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Long-Term Costs and Health Consequences of Issuing Shorter Duration Prescriptions for Patients with Chronic Health Conditions in the English NHS.
BACKGROUND: The National Health Service (NHS) in England spends over £9 billion on prescription medicines dispensed in primary care, of which over two-thirds is accounted for by repeat prescriptions. Recently, GPs in England...
Clinical effectiveness and cost-effectiveness of issuing longer versus shorter duration (3-month vs. 28-day) prescriptions in patients with chronic conditions
Céline Miani, Adam Martin, Josephine Exley, Brett Doble, Ed Wilson, Rupert Payne, Anthony Avery, Catherine Meads, Anne Kirtley, Molly Morgan Jones, Sarah King
May 03, 2018
BACKGROUND: To reduce expenditure on, and wastage of, drugs, some commissioners have encouraged general practitioners to issue shorter prescriptions, typically 28 days in length; however, the evidence base for this...
How does uncertainty shape patient experience in advanced illness? A secondary analysis of qualitative data.
Simon Noah Etkind, Katherine Bristowe, Katharine Bailey, Lucy Ellen Selman, Fliss Em Murtagh
Nov 26, 2020
The challenges of caring for children who require complex medical care at home
BACKGROUND: Increasing numbers of children with complex health-care needs are cared for at home by their family. The aim of this qualitative study was to explore the challenges experienced by families caring for children who...
What influenced people with chronic or refractory breathlessness and advanced disease to take part and remain in a drug trial? A qualitative study.
BACKGROUND: Recruitment and retention in clinical trials remains an important challenge, particularly in the context of advanced disease. It is important to understand what affects retention to improve trial quality, minimise...
breathlessness Palliative Care person-centred care Qualitative randomised controlled trial Recruitment Retention Aged Aged 80 and over Chronic Disease Double-Blind Method Dyspnea Feasibility Studies Female Heart Failure Humans Lung Diseases Interstitial Male Middle Aged motivation Neoplasms Patient Participation Pulmonary Disease Chronic Obstructive qualitative research Quality of life Severity of Illness Index Surveys and Questionnaires United Kingdom
ANCA-Associated Glomerulonephritis
Arda Göçeroğlu, Annelies E Berden, Marta Fiocco, Oliver Flossmann, Kerstin W Westman, Franco Ferrario, Gill Gaskin, Charles D Pusey, E Christiaan Hagen, Laure-Hélène Noël, Niels Rasmussen, Rüdiger Waldherr, Michael Walsh, Jan A Bruijn, David RW Jayne, Ingeborg M Bajema, European Vasculitis Society (EUVAS)
Feb 24, 2020
Relapse in ANCA-associated vasculitis (AAV) has been studied previously, but there are few studies on renal relapse in particular. Identifying patients at high risk of renal relapse may aid in optimizing clinical management. We...
Aged Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies Antineutrophil Cytoplasmic Chronic Disease Europe Female Follow-Up Studies Glomerular Filtration Rate glomerulonephritis Humans Incidence Kidney Kidney Failure Chronic Male Middle Aged Proportional Hazards Models Recurrence Regression Analysis Risk Factors Treatment Outcome
Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts.
Huijun Ying, Hongmei Fu, Marlene L Rose, Ann M McCormack, Padmini Sarathchandra, Klaus Okkenhaug, Federica M Marelli-Berg
Jun 28, 2018
Chronic rejection is the major cause of long-term heart allograft failure, characterized by tissue infiltration by recipient T cells with indirect allospecificity. Phosphoinositol-3-kinase p110δ is a key mediator of T cell...
adenine Animals Cells Cultured Chronic Disease Class Ia Phosphatidylinositol 3-Kinase Female Flow Cytometry Graft Rejection H-Y Antigen Heart Transplantation Humans Immune Tolerance Male Mice Mice Inbred C57BL Mice Knockout Microscopy Fluorescence Phosphoinositide-3 Kinase Inhibitors Quinazolines Skin Transplantation T-Lymphocytes Transplantation Homologous
The importance of definitions in the measurement of long-term health conditions in childhood. Variations in prevalence of long-term health conditions in the UK using data from the Millennium Cohort Study, 2004 - 2015
ABSTRACT
Objectives: To explore the impact of various measurements of long-term health conditions (LTCs) on the resulting prevalence estimates using data from a nationally representative dataset.
Methods: Children and young...
Process evaluation of fidelity and costs of implementing the Integrated Chronic Disease Management model in South Africa
INTRODUCTION: The South African Department of Health has developed and implemented the Integrated Chronic Disease Management (ICDM) model to respond to the increased utilisation of primary healthcare services due to a surge of...
Humans Chronic Disease Models Organizational Health Care Costs Program Development Delivery of Health Care Integrated Disease Management South Africa Process Assessment Health Care
Published by: BMJ Open
Chronic hepatosplenomegaly in African school children
Chronic hepatosplenomegaly, which is known to have a complex aetiology, is common amongst children who reside in rural areas of sub-Saharan Africa. Two of the more common infectious agents of hepatosplenomegaly amongst these...
CAMPHOR score
Michael Newnham, Katherine Bunclark, Nisha Abraham, Samantha Ali, Liliana Amaral-Almeida, John E Cannon, Natalie Doughty, Choo Ng, Anie Ponnaberanam, Karen Sheares, Nicola Speed, Dolores Taboada, Mark Toshner, Steven Tsui, David P Jenkins, Joanna Pepke-Zaba
May 13, 2020
BACKGROUND: Pulmonary endarterectomy (PEA) is the recommended treatment for eligible patients with chronic thromboembolic pulmonary hypertension (CTEPH). The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) score is an...
The Patient Assessment of Chronic Illness Care produces measurements along a single dimension
BACKGROUND: As the worldwide prevalence of chronic illness increases so too does the demand for novel treatments to improve chronic illness care. Quantifying improvement in chronic illness care from the patient perspective...
Chronic subdural haematoma
Peter Hutchinson is supported by a Research Professorship from the National Institute for Health Research (NIHR), the NIHR Cambridge Biomedical Research Centre, a European Union Seventh Framework Program grant (CENTER-TBI; grant...
The need for an integrated approach for chronic disease research and care in Africa.
AL Barr, EH Young, L Smeeth, R Newton, J Seeley, K Ripullone, TR Hird, JRM Thornton, MJ Nyirenda, S Kapiga, CA Adebamowo, AG Amoah, N Wareham, CN Rotimi, NS Levitt, K Ramaiya, BJ Hennig, JC Mbanya, S Tollman, AA Motala, P Kaleebu, MS Sandhu
Jun 19, 2018
With the changing distribution of infectious diseases, and an increase in the burden of non-communicable diseases, low- and middle-income countries, including those in Africa, will need to expand their health care capacities to...
Inverse association between negative symptoms and body mass index in chronic schizophrenia.
G Mezquida, G Savulich, C Garcia-Rizo, MP Garcia-Portilla, A Toll, L Garcia-Alvarez, J Bobes, A Mané, M Bernardo, E Fernandez-Egea
Sep 10, 2018
BACKGROUND: We investigated whether negative symptoms, such as poor motivation or anhedonia, were associated with higher body mass index (BMI) in stable patients with schizophrenia chronically treated with antipsychotic...
Body Mass Index Brief Negative Symptom Scale Clozapine negative symptoms Schizophrenia Adult Age Factors Antipsychotic Agents Benzodiazepines Body Mass Index Chronic Disease Clozapine Female Humans Male Olanzapine principal component analysis Psychiatric Status Rating Scales Regression Analysis Schizophrenia Schizophrenic Psychology
Social relationships and healthful dietary behaviour
Annalijn I Conklin, Nita G Forouhi, Paul Surtees, Kay-Tee Khaw, Nicholas J Wareham, Pablo Monsivais
Sep 21, 2018
Social relationships are an important aspect of a person's social environment that can protect against a wide range of chronic conditions and facilitate recovery from disease. Social relationships have also been linked to...
Chronic Disease Diet variety Gender health behaviour interactions Social relationships Social ties UK Aged Diet Female Fruit Humans Interpersonal Relations Linear Models Male Marital Status Middle Aged Multivariate Analysis Prospective Studies Residence Characteristics Sex Factors Social Isolation United Kingdom Vegetables
Barrett's oESophagus trial 3 (BEST3)
Judith Offman, Beth Muldrew, Maria O'Donovan, Irene Debiram-Beecham, Francesca Pesola, Irene Kaimi, Samuel G Smith, Ashley Wilson, Zohrah Khan, Pierre Lao-Sirieix, Benoit Aigret, Fiona M Walter, Greg Rubin, Steve Morris, Christopher Jackson, Peter Sasieni, Rebecca C Fitzgerald, BEST3 Trial team
Sep 29, 2018
Acceptability Acid reflux biomarker cost effectiveness Early detection endoscopy Heartburn Medical device OESOPHAGEAL CANCER Quality of life Barrett Esophagus Chronic Disease Disease Progression Early Detection of Cancer endoscopy Digestive System Equipment Design Esophageal Neoplasms Female Gastroesophageal Reflux Humans Male Middle Aged Primary Health Care
Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.
Nick Powell, Eirini Pantazi, Polychronis Pavlidis, Anastasia Tsakmaki, Katherine Li, Feifei Yang, Aimee Parker, Carmen Pin, Domenico Cozzetto, Danielle Minns, Emilie Stolarczyk, Svetlana Saveljeva, Rami Mohamed, Paul Lavender, Behdad Afzali, Jonathan Digby-Bell, Tsui Tjir-Li, Arthur Kaser, Joshua Friedman, Thomas T MacDonald, Gavin A Bewick, Graham M Lord
Dec 17, 2019
OBJECTIVE: The functional role of interleukin-22 (IL22) in chronic inflammation is controversial, and mechanistic insights into how it regulates target tissue are lacking. In this study, we evaluated the functional role of IL22...
ER stress Interleukin 22 inflammatory bowel disease Animals Anti-Bacterial Agents Apoptosis Cell Survival Chronic Disease Colitis Colon Crohn Disease Disease Models Animal Endoplasmic reticulum stress Epithelial Cells Gastrointestinal Agents Humans Interleukin-17 Interleukin-23 Interleukins Intestinal Mucosa Mice Organoids Patient acuity Phenylbutyrates Recombinant Proteins Transcription Genetic Tunicamycin Unfolded Protein Response Ustekinumab
SARS-CoV-2 evolution during treatment of chronic infection
Steven A Kemp, Dami A Collier, Rawlings P Datir, Isabella ATM Ferreira, Salma Gayed, Aminu Jahun, Myra Hosmillo, Chloe Rees-Spear, Petra Mlcochova, Ines Ushiro Lumb, David J Roberts, Anita Chandra, Nigel Temperton, The CITIID-NIHR BioResource COVID-19 Collaboration, The COVID-19 Genomics UK (COG-UK) Consortium, Katherine Sharrocks, Elizabeth Blane, Yorgo Modis, Kendra E Leigh, John AG Briggs, Marit J van Gils, Kenneth GC Smith, John R Bradley, Chris Smith, Rainer Doffinger, Lourdes Ceron-Gutierrez, Gabriela Barcenas-Morales, David D Pollock, Richard A Goldstein, Anna Smielewska, Jordan P Skittrall, Theodore Gouliouris, Ian G Goodfellow, Effrossyni Gkrania-Klotsas, Christopher JR Illingworth, Laura E McCoy, Ravindra K Gupta
Jan 28, 2021
Adenosine Monophosphate Aged Alanine Antibodies Neutralizing Antibodies Viral covid-19 Chronic Disease evolution Molecular Genome Viral High-Throughput Nucleotide Sequencing Humans Immune Evasion Immune Tolerance Immunization Passive Immunosuppression Therapy Male Mutagenesis Mutant Proteins Mutation Phylogeny SARS-CoV-2 Spike Glycoprotein Coronavirus Time Factors Viral Load Virus Shedding COVID-19 Drug Treatment COVID-19 Serotherapy
A mixed methods approach to exploring the moderating factors of implementation fidelity of the integrated chronic disease management model in South Africa.
BACKGROUND: Chronic care models like the Integrated Chronic Disease Management (ICDM) model strive to improve the efficiency and quality of care for patients with chronic diseases. However, there is a dearth of studies assessing...
From the Farm to the Clinic
Oral presentation describing the need and development of a "farm to clinic" program to address chronic disease and food insecurity in Eastern North Carolina by connecting local NC agriculture to community-based health clinics.
Published by: Winthrop University
Urinary congophilia in women with hypertensive disorders of pregnancy and preexisting proteinuria or hypertension.
Fergus P McCarthy, Adedamola Adetoba, Carolyn Gill, Kate Bramham, Maria Bertolaccini, Graham J Burton, Guillermina Girardi, Paul T Seed, Lucilla Poston, Lucy C Chappell
Jun 01, 2016
Congo red Amyloid chronic kidney disease Preeclampsia renal disease Unfolded Protein Response urine congophilia Adult Amyloidogenic Proteins Case-Control Studies Chronic Disease Coloring Agents Congo Red Female Humans Hypertension Lupus Nephritis pre-eclampsia Pregnancy Proteinuria Renal Insufficiency Chronic Young Adult
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