiro, Ovarian Cancer Association Consortium
Dec 18, 2018
Genome-wide association studies have identified 40 ovarian cancer risk loci. However, the mechanisms underlying these associations remain elusive. In this study, we conducted a two-pronged approach to identify candidate causal...
Base Sequence Carcinoma Ovarian Epithelial Cell Cycle Proteins Cell Line Tumor Chromosome Mapping Chromosomes Human Pair 9 Cystadenocarcinoma Serous DNA Neoplasm DNA-Binding Proteins Female Genetic Predisposition to Disease Genome-Wide Association Study HEK293 Cells Humans Linkage Disequilibrium Ovarian Neoplasms Polymorphism Single Nucleotide
Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved.
DNA methylation is a repressive epigenetic modification that covers vertebrate genomes. Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often associated with gene promoters and play central...
Animals Cell Line Chromosomes Human Pair 21 Conserved Sequence CpG Islands DNA DNA Methylation evolution Molecular Female Gene Expression Regulation Humans Male Mice Inbred C57BL Mice Transgenic Promoter Regions Genetic Protein Binding Repetitive Sequences Nucleic Acid Species Specificity Transcription Factors Vertebrates
Genetic dissection of assortative mating behavior.
Richard M Merrill, Pasi Rastas, Simon H Martin, Maria C Melo, Sarah Barker, John Davey, W Owen McMillan, Chris D Jiggins
Mar 19, 2019
The evolution of new species is made easier when traits under divergent ecological selection are also mating cues. Such ecological mating cues are now considered more common than previously thought, but we still know little...
Imprinting methylation in SNRPN and MEST1 in adult blood predicts cognitive ability.
Marlene Lorgen-Ritchie, Alison D Murray, Anne C Ferguson-Smith, Marcus Richards, Graham W Horgan, Louise H Phillips, Gwen Hoad, Ishbel Gall, Kristina Harrison, Geraldine McNeill, Mitsuteru Ito, Paul Haggarty
May 01, 2019
Genomic imprinting is important for normal brain development and aberrant imprinting has been associated with impaired cognition. We studied the imprinting status in selected imprints (H19, IGF2, SNRPN, PEG3, MEST1, NESPAS...
EMQN best practice guidelines for the molecular genetic testing and reporting of chromosome 11p15 imprinting disorders
Katja Eggermann, Jet Bliek, Frédéric Brioude, Elizabeth Algar, Karin Buiting, Silvia Russo, Zeynep Tümer, David Monk, Gudrun Moore, Thalia Antoniadi, Fiona MacDonald, Irène Netchine, Paolo Lombardi, Lukas Soellner, Matthias Begemann, Dirk Prawitt, Eamonn R Maher, Marcel Mannens, Andrea Riccio, Rosanna Weksberg, Pablo Lapunzina, Karen Grønskov, Deborah JG Mackay, Thomas Eggermann
Apr 13, 2016
PglB function and glycosylation efficiency is temperature dependent when the pgl locus is integrated in the Escherichia coli chromosome.
Vanessa S Terra, Marta Mauri, Thippeswamy H Sannasiddappa, Alexander A Smith, Mark P Stevens, Andrew J Grant, Brendan W Wren, Jon Cuccui, Glycoengineering of Veterinary Vaccines consortium (GoVV)
Feb 06, 2022
BACKGROUND: Campylobacter is an animal and zoonotic pathogen of global importance, and a pressing need exists for effective vaccines, including those that make use of conserved polysaccharide antigens. To this end, we adapted...
Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1.
Bianca Jupp, Silvia Pitzoi, Enrico Petretto, Adam C Mar, Yolanda Pena Oliver, Emily R Jordan, Stephanie Taylor, Santosh S Atanur, Prashant K Srivastava, Kathrin Saar, Norbert Hubner, Wolfgang H Sommer, Oliver Staehlin, Rainer Spanagel, Emma S Robinson, Gunter Schumann, Margarita Moreno, Barry J Everitt, Trevor W Robbins, Timothy J Aitman, Jeffrey W Dalley
Apr 02, 2020
Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.
Marilyn B Renfree, Anthony T Papenfuss, Janine E Deakin, James Lindsay, Thomas Heider, Katherine Belov, Willem Rens, Paul D Waters, Elizabeth A Pharo, Geoff Shaw, Emily SW Wong, Christophe M Lefèvre, Kevin R Nicholas, Yoko Kuroki, Matthew J Wakefield, Kyall R Zenger, Chenwei Wang, Malcolm Ferguson-Smith, Frank W Nicholas, Danielle Hickford, Hongshi Yu, Kirsty R Short, Hannah V Siddle, Stephen R Frankenberg, Keng Yih Chew, Brandon R Menzies, Jessica M Stringer, Shunsuke Suzuki, Timothy A Hore, Margaret L Delbridge, Hardip R Patel, Amir Mohammadi, Nanette Y Schneider, Yanqiu Hu, William O'Hara, Shafagh Al Nadaf, Chen Wu, Zhi-Ping Feng, Benjamin G Cocks, Jianghui Wang, Paul Flicek, Stephen MJ Searle, Susan Fairley, Kathryn Beal, Javier Herrero, Dawn M Carone, Yutaka Suzuki, Sumio Sugano, Atsushi Toyoda, Yoshiyuki Sakaki, Shinji Kondo, Yuichiro Nishida, Shoji Tatsumoto, Ion Mandiou, Arthur Hsu, Kaighin A McColl, Benjamin Lansdell, George Weinstock, Elizabeth Kuczek, Annette McGrath, Peter Wilson, Artem Men, Mehlika Hazar-Rethinam, Allison Hall, John Davis, David Wood, Sarah Williams, Yogi Sundaravadanam, Donna M Muzny, Shalini N Jhangiani, Lora R Lewis, Margaret B Morgan, Geoffrey O Okwuonu, San Juana Ruiz, Jireh Santibanez, Lynne Nazareth, Andrew Cree, Gerald Fowler, Christie L Kovar, Huyen H Dinh, Vandita Joshi, Chyn Jing, Fremiet Lara, Rebecca Thornton, Lei Chen, Jixin Deng, Yue Liu, Joshua Y Shen, Xing-Zhi Song, Janette Edson, Carmen Troon, Daniel Thomas, Amber Stephens, Lankesha Yapa, Tanya Levchenko, Richard A Gibbs, Desmond W Cooper, Terence P Speed, Asao Fujiyama, Jennifer AM Graves, Rachel J O'Neill, Andrew J Pask, Susan M Forrest, Kim C Worley
Mar 30, 2012
BACKGROUND: We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced....
A genomic Neolithic time transect of hunter-farmer admixture in central Poland.
DM Fernandes, D Strapagiel, P Borówka, B Marciniak, E Żądzińska, K Sirak, V Siska, R Grygiel, J Carlsson, A Manica, W Lorkiewicz, R Pinhasi
Feb 07, 2019
Ancient DNA genome-wide analyses of Neolithic individuals from central and southern Europe indicate an overall population turnover pattern in which migrating farmers from Anatolia and the Near East largely replaced autochthonous...
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