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Results: 168
The AMBER care bundle for hospital inpatients with uncertain recovery nearing the end of life
Jonathan Koffman, Emel Yorganci, Fliss Murtagh, Deokhee Yi, Wei Gao, Stephen Barclay, Andrew Pickles, Irene Higginson, Halle Johnson, Rebecca Wilson, Sylvia Bailey, Colleen Ewart, Catherine Evans
Oct 22, 2019
BACKGROUND: Patients admitted to hospital with a terminal illness and uncertain recovery often receive inconsistent care and do not have the opportunity to die in their preferred place of death. Previous end-of-life care...
clinical uncertainty complex intervention end of life care FEASIBILITY CLUSTER RCT mixed methods outcomes Palliative Care Aged Aged 80 and over Cluster Analysis England Feasibility Studies Female Focus Groups Hospitalization Humans Inpatients Interviews as Topic Male Middle Aged Patient Care Bundles qualitative research Terminal Care uncertainty
Souporcell
Haynes Heaton, Arthur M Talman, Andrew Knights, Maria Imaz, Daniel J Gaffney, Richard Durbin, Martin Hemberg, Mara Kn Lawniczak
Apr 01, 2020
A prevention program for multiple health-compromising behaviors in adolescence
Elias Allara, Paola Angelini, Giuseppe Gorini, Sandra Bosi, Giulia Carreras, Cristina Gozzi, Andrea Martini, Marco Tamelli, Simone Storani, Fabrizio Faggiano
Jun 27, 2019
adolescence Alcohol cluster randomized controlled trial Dietary risks eating behavior Evidence-based prevention physical activity School-based prevention Tobacco Youth Adolescent Adolescent Behavior Alcohol Drinking Beverages Child Cluster Analysis Diet Feeding Behavior Female Health Behavior Health Promotion Humans Italy Male Motor Activity Program Evaluation Risk-Taking Schools Smoking Smoking Prevention Students Surveys and Questionnaires
Managing uncertain recovery for patients nearing the end of life in hospital
J Koffman, E Yorganci, D Yi, W Gao, F Murtagh, A Pickles, S Barclay, H Johnson, R Wilson, L Sampson, J Droney, M Farquhar, T Prevost, CJ Evans
Aug 19, 2019
BACKGROUND: The AMBER (Assessment, Management, Best Practice, Engagement, Recovery Uncertain) care bundle is a complex intervention used in UK hospitals to support patients with uncertain recovery. However, it has yet to be...
AMBER care bundle feasibility study clinical trial clinical uncertainty complex intervention end-of-life care mixed methods Palliative Care Aged Aged 80 and over Cluster Analysis Feasibility Studies Female Humans Male Middle Aged Patient Care Bundles Patient Selection Prospective Studies Research Design Terminal Care uncertainty
Admissible multiarm stepped-wedge cluster randomized trial designs.
Numerous publications have now addressed the principles of designing, analyzing, and reporting the results of stepped-wedge cluster randomized trials. In contrast, there is little research available pertaining to the design and...
Unmasking herd protection by an oral cholera vaccine in a cluster-randomized trial.
Mohammad Ali, Firdausi Qadri, Deok Ryun Kim, Taufiqul Islam, Justin Im, Faisal Ahmmed, Yun Chon, Ashraful Islam Khan, Khalequ Zaman, Florian Marks, John D Clemens
Apr 18, 2019
BACKGROUND: Several studies have shown that inactivated, whole-cell oral cholera vaccines (OCVs) confer both direct protection on vaccinees and herd protection on populations. Because our earlier cluster-randomized effectiveness...
Cholera cluster-randomized trial fried-egg design vaccine effectiveness Administration Oral Adolescent Adult Aged Bangladesh Child Child Preschool Cholera Cholera Vaccines Cluster Analysis Female Humans Immunity Herd Infant Male Middle Aged Poverty Areas Proportional Hazards Models Treatment Outcome Urban Population Vaccination vaccines Inactivated Young Adult
Clustering identifies endotypes of traumatic brain injury in an intensive care cohort- a CENTER-TBI study
Cecilia AI Åkerlund, Anders Holst, Nino Stocchetti, Ewout W Steyeerberg, David K Menon, Ari Ercole, David W Nelson, CENTER-TBI Participants and Investigators
Sep 02, 2022
Transcriptional changes in the mammary gland during lactation revealed by single cell sequencing of cells from human milk.
Alecia-Jane Twigger, Lisa K Engelbrecht, Karsten Bach, Isabel Schultz-Pernice, Sara Pensa, Jack Stenning, Stefania Petricca, Christina H Scheel, Walid T Khaled
Mar 02, 2022
Effects of new motorway infrastructure on active travel in the local population
Active travel evaluation Natural experiment physical activity Adolescent Adult Bicycling Cities Cluster Analysis Cross-Sectional Studies Environment Design Exercise Female Humans Male Middle Aged Retrospective Studies Safety Scotland Surveys and Questionnaires Travel Urban Population Walking Young Adult
Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes
L Tao, ECF Wilson, NJ Wareham, A Sandbaek, GEHM Rutten, T Lauritzen, K Khunti, MJ Davies, K Borch-Johnsen, SJ Griffin, RK Simmons
Aug 11, 2014
Aged Cluster Analysis Cohort Studies Combined Modality Therapy Cost-Benefit Analysis Diabetes Complications Diabetes mellitus Type 2 Female Health Care Costs Humans Incidence Male Mass Screening Middle Aged Patient Education as Topic Patient-Centered Care Quality-Adjusted Life Years Risk Factors Time Factors United Kingdom
Fast Nonparametric Clustering of Structured Time-Series.
In this publication, we combine two Bayesian nonparametric models: the Gaussian Process (GP) and the Dirichlet Process (DP). Our innovation in the GP model is to introduce a variation on the GP prior which enables us to model...
Sphere-sphere intersection for investment portfolio diversification - A new data-driven cluster analysis.
Michel Ferreira Cardia Haddad
Jan 29, 2020
Aiming at supporting the process of investment portfolio diversification by using a data-driven approach, the present methodological paper proposes a new cluster analysis, which compares publicly traded companies, mainly in...
Functional module detection through integration of single-cell RNA sequencing data with protein-protein interaction networks.
Florian Klimm, Enrique M Toledo, Thomas Monfeuga, Fang Zhang, Charlotte M Deane, Gesine Reinert
Nov 03, 2020
MR-Clust
MOTIVATION: Mendelian randomization is an epidemiological technique that uses genetic variants as instrumental variables to estimate the causal effect of a risk factor on an outcome. We consider a scenario in which causal...
Multiple kernel learning for integrative consensus clustering of omic datasets.
MOTIVATION: Diverse applications-particularly in tumour subtyping-have demonstrated the importance of integrative clustering techniques for combining information from multiple data sources. Cluster Of Clusters Analysis (COCA) is...
Gene expression during Drosophila melanogaster egg development before and after reproductive diapause.
BACKGROUND: Despite the importance of egg development to the female life cycle in Drosophila, global patterns of gene expression have not been examined in detail, primarily due to the difficulty in isolating synchronised...
Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge)
Rebecca K Simmons, Justin B Echouffo-Tcheugui, Stephen J Sharp, Lincoln A Sargeant, Kate M Williams, A Toby Prevost, Ann Louise Kinmonth, Nicholas J Wareham, Simon J Griffin
Jun 12, 2018
BACKGROUND: The increasing prevalence of type 2 diabetes poses a major public health challenge. Population-based screening and early treatment for type 2 diabetes could reduce this growing burden. However, uncertainty persists...
A note on obtaining correct marginal predictions from a random intercepts model for binary outcomes.
BACKGROUND: Clustered data with binary outcomes are often analysed using random intercepts models or generalised estimating equations (GEE) resulting in cluster-specific or 'population-average' inference, respectively. METHODS...
Multilevel models for cost-effectiveness analyses that use cluster randomised trial data
Edmond S-W Ng, Karla Diaz-Ordaz, Richard Grieve, Richard M Nixon, Simon G Thompson, James R Carpenter
Nov 16, 2017
Multilevel models provide a flexible modelling framework for cost-effectiveness analyses that use cluster randomised trial data. However, there is a lack of guidance on how to choose the most appropriate multilevel models. This...
Cancer stem cell markers in breast cancer
H Raza Ali, Sarah-Jane Dawson, Fiona M Blows, Elena Provenzano, Paul D Pharoah, Carlos Caldas
Dec 23, 2011
INTRODUCTION: The cancer stem cell (CSC) hypothesis states that tumours consist of a cellular hierarchy with CSCs at the apex driving tumour recurrence and metastasis. Hence, CSCs are potentially of profound clinical importance....
Differential expression of selected histone modifier genes in human solid cancers.
Hilal Ozdağ, Andrew E Teschendorff, Ahmed Ashour Ahmed, Sarah J Hyland, Cherie Blenkiron, Linda Bobrow, Abhi Veerakumarasivam, Glynn Burtt, Tanya Subkhankulova, Mark J Arends, V Peter Collins, David Bowtell, Tony Kouzarides, James D Brenton, Carlos Caldas
Jun 14, 2011
Breast Neoplasms Carcinoma Cell Transformation Neoplastic Cluster Analysis Colorectal Neoplasms DNA Complementary DNA Neoplasm Female Gene Expression Regulation Enzymologic Gene Expression Regulation Neoplastic Histone Acetyltransferases Histone Code Histone Deacetylases Histone Methyltransferases Histone-Lysine N-Methyltransferase Histones Humans Linear Models Lung Neoplasms Male Neoplasm Proteins Neoplasms Ovarian Neoplasms Pancreatic Neoplasms Polymerase Chain Reaction Polymorphism Single-Stranded Conformational Protein Methyltransferases Protein Processing Post-Translational
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