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Results: 163
Structural correlates of cognitive impairment in normal pressure hydrocephalus.
Katie A Peterson, Tom B Mole, Nicole CH Keong, Elise E DeVito, George Savulich, John D Pickard, Barbara J Sahakian
Dec 14, 2018
Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI).
Ingrid Arevalo-Rodriguez, Nadja Smailagic, Marta Roqué I Figuls, Agustín Ciapponi, Erick Sanchez-Perez, Antri Giannakou, Olga L Pedraza, Xavier Bonfill Cosp, Sarah Cullum
Oct 10, 2018
BACKGROUND: Dementia is a progressive global cognitive impairment syndrome. In 2010, more than 35 million people worldwide were estimated to be living with dementia. Some people with mild cognitive impairment (MCI) will progress...
123I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults.
Gemma Roberts, James J Lloyd, George S Petrides, Paul C Donaghy, Joseph PM Kane, Rory Durcan, Sarah Lawley, Kim Howe, Andrew J Sims, John-Paul Taylor, John T O'Brien, Alan J Thomas
Mar 22, 2019
Continuous performance test impairment in a 22q11.2 microdeletion mouse model
Simon RO Nilsson, Christopher J Heath, Samir Takillah, Steve Didienne, Kim Fejgin, Vibeke Nielsen, Jacob Nielsen, Lisa M Saksida, Jean Mariani, Philippe Faure, Michael Didriksen, Trevor W Robbins, Timothy J Bussey, Adam C Mar
Jan 14, 2019
The 22q11.2 deletion syndrome (22q11.2DS) confers high risk of neurodevelopmental disorders such as schizophrenia and attention-deficit hyperactivity disorder. These disorders are associated with attentional impairment, the...
Peripheral inflammation in prodromal Alzheimer's and Lewy body dementias.
Eleanor King, John Tiernan O'Brien, Paul Donaghy, Christopher Morris, Nicola Barnett, Kirsty Olsen, Carmen Martin-Ruiz, John-Paul Taylor, Alan J Thomas
Jan 29, 2018
Aged Aged 80 and over Alzheimer Disease C-Reactive Protein Case-Control Studies Cognitive Dysfunction Cytokines Female Humans Inflammation Interferon-gamma Interleukin-10 Interleukin-12 Interleukin-13 Interleukin-1beta Interleukin-2 Interleukin-4 Interleukin-6 Interleukin-8 Lewy Body Disease Male Prodromal Symptoms Tumor Necrosis Factor-alpha
Stability of mild cognitive impairment in newly diagnosed Parkinson's disease.
Rachael A Lawson, Alison J Yarnall, Gordon W Duncan, David P Breen, Tien K Khoo, Caroline H Williams-Gray, Roger A Barker, David J Burn, ICICLE-PD study group
Aug 16, 2017
BACKGROUND: Mild cognitive impairment (MCI) is common in early Parkinson's disease (PD). We evaluated the stability of PD-MCI over time to determine its clinical utility as a marker of disease. METHODS: 212 newly diagnosed...
A smartphone-based test for the assessment of attention deficits in delirium
Zoë Tieges, David J Stott, Robert Shaw, Elaine Tang, Lisa-Marie Rutter, Eva Nouzova, Nikki Duncan, Caoimhe Clarke, Christopher J Weir, Valentina Assi, Hannah Ensor, Jennifer H Barnett, Jonathan Evans, Samantha Green, Kirsty Hendry, Meigan Thomson, Jenny McKeever, Duncan G Middleton, Stuart Parks, Tim Walsh, Alexander J Weir, Elizabeth Wilson, Tara Quasim, Alasdair MJ MacLullich
Mar 09, 2020
BACKGROUND: Delirium is a common and serious acute neuropsychiatric syndrome which is often missed in routine clinical care. Inattention is the core cognitive feature. Diagnostic test accuracy (including cut-points) of a...
Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease.
Joseph Giorgio, Susan M Landau, William J Jagust, Peter Tino, Zoe Kourtzi, Alzheimer's Disease Neuroimaging Initiative
Jan 28, 2020
Alzheimer's disease brain imaging Cognition Machine Learning mild cognitive impairment Aged Alzheimer Disease Brain Cognitive Dysfunction Disease Progression Female Humans Image Interpretation Computer-Assisted Machine Learning Magnetic Resonance Imaging Male Middle Aged Models Neurological Neuroimaging Prognosis
Association of aortic stiffness with cognitive decline
Marzieh Araghi, Martin J Shipley, Ian B Wilkinson, Carmel M McEniery, Carlos A Valencia-Hernández, Mika Kivimaki, Séverine Sabia, Archana Singh-Manoux, Eric J Brunner
Nov 13, 2019
Aortic stiffness is associated with an increased risk of cardio- and cerebrovascular disease and mortality and may increase risk of dementia. The aim of the present study is to examine the association between arterial stiffness...
Ageing arterial stiffness cognitive decline Pulse-wave velocity Aged arteries Cognition Cognitive Dysfunction Cohort Studies Female Health Behavior Humans Longitudinal Studies Male Memory Disorders Middle Aged Prospective Studies Pulse Wave Analysis Risk Factors Severity of Illness Index Vascular Stiffness
Prospective predictors of decline v. stability in mild cognitive impairment with Lewy bodies or Alzheimer's disease.
Calum A Hamilton, Fiona E Matthews, Paul C Donaghy, John-Paul Taylor, John T O'Brien, Nicola Barnett, Kirsty Olsen, Ian G McKeith, Alan J Thomas
Apr 14, 2020
BACKGROUND: Mild cognitive impairment (MCI) may gradually worsen to dementia, but often remains stable for extended periods of time. Little is known about the predictors of decline to help explain this variation. We aimed to...
Alzheimer's Disease dementia with Lewy bodies latent class mixture modelling longitudinal decline mild cognitive impairment Aged Aged 80 and over Alzheimer Disease Cognitive Dysfunction Disease Progression England Female Humans latent class analysis Lewy Bodies Lewy Body Disease Longitudinal Studies Male Middle Aged Prospective Studies
Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease
MJ Firbank, AJ Yarnall, RA Lawson, GW Duncan, TK Khoo, GS Petrides, JT O'Brien, RA Barker, RJ Maxwell, DJ Brooks, DJ Burn
Oct 14, 2016
A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey.
Lydia Oikonomidis, Andrea M Santangelo, Yoshiro Shiba, F Hannah Clarke, Trevor W Robbins, Angela C Roberts
Oct 28, 2016
Use of Immersive Virtual Reality in the Assessment and Treatment of Alzheimer's Disease
BACKGROUND: Immersive virtual reality (iVR) allows seamless interaction with simulated environments and is becoming an established tool in clinical research. It is unclear whether iVR is acceptable to people with Alzheimer's...
Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease
Calum A Hamilton, Fiona E Matthews, Paul C Donaghy, John-Paul Taylor, John T O'Brien, Nicola Barnett, Kirsty Olsen, Jim Lloyd, George Petrides, Ian G McKeith, Alan J Thomas
Aug 07, 2020
OBJECTIVE: We explored whether the mild cognitive impairment (MCI) stages of dementia with Lewy bodies (DLB) and Alzheimer disease (AD) differ in their cognitive profiles, and longitudinal progression. DESIGN: A prospective...
The use of commercial computerised cognitive games in older adults
Brain training programs are currently one effective solution to prevent cognitive decline in healthy aging. We conducted a meta-analysis of randomized controlled trials assessing the use of commercially available computerised...
Mild cognitive impairment with Lewy bodies
Michael J Firbank, John T O'Brien, Rory Durcan, Louise M Allan, Sally Barker, Joanna Ciafone, Paul C Donaghy, Calum A Hamilton, Sarah Lawley, Jim Lloyd, Gemma Roberts, John-Paul Taylor, Alan J Thomas
Oct 12, 2020
OBJECTIVE: To use arterial spin labelling to investigate differences in perfusion in mild cognitive impairment with Lewy bodies (MCI-LB) compared to Alzheimer type MCI (MCI-AD) and healthy controls. METHODS: We obtained...
The Relationship Between Cognitive Performance Using Tests Assessing a Range of Cognitive Domains and Future Dementia Diagnosis in a British Cohort
Reprogramming Human Adult Fibroblasts into GABAergic Interneurons.
Andreas Bruzelius, Srisaiyini Kidnapillai, Janelle Drouin-Ouellet, Tom Stoker, Roger A Barker, Daniella Rylander Ottosson
Jan 28, 2022
Direct reprogramming is an appealing strategy to generate neurons from a somatic cell by forced expression of transcription factors. The generated neurons can be used for both cell replacement strategies and disease modelling....
adult skin cells calbindin direct reprogramming disease-modelling Electrophysiology iN neuronal conversion Adult Brain Diseases Cell Differentiation Cellular Reprogramming Cognitive Dysfunction FIBROBLASTS GABAergic Neurons Gene Expression Regulation Humans Interneurons Neurogenesis Neuroglia Repressor Proteins Skin gamma-Aminobutyric Acid
Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson's Disease in the ICICLE-PD Cohort.
Rachael A Lawson, Caroline H Williams-Gray, Marta Camacho, Gordon W Duncan, Tien K Khoo, David P Breen, Roger A Barker, Lynn Rochester, David J Burn, Alison J Yarnall, ICICLE-PD study group
May 28, 2021
BACKGROUND: Cognitive impairment is common in Parkinson's disease (PD), with 80% cumulatively developing dementia (PDD). OBJECTIVE: We sought to identify tests that are sensitive to change over time above normal ageing so as to...
White matter microstructural abnormalities in children with severe congenital hypothyroidism.
Hannah E Cooper, Enrico Kaden, Lorna F Halliday, Doris-Eva Bamiou, Kshitij Mankad, Catherine Peters, Christopher A Clark
Oct 14, 2019
Spatial Covariance of Cholinergic Muscarinic M1 /M4 Receptors in Parkinson's Disease.
Sean J Colloby, Pradeep J Nathan, Geor Bakker, Rachael A Lawson, Alison J Yarnall, David J Burn, John T O'Brien, John-Paul Taylor
Mar 04, 2021
BACKGROUND: Parkinson's disease (PD) is associated with cholinergic dysfunction, although the role of M1 and M4 receptors remains unclear. OBJECTIVE: To investigate spatial covariance patterns of cholinergic muscarinic M1 /M4...
Hippocampal and insula volume in mild cognitive impairment with Lewy bodies.
Michael J Firbank, Rory Durcan, John T O'Brien, Louise M Allan, Sally Barker, Joanna Ciafone, Paul C Donaghy, Calum A Hamilton, Sarah Lawley, Gemma Roberts, John-Paul Taylor, Alan J Thomas
Mar 15, 2021
Involvement of the reward network is associated with apathy in cerebral small vessel disease.
Danuta M Lisiecka-Ford, Daniel J Tozer, Robin G Morris, Andrew J Lawrence, Thomas R Barrick, Hugh S Markus
May 01, 2018
INTRODUCTION: Apathy is a common yet under-recognised feature of cerebral small vessel disease (SVD), but its underlying neurobiological basis is not yet understood. We hypothesized that damage to the reward network is...
The motor and cognitive features of Parkinson's disease in patients with concurrent Gaucher disease over 2 years
Lucy M Collins, Caroline H Williams-Gray, Elizabeth Morris, Patrick Deegan, Timothy M Cox, Roger A Barker
May 22, 2018
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