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Gerald Edelman, 1973
The Rockefeller University
Jan 01, 0001
Gerald M. Edelman. Antibody structure and cellular specificity in the immune response
Lecture delivered January 18th, 1973
Posted with permission
Published by: Academic Press
Regulation of the Germinal Center Response.
Marisa Stebegg, Saumya D Kumar, Alyssa Silva-Cayetano, Valter R Fonseca, Michelle A Linterman, Luis Graca
Jun 24, 2019
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection. Within...
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
Espen Melum, Xiaojun Jiang, Kristi D Baker, M Fatima Macedo, Jürgen Fritsch, C Marie Dowds, Jing Wang, Anne Pharo, Arthur Kaser, Corey Tan, Catia S Pereira, Samuel L Kelly, Jingjing Duan, Tom H Karlsen, Mark A Exley, Stefan Schütze, Dirk M Zajonc, Alfred H Merrill, Edward H Schuchman, Sebastian Zeissig, Richard S Blumberg
Sep 23, 2019
Invariant natural killer T (iNKT) cells recognize activating self and microbial lipids presented by CD1d. CD1d can also bind non-activating lipids, such as sphingomyelin. We hypothesized that these serve as endogenous regulators...
Animals Antigen Presentation Antigens CD1d Cell Differentiation Clonal Selection Antigen-Mediated Enzyme Replacement Therapy Humans Inflammation Lymphocyte Activation Lymphocyte Count Mice Mice Inbred C57BL Mice Knockout Natural Killer T-Cells Niemann-Pick Diseases Sphingomyelin Phosphodiesterase Sphingomyelins Thymus Gland
Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.
Frank Penkava, Martin Del Castillo Velasco-Herrera, Matthew D Young, Nicole Yager, Lilian N Nwosu, Arthur G Pratt, Alicia Lledo Lara, Charlotte Guzzo, Ash Maroof, Lira Mamanova, Suzanne Cole, Mirjana Efremova, Davide Simone, Andrew Filer, Chrysothemis C Brown, Andrew L Croxford, John D Isaacs, Sarah Teichmann, Paul Bowness, Sam Behjati, M Hussein Al-Mossawi
Oct 23, 2020
Synovial Membrane Synovial Fluid CD8-Positive T-Lymphocytes Humans Arthritis Psoriatic Receptors Lymphocyte Homing Receptors Chemokine Receptors Antigen T-Cell alpha-beta Gene Expression Profiling Immunologic Memory Single-Cell Analysis Clonal Selection Antigen-Mediated
Published by: Nature Communications
The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.
Elisa Monzón-Casanova, Michael Screen, Manuel D Díaz-Muñoz, Richard Mr Coulson, Sarah E Bell, Greta Lamers, Michele Solimena, Christopher WJ Smith, Martin Turner
Aug 30, 2018
Antibody affinity maturation occurs in germinal centers (GCs), where B cells cycle between the light zone (LZ) and the dark zone. In the LZ, GC B cells bearing immunoglobulins with the highest affinity for antigen receive...
Influence of correlated antigen presentation on T-cell negative selection in the thymus.
The thymus is the primary organ for the generation of naive T cells, a key component of the immune system. Tolerance of T cells to self is achieved primarily in the thymic medulla, where immature T cells (thymocytes) sample...
Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.
Frank Penkava, Martin Del Castillo Velasco-Herrera, Matthew D Young, Nicole Yager, Lilian N Nwosu, Arthur G Pratt, Alicia Lledo Lara, Charlotte Guzzo, Ash Maroof, Lira Mamanova, Suzanne Cole, Mirjana Efremova, Davide Simone, Andrew Filer, Chrysothemis C Brown, Andrew L Croxford, John D Isaacs, Sarah Teichmann, Paul Bowness, Sam Behjati, M Hussein Al-Mossawi
Nov 20, 2020
Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary single-cell approaches to study leukocytes...