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Improving phase II oncology trials using best observed RECIST response as an endpoint by modelling continuous tumour measurements.
In many phase II trials in solid tumours, patients are assessed using endpoints based on the Response Evaluation Criteria in Solid Tumours (RECIST) scale. Often, analyses are based on the response rate. This is the proportion of...
continuous tumour shrinkage endpoints longitudinal model phase II cancer trial Clinical Trials Phase II as Topic Colonic Neoplasms Computer Simulation Disease Progression Endpoint Determination Humans Logistic Models Medical Oncology Neoplasms Randomized Controlled Trials as Topic Research Design Treatment Outcome
Age-related inequalities in colon cancer treatment persist over time
Louise Hayes, Lynne Forrest, Jean Adams, Mira Hidajat, Yoav Ben-Shlomo, Martin White, Linda Sharp
Jun 12, 2020
BACKGROUND: Older people experience poorer outcomes from colon cancer. We examined if treatment for colon cancer was related to age and if inequalities changed over time. METHODS: Data from the UK population-based Northern and...
Circulating tumor DNA in patients with colorectal adenomas
Ni Ni Moe Myint, Ajay M Verma, Daniel Fernandez-Garcia, Panchali Sarmah, Patrick S Tarpey, Saif Sattar Al-Aqbi, Hong Cai, Ricky Trigg, Kevin West, Lynne M Howells, Anne Thomas, Karen Brown, David S Guttery, Baljit Singh, Howard J Pringle, Ultan McDermott, Jacqui A Shaw, Alessandro Rufini
Nov 22, 2018
Improving early detection of colorectal cancer (CRC) is a key public health priority as adenomas and stage I cancer can be treated with minimally invasive procedures. Population screening strategies based on detection of occult...
Adenoma Adenomatous Polyposis Coli Protein Aged Aged 80 and over Animals Biomarkers Tumor Circulating Tumor DNA Colonic Neoplasms Early Detection of Cancer Female High-Throughput Nucleotide Sequencing Humans Liquid biopsy Male Mice Mice Knockout Middle Aged Polymerase Chain Reaction Proto-Oncogene Proteins B-raf Proto-Oncogene Proteins p21(ras)
De novo design of potent and selective mimics of IL-2 and IL-15.
Daniel-Adriano Silva, Shawn Yu, Umut Y Ulge, Jamie B Spangler, Kevin M Jude, Carlos Labão-Almeida, Lestat R Ali, Alfredo Quijano-Rubio, Mikel Ruterbusch, Isabel Leung, Tamara Biary, Stephanie J Crowley, Enrique Marcos, Carl D Walkey, Brian D Weitzner, Fátima Pardo-Avila, Javier Castellanos, Lauren Carter, Lance Stewart, Stanley R Riddell, Marion Pepper, Gonçalo JL Bernardes, Michael Dougan, K Christopher Garcia, David Baker
Jan 29, 2019
We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence. We use this strategy to design mimics...
Amino Acid Sequence Animals Binding Sites Colonic Neoplasms Computer Simulation Crystallography X-Ray Disease Models Animal Drug Design Humans Interleukin-15 Interleukin-2 Interleukin-2 Receptor alpha Subunit Melanoma Mice Models Molecular Molecular Mimicry Protein Stability Receptors Interleukin-2 Signal Transduction
Right hemicolectomy with complete mesocolic excision is safe, leads to an increased lymph node yield and to increased survival
Platelets from patients with visceral obesity promote colon cancer growth.
Marica Cariello, Elena Piccinin, Emanuela Pasculli, Maria Arconzo, Roberta Zerlotin, Simona D'Amore, Francesca Mastropasqua, Claudia Peres, Giusi Graziano, Gaetano Villani, Graziano Pesole, Antonio Moschetta
Jul 08, 2022
Several studies highlighted the importance of platelets in the tumor microenvironment due to their ability to interact with other cell types such as leukocytes, endothelial, stromal and cancer cells. Platelets can influence...
Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication.
Iosifina P Foskolou, Christian Jorgensen, Katarzyna B Leszczynska, Monica M Olcina, Hanna Tarhonskaya, Bauke Haisma, Vincenzo D'Angiolella, William K Myers, Carmen Domene, Emily Flashman, Ester M Hammond
May 11, 2020
Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide...
DNA damage response p53 RNR RRM2B Hypoxia Nucleotides radiosensitivity replication stress Animals Apoptosis Cell Cycle Proteins Colonic Neoplasms DNA Damage DNA Replication DNA Neoplasm Female HCT116 Cells Humans Mice Inbred BALB C Mice Nude Oxygen RNA Interference Radiation Tolerance Ribonucleoside Diphosphate Reductase Ribonucleotide Reductases Time Factors Transfection Tumor Burden Tumor Hypoxia Tumor Suppressor Proteins Xenograft Model Antitumor Assays
Persistent inequalities in unplanned hospitalisation among colon cancer patients across critical phases of their care pathway, England, 2011-13.
BACKGROUND: Reducing hospital emergency admissions is a key target for all modern health systems. METHODS: We analysed colon cancer patients diagnosed in 2011-13 in England. We screened their individual Hospital Episode...
Socio-demographic variation in stage at diagnosis of breast, bladder, colon, endometrial, lung, melanoma, prostate, rectal, renal and ovarian cancer in England and its population impact.
BACKGROUND: Stage at diagnosis strongly predicts cancer survival and understanding related inequalities could guide interventions. METHODS: We analysed incident cases diagnosed with 10 solid tumours included in the UK government...
Adult Aged Aged 80 and over Breast Neoplasms Colonic Neoplasms Demography Endometrial Neoplasms England Female Follow-Up Studies Humans Kidney Neoplasms Lung Neoplasms Male Melanoma Middle Aged Neoplasms Ovarian Neoplasms Prognosis Prostatic Neoplasms Rectal Neoplasms Socioeconomic Factors Urinary Bladder Neoplasms
Activation of the GPR35 pathway drives angiogenesis in the tumour microenvironment.
Ester Pagano, Joshua E Elias, Georg Schneditz, Svetlana Saveljeva, Lorraine M Holland, Francesca Borrelli, Tom H Karlsen, Arthur Kaser, Nicole C Kaneider
Mar 15, 2021
Long splenic flexure carcinoma requiring laparoscopic extended left hemicolectomy with CME and transverse-rectal anastomosis
Salomone Di Saverio, Kostantinos Stasinos, Weronyka Stupalkowska, Umberto Bracale, Pierpaolo Sileri, Antonio Giuliani, Giuseppe Nigri, Efstratios Kouroumpas, James MD Wheeler, Giovanni Domenico Tebala, Francesco Di Marzo, Belinda De Simone, Carlos Pastor Idoate, Nicola De Angelis, Roberto Cirocchi, Patricia Tejedor
Feb 16, 2022
A global systematic review and meta-analysis on laparoscopic vs open right hemicolectomy with complete mesocolic excision.
Gabriele Anania, Alberto Arezzo, Richard Justin Davies, Francesco Marchetti, Shu Zhang, Salomone Di Saverio, Roberto Cirocchi, Annibale Donini
Jul 28, 2021
Single-copy Snail upregulation causes partial epithelial-mesenchymal transition in colon cancer cells.
Whole-body MRI compared with standard pathways for staging metastatic disease in lung and colorectal cancer
Stuart A Taylor, Susan Mallett, Anne Miles, Stephen Morris, Laura Quinn, Caroline S Clarke, Sandy Beare, John Bridgewater, Vicky Goh, Sam Janes, Dow-Mu Koh, Alison Morton, Neal Navani, Alfred Oliver, Anwar Padhani, Shonit Punwani, Andrea Rockall, Steve Halligan
Sep 11, 2020
BACKGROUND: Whole-body magnetic resonance imaging is advocated as an alternative to standard pathways for staging cancer. OBJECTIVES: The objectives were to compare diagnostic accuracy, efficiency, patient acceptability...
Colonic Neoplasms COST–BENEFIT ANALYSIS Lung Neoplasms Magnetic Resonance Imaging Prospective Studies Sensitivity and Specificity Technology Assessment WHOLE-BODY IMAGING Aged Carcinoma Non-Small-Cell Lung Colorectal Neoplasms England Female Humans Magnetic Resonance Imaging Male Middle Aged Neoplasm Staging Positron-Emission Tomography Prospective Studies Sensitivity and Specificity Tomography X-Ray Computed Whole Body Imaging
Survival outcomes associated with completion of adjuvant oxaliplatin-based chemotherapy for stage III colon cancer
Jemma M Boyle, Angela Kuryba, Thomas E Cowling, Jan van der Meulen, Nicola S Fearnhead, Kate Walker, Michael S Braun, Ajay Aggarwal
Sep 29, 2021
The impact of cycle completion rates of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer in real-world practice is unknown. We assessed its impact, and that of treatment modification, on 3-year cancer-specific...
adjuvant chemotherapy colon cancer completion of treatment EPIDEMIOLOGY stage III survival Aged Aged 80 and over Antineoplastic Combined Chemotherapy Protocols Capecitabine Chemotherapy Adjuvant Colonic Neoplasms Female Fluorouracil Follow-Up Studies Humans Leucovorin Male Middle Aged Neoplasm Staging Oxaliplatin Prospective Studies Survival Rate
Emergency surgery for splenic flexure cancer
Nicola de'Angelis, Eloy Espin, Frederic Ris, Filippo Landi, Bertrand Le Roy, Federico Coccolini, Valerio Celentano, Angela Gurrado, Denis Pezet, Giorgio Bianchi, Riccardo Memeo, Giulio C Vitali, Alejandro Solis, Christine Denet, Salomone Di Saverio, Gian Luigi de'Angelis, Miquel Kraft, Paula Gonzálvez-Guardiola, Aine Stakelum, Fausto Catena, David Fuks, Des C Winter, Mario Testini, Aleix Martínez-Pérez, SFC Study Group
Apr 30, 2021
BACKGROUND: The effectiveness of surgical treatment for splenic flexure carcinomas (SFCs) in emergency settings remains unexplored. This study aims to compare the perioperative and long-term outcomes of different alternatives...
Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study
Adam Naguib, James C Cooke, Lisa Happerfield, Lucy Kerr, Laura J Gay, Robert N Luben, Richard Y Ball, Panagiota N Mitrou, Alison McTaggart, Mark J Arends
Jun 16, 2011
Adenocarcinoma Aged Aged 80 and over Class I Phosphatidylinositol 3-Kinases Colonic Neoplasms DNA Mutational Analysis Disease Progression Female Gene Expression Regulation Neoplastic Genetic Association Studies Humans Immunohistochemistry Male Middle Aged Mutation PTEN Phosphohydrolase Phosphatidylinositol 3-Kinases Proto-Oncogene Mas Sex Factors Surveys and Questionnaires
Genetic architectures of proximal and distal colorectal cancer are partly distinct.
Jeroen R Huyghe, Tabitha A Harrison, Stephanie A Bien, Heather Hampel, Jane C Figueiredo, Stephanie L Schmit, David V Conti, Sai Chen, Conghui Qu, Yi Lin, Richard Barfield, John A Baron, Amanda J Cross, Brenda Diergaarde, David Duggan, Sophia Harlid, Liher Imaz, Hyun Min Kang, David M Levine, Vittorio Perduca, Aurora Perez-Cornago, Lori C Sakoda, Fredrick R Schumacher, Martha L Slattery, Amanda E Toland, Fränzel JB van Duijnhoven, Bethany Van Guelpen, Antonio Agudo, Demetrius Albanes, M Henar Alonso, Kristin Anderson, Coral Arnau-Collell, Volker Arndt, Barbara L Banbury, Michael C Bassik, Sonja I Berndt, Stéphane Bézieau, D Timothy Bishop, Juergen Boehm, Heiner Boeing, Marie-Christine Boutron-Ruault, Hermann Brenner, Stefanie Brezina, Stephan Buch, Daniel D Buchanan, Andrea Burnett-Hartman, Bette J Caan, Peter T Campbell, Prudence R Carr, Antoni Castells, Sergi Castellví-Bel, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Keith R Curtis, Albert de la Chapelle, Douglas F Easton, Dallas R English, Edith JM Feskens, Manish Gala, Steven J Gallinger, W James Gauderman, Graham G Giles, Phyllis J Goodman, William M Grady, John S Grove, Andrea Gsur, Marc J Gunter, Robert W Haile, Jochen Hampe, Michael Hoffmeister, John L Hopper, Wan-Ling Hsu, Wen-Yi Huang, Thomas J Hudson, Mazda Jenab, Mark A Jenkins, Amit D Joshi, Temitope O Keku, Charles Kooperberg, Tilman Kühn, Sébastien Küry, Loic Le Marchand, Flavio Lejbkowicz, Christopher I Li, Li Li, Wolfgang Lieb, Annika Lindblom, Noralane M Lindor, Satu Männistö, Sanford D Markowitz, Roger L Milne, Lorena Moreno, Neil Murphy, Rami Nassir, Kenneth Offit, Shuji Ogino, Salvatore Panico, Patrick S Parfrey, Rachel Pearlman, Paul DP Pharoah, Amanda I Phipps, Elizabeth A Platz, John D Potter, Ross L Prentice, Lihong Qi, Leon Raskin, Gad Rennert, Hedy S Rennert, Elio Riboli, Clemens Schafmayer, Robert E Schoen, Daniela Seminara, Mingyang Song, Yu-Ru Su, Catherine M Tangen, Stephen N Thibodeau, Duncan C Thomas, Antonia Trichopoulou, Cornelia M Ulrich, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Korbinian Weigl, Stephanie J Weinstein, Emily White, Alicja Wolk, Michael O Woods, Anna H Wu, Goncalo R Abecasis, Deborah A Nickerson, Peter C Scacheri, Anshul Kundaje, Graham Casey, Stephen B Gruber, Li Hsu, Victor Moreno, Richard B Hayes, Polly A Newcomb, Ulrike Peters
Mar 02, 2021
OBJECTIVE: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and...
CANCER GENETICS cancer susceptibility colon carcinogenesis colorectal cancer GENETIC POLYMORPHISMS Adult Age Distribution Age of Onset Aged Aged 80 and over Alleles Case-Control Studies Cecum Colon Colon Ascending Colon Descending Colon Sigmoid Colon Transverse Colonic Neoplasms Female Genetic Heterogeneity Genome-Wide Association Study Genotype Humans Male Middle Aged Polymorphism Single Nucleotide Rectal Neoplasms Risk Factors White People Young Adult
Characteristics of patients with missing information on stage
Chiara Di Girolamo, Sarah Walters, Sara Benitez Majano, Bernard Rachet, Michel P Coleman, Edmund Njeru Njagi, Melanie Morris
Sep 29, 2018
BACKGROUND: Stage is a key predictor of cancer survival. Complete cancer staging is vital for understanding outcomes at population level and monitoring the efficacy of early diagnosis initiatives. Cancer registries usually...
A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors.
Isabella Orienti, Federica Francescangeli, Maria Laura De Angelis, Katia Fecchi, Lucilla Bongiorno-Borbone, Michele Signore, Angelo Peschiaroli, Alessandra Boe, Alessandro Bruselles, Angelita Costantino, Adriana Eramo, Valentina Salvati, Giovanni Sette, Paola Contavalli, Lello Zolla, Toshihiko Oki, Toshio Kitamura, Massimo Spada, Alessandro Giuliani, Marta Baiocchi, Filippo La Torre, Gerry Melino, Marco Tartaglia, Ruggero De Maria, Ann Zeuner
Sep 10, 2019
Fenretinide is a synthetic retinoid characterized by anticancer activity in preclinical models and favorable toxicological profile, but also by a low bioavailability that hindered its clinical efficacy in former clinical trials....
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.
Zheng Xue, Daniel J Vis, Alejandra Bruna, Tonci Sustic, Sake van Wageningen, Ankita Sati Batra, Oscar M Rueda, Evert Bosdriesz, Carlos Caldas, Lodewyk FA Wessels, René Bernards
Apr 29, 2019
Activation of the mitogen-activated protein kinase (MAPK) pathway is frequent in cancer. Drug development efforts have been focused on kinases in this pathway, most notably on RAF and MEK. We show here that MEK inhibition...
Animals Benzimidazoles Breast Neoplasms Cell Line Tumor Colonic Neoplasms Drug Resistance Neoplasm Female Heterografts Humans Loss of Function Mutation MAP Kinase Kinase 4 MAP Kinase Kinase Kinase 1 MAP Kinase Signaling System Male Mice Inbred BALB C Mice Nude Mitogen-Activated Protein Kinase Kinases Prostatic Neoplasms Protein Kinase Inhibitors
A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression
KB Meyer, A-T Maia, M O'Reilly, M Ghoussaini, R Prathalingam, P Porter-Gill, S Ambs, L Prokunina-Olsson, J Carroll, BAJ Ponder
Apr 26, 2017
Alleles Base Sequence Binding Sites Breast Neoplasms Cell Line Tumor Chromosomes Human Pair 8 Colonic Neoplasms Consensus Sequence Female Gene Expression Regulation Neoplastic Genetic Loci Genetic Predisposition to Disease Genotype HCT116 Cells Humans Male Models Biological Polymorphism Single Nucleotide Prostatic Neoplasms RNA Untranslated Transcriptional Activation YY1 Transcription Factor