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Results: 60
PathoPhenoDB, linking human pathogens to their phenotypes in support of infectious disease research.
Şenay Kafkas, Marwa Abdelhakim, Yasmeen Hashish, Maxat Kulmanov, Marwa Abdellatif, Paul N Schofield, Robert Hoehndorf
Sep 06, 2019
Understanding the relationship between the pathophysiology of infectious disease, the biology of the causative agent and the development of therapeutic and diagnostic approaches is dependent on the synthesis of a wide range of...
Consanguinity and susceptibility to infectious diseases in humans.
Studies of animal populations suggest that low genetic heterozygosity is an important risk factor for infection by a diverse range of pathogens, but relatively little research has looked to see whether similar patterns exist in...
Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory.
The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines...
Genetic Engineering Immune Evasion immunological memory orthopoxviruses smallpox vaccine vaccinia virus Animals Communicable Diseases Emerging Cytokines Genetic Engineering Humans Immunity Immunogenicity Vaccine Immunologic Memory immunomodulation Inflammation Mediators smallpox smallpox vaccine vaccinia virus Viral Vaccines Zoonoses
Characterizing Emerging Canine H3 Influenza Viruses.
Luis Martinez-Sobrido, Pilar Blanco-Lobo, Laura Rodriguez, Theresa Fitzgerald, Hanyuan Zhang, Phuong Nguyen, Christopher S Anderson, Jeanne Holden-Wiltse, Sanjukta Bandyopadhyay, Aitor Nogales, Marta L DeDiego, Brian R Wasik, Benjamin L Miller, Carole Henry, Patrick C Wilson, Mark Y Sangster, John J Treanor, David J Topham, Lauren Byrd-Leotis, David A Steinhauer, Richard D Cummings, Jasmina M Luczo, Stephen M Tompkins, Kaori Sakamoto, Cheryl A Jones, John Steel, Anice C Lowen, Shamika Danzy, Hui Tao, Ashley L Fink, Sabra L Klein, Nicholas Wohlgemuth, Katherine J Fenstermacher, Farah El Najjar, Andrew Pekosz, Lauren Sauer, Mitra K Lewis, Kathryn Shaw-Saliba, Richard E Rothman, Zhen-Ying Liu, Kuan-Fu Chen, Colin R Parrish, Ian EH Voorhees, Yoshihiro Kawaoka, Gabriele Neumann, Shiho Chiba, Shufang Fan, Masato Hatta, Huihui Kong, Gongxun Zhong, Guojun Wang, Melissa B Uccellini, Adolfo García-Sastre, Daniel R Perez, Lucas M Ferreri, Sander Herfst, Mathilde Richard, Ron Fouchier, David Burke, David Pattinson, Derek J Smith, Victoria Meliopoulos, Pamela Freiden, Brandi Livingston, Bridgett Sharp, Sean Cherry, Juan Carlos Dib, Guohua Yang, Charles J Russell, Subrata Barman, Richard J Webby, Scott Krauss, Angela Danner, Karlie Woodard, Malik Peiris, RAPM Perera, MCW Chan, Elena A Govorkova, Bindumadhav M Marathe, Philippe NQ Pascua, Gavin Smith, Yao-Tsun Li, Paul G Thomas, Stacey Schultz-Cherry
Jun 12, 2020
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3...
Persistence of Imported Malaria Into the United Kingdom
BACKGROUND: The United Kingdom documented a decline of >30% in imported cases of malaria annually between 1996 and 2003; however, there are still approximately 1700 cases and 5-10 deaths each year. Prophylaxis health messages...
imported Malaria Risk Factors Adolescent Adult Age Factors Aged Aged 80 and over Child Child Preschool Communicable Diseases Imported Female Humans Infant Malaria Male Middle Aged Plasmodium Population Surveillance Retrospective Studies Risk Factors Seasons Sex Factors Travel United Kingdom Young Adult
Impact of Zika Virus Emergence in French Guiana
Claude Flamand, Sarah Bailly, Camille Fritzell, Léna Berthelot, Jessica Vanhomwegen, Henrik Salje, Juliette Paireau, Séverine Matheus, Antoine Enfissi, Sandrine Fernandes-Pellerin, Félix Djossou, Sébastien Linares, Jean-François Carod, Mirdad Kazanji, Jean-Claude Manuguerra, Simon Cauchemez, Dominique Rousset
Feb 15, 2021
BACKGROUND: Since the identification of Zika virus (ZIKV) in Brazil in May 2015, the virus has spread throughout the Americas. However, ZIKV burden in the general population in affected countries remains unknown. METHODS: We...
French Guiana Zika Virus general population survey seroprevalence study Adolescent Adult Aged Child Child Preschool Communicable Diseases Emerging Cross-Sectional Studies Female French Guiana Geography Medical Humans Male Middle Aged Population Surveillance Seroepidemiologic Studies Serologic Tests Young Adult Zika Virus Zika Virus Infection
Stepwise pathogenic evolution of Mycobacterium abscessus.
Josephine M Bryant, Karen P Brown, Sophie Burbaud, Isobel Everall, Juan M Belardinelli, Daniela Rodriguez-Rincon, Dorothy M Grogono, Chelsea M Peterson, Deepshikha Verma, Ieuan E Evans, Christopher Ruis, Aaron Weimann, Divya Arora, Sony Malhotra, Bridget Bannerman, Charlotte Passemar, Kerra Templeton, Gordon MacGregor, Kasim Jiwa, Andrew J Fisher, Tom L Blundell, Diane J Ordway, Mary Jackson, Julian Parkhill, R Andres Floto
May 05, 2021
Although almost all mycobacterial species are saprophytic environmental organisms, a few, such as Mycobacterium tuberculosis, have evolved to cause transmissible human infection. By analyzing the recent emergence and spread of...
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission
Dinesh Aggarwal, Andrew Page, Ulf Schaefer, George Savva, Richard Myers, Erik Volz, Nicholas Ellaby, Steven Platt, Natalie Groves, Eileen Gallaghar, Niamh Tumelty, Thanh Le Viet, Gareth Hughes, Cong Chen, Charlie Turner, Sophie Logan, Abbie Harrison, Sharon Peacock, Meera Chand, Ewan Harrison
Mar 28, 2022
Balancing timeliness of reporting with increasing testing probability for epidemic data.
Reporting of epidemiological data requires coordinated action by numerous agencies, across a multitude of logistical steps. Using collated and reported information to inform direct interventions can be challenging due to...
Building an integrated serosurveillance platform to inform public health interventions
Kirsten E Wiens, Barbara Jauregui, Benjamin F Arnold, Kathryn Banke, Djibril Wade, Kyla Hayford, Adriana Costero-Saint Denis, Robert H Hall, Henrik Salje, Isabel Rodriguez-Barraquer, Andrew S Azman, Guy Vernet, Daniel T Leung
Nov 06, 2022
The use of biomarkers to measure immune responses in serum is crucial for understanding population-level exposure and susceptibility to human pathogens. Advances in sample collection, multiplex testing, and computational...
Published by: PLoS neglected tropical diseases
Bacterial Membrane Mimetics
Sagar S Arya, Nada K Morsy, Deema K Islayem, Sarah A Alkhatib, Charalampos Pitsalidis, Anna-Maria Pappa
Feb 21, 2023
PHI-base
Martin Urban, Alayne Cuzick, James Seager, Valerie Wood, Kim Rutherford, Shilpa Yagwakote Venkatesh, Nishadi De Silva, Manuel Carbajo Martinez, Helder Pedro, Andy D Yates, Keywan Hassani-Pak, Kim E Hammond-Kosack
Oct 11, 2019
The pathogen-host interactions database (PHI-base) is available at www.phi-base.org. PHI-base contains expertly curated molecular and biological information on genes proven to affect the outcome of pathogen-host interactions...
Emergence of phylogenetically diverse and fluoroquinolone resistant Salmonella Enteritidis as a cause of invasive nontyphoidal Salmonella disease in Ghana.
Cassandra Aldrich, Hassan Hartman, Nicholas Feasey, Marie Anne Chattaway, Denise Dekker, Hassan M Al-Emran, Lesley Larkin, Jacquelyn McCormick, Nimako Sarpong, Simon Le Hello, Yaw Adu-Sarkodie, Ursula Panzner, Se Eun Park, Justin Im, Florian Marks, Jürgen May, Timothy J Dallman, Daniel Eibach
Nov 26, 2019
BACKGROUND: Salmonella enterica serovar Enteritidis is a cause of both poultry- and egg-associated enterocolitis globally and bloodstream-invasive nontyphoidal Salmonella (iNTS) disease in sub-Saharan Africa (sSA). Distinct...
Adolescent Animals Anti-Bacterial Agents Child Child Preschool Communicable Diseases Emerging Enterocolitis Female Fluoroquinolones genetic variation Genotype Ghana Humans Infant Male Microbial Sensitivity Tests molecular epidemiology Phylogeny Poultry Salmonella Infections Salmonella Infections Animal Salmonella enteritidis whole genome sequencing
Estimating the health impact of vaccination against ten pathogens in 98 low-income and middle-income countries from 2000 to 2030
Xiang Li, Christinah Mukandavire, Zulma M Cucunubá, Susy Echeverria Londono, Kaja Abbas, Hannah E Clapham, Mark Jit, Hope L Johnson, Timos Papadopoulos, Emilia Vynnycky, Marc Brisson, Emily D Carter, Andrew Clark, Margaret J de Villiers, Kirsten Eilertson, Matthew J Ferrari, Ivane Gamkrelidze, Katy AM Gaythorpe, Nicholas C Grassly, Timothy B Hallett, Wes Hinsley, Michael L Jackson, Kévin Jean, Andromachi Karachaliou, Petra Klepac, Justin Lessler, Xi Li, Sean M Moore, Shevanthi Nayagam, Duy Manh Nguyen, Homie Razavi, Devin Razavi-Shearer, Stephen Resch, Colin Sanderson, Steven Sweet, Stephen Sy, Yvonne Tam, Hira Tanvir, Quan Minh Tran, Caroline L Trotter, Shaun Truelove, Kevin van Zandvoort, Stéphane Verguet, Neff Walker, Amy Winter, Kim Woodruff, Neil M Ferguson, Tini Garske, Vaccine Impact Modelling Consortium
Feb 01, 2021
BACKGROUND: The past two decades have seen expansion of childhood vaccination programmes in low-income and middle-income countries (LMICs). We quantify the health impact of these programmes by estimating the deaths and...
Four key challenges in infectious disease modelling using data from multiple sources.
Daniela De Angelis, Anne M Presanis, Paul J Birrell, Gianpaolo Scalia Tomba, Thomas House
Jul 11, 2018
Public health-related decision-making on policies aimed at controlling epidemics is increasingly evidence-based, exploiting multiple sources of data. Policy makers rely on complex models that are required to be robust...
Design and implementation of multiplexed amplicon sequencing panels to serve genomic epidemiology of infectious disease
Emily LaVerriere, Philipp Schwabl, Manuela Carrasquilla, Aimee R Taylor, Zachary M Johnson, Meg Shieh, Ruchit Panchal, Timothy J Straub, Rebecca Kuzma, Sean Watson, Caroline O Buckee, Carolina M Andrade, Silvia Portugal, Peter D Crompton, Boubacar Traore, Julian C Rayner, Vladimir Corredor, Kashana James, Horace Cox, Angela M Early, Bronwyn L MacInnis, Daniel E Neafsey
May 09, 2022
Deep sequencing approach for investigating infectious agents causing fever.
TN Susilawati, AR Jex, C Cantacessi, M Pearson, S Navarro, A Susianto, AC Loukas, WJH McBride
Apr 22, 2016
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