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Results: 23
Are biologics more effective than corticosteroids for intra‐articular treatment of osteoarthritis?
Summary: Intra‐articular corticosteroids are an effective treatment for equine osteoarthritis, however, there is increasing evidence for the effectiveness of other treatments such as biologics. Whilst current evidence does...
Patient-centred outcomes of imaging tests
Matthew J Thompson, Monica Zigman Suchsland, Victoria Hardy, Danielle C Lavallee, Sally Lord, Emily Beth Devine, Jeffrey G Jarvik, Steven Findlay, Thomas A Trikalinos, Fiona M Walter, Roger Chou, Beverly B Green, Karen J Wernli, Annette L Fitzpatrick, Patrick M Bossuyt
Apr 28, 2022
BACKGROUND: Imaging tests are one of the most frequently used diagnostic modalities in healthcare, but the benefits of their direct impacts on clinical decision-making have been countered by concerns that they can be overused....
The Stroke Prevention Programme
Background
The management of cardiovascular (CV) risk factors in community populations is suboptimal. The aim of this programme was to explore the role of three approaches [use of a ‘polypill’; self-management of...
Comparative Effectiveness Research Health Services Hypertension Clinical Trials and Supportive Activities Prevention Cost Effectiveness Research Cardiovascular Brain Disorders stroke Clinical Research 7 Management of diseases and conditions 7.3 Management and decision making 7.1 Individual care needs stroke Cardiovascular 3 Good Health and Well Being
Standard versus simplified radiofrequency ablation protocol for Barrett's esophagus
Wei Keith Tan, Krish Ragunath, Jonathan R White, Jose Santiago, Jacobo Ortiz Fernandez-Sordo, Mirela Pana, Bincy Alias, Andreas V Hadjinicolaou, Vijay Sujendran, Massimiliano di Pietro
Apr 15, 2019
What is the optimal management of potentially resectable stage III-N2 NSCLC? Results of a fixed-effects network meta-analysis and economic modelling.
Matthew Evison, Ross Maconachie, Toby Mercer, Caitlin H Daly, Nicky J Welton, Shahzeena Aslam, Doug West, Neal Navani
Apr 17, 2023
INTRODUCTION: There is a critical need to understand the optimal treatment regimen in patients with potentially resectable stage III-N2 nonsmall cell lung cancer (NSCLC). METHODS: A systematic review of randomised controlled...
Outpatient services and primary care
Eleanor Winpenny, Céline Miani, Emma Pitchforth, Sarah Ball, Ellen Nolte, Sarah King, Joanne Greenhalgh, Martin Roland
May 17, 2016
Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps
Carl Philpott, Steffi Le Conte, David Beard, Jonathan Cook, William Sones, Steve Morris, Caroline S Clarke, Mike Thomas, Paul Little, Jane Vennik, Valerie Lund, Helen Blackshaw, Anne Schilder, Stephen Durham, Spiros Denaxas, James Carpenter, James Boardman, Claire Hopkins, MACRO programme team
Feb 24, 2020
BACKGROUND: Chronic rhinosinusitis (CRS) is a common source of ill health; 11% of UK adults reported CRS symptoms in a worldwide population study. Guidelines are conflicting regarding whether antibiotics should be included in...
Chronic rhinosinusitis clarithromycin endoscopic sinus surgery randomised controlled trial Administration Oral Anti-Bacterial Agents Chronic Disease Clarithromycin Comparative Effectiveness Research Drug Administration Schedule endoscopy Female Humans Male Multicenter Studies as Topic Nasal Polyps Nasal Surgical Procedures Pilot Projects Randomized Controlled Trials as Topic Rhinitis Sinusitis Time Factors Treatment Outcome United Kingdom
General practitioners' perceptions of the effectiveness of medical interventions
BACKGROUND: Many interventions shown to be effective through clinical trials are not readily implemented in clinical practice. Unfortunately, little is known regarding how clinicians construct their perceptions of the...
1117 Public Health and Health Services 1103 Clinical Sciences Health services & systems Health Services Research Smoking and Health Cardiovascular Tobacco Clinical Research Comparative Effectiveness Research Brain Disorders Heart Disease Prevention Behavioral and Social Science Mind and Body Clinical Trials and Supportive Activities Cardiovascular Cancer
A school-based, peer-led programme to increase physical activity among 13- to 14-year-old adolescents
Kirsten L Corder, Helen E Brown, Caroline HD Croxson, Stephanie T Jong, Stephen J Sharp, Anna Vignoles, Paul O Wilkinson, Edward Cf Wilson, Esther Mf van Sluijs
May 31, 2021
Background
Adolescent physical activity levels are low and are associated with rising disease risk and social disadvantage. The Get Others Active (GoActive) intervention was co-designed with adolescents and teachers to...
Comparative Effectiveness Research Clinical Research Prevention Behavioral and Social Science Pediatric Clinical Trials and Supportive Activities 3 Prevention of disease and conditions and promotion of well-being 3.1 Primary prevention interventions to modify behaviours or promote wellbeing stroke Cancer Cardiovascular
Intensive therapy for moderate established rheumatoid arthritis
David L Scott, Fowzia Ibrahim, Harry Hill, Brian Tom, Louise Prothero, Rhiannon R Baggott, Ailsa Bosworth, James B Galloway, Sofia Georgopoulou, Naomi Martin, Isabel Neatrour, Elena Nikiphorou, Jackie Sturt, Allan Wailoo, Frances MK Williams, Ruth Williams, Heidi Lempp
Apr 15, 2021
Variation in Structure and Process of Care in Traumatic Brain Injury
Maryse C Cnossen, Suzanne Polinder, Hester F Lingsma, Andrew IR Maas, David Menon, Ewout W Steyerberg, CENTER-TBI Investigators and Participants
Jun 19, 2018
INTRODUCTION: The strength of evidence underpinning care and treatment recommendations in traumatic brain injury (TBI) is low. Comparative effectiveness research (CER) has been proposed as a framework to provide evidence for...
Controlling hypertension immediately post stroke
BACKGROUND: Elevated blood pressure (BP) levels are common following acute stroke. However, there is considerable uncertainty if and when antihypertensive therapy should be initiated. METHOD: Economic evaluation alongside a...
Adjusting for confounding by indication in observational studies
Maryse C Cnossen, Thomas A van Essen, Iris E Ceyisakar, Suzanne Polinder, Teuntje M Andriessen, Joukje van der Naalt, Iain Haitsma, Janneke Horn, Gaby Franschman, Pieter E Vos, Wilco C Peul, David K Menon, Andrew IR Maas, Ewout W Steyerberg, Hester F Lingsma
Sep 20, 2018
INTRODUCTION: Observational studies of interventions are at risk for confounding by indication. The objective of the current study was to define the circumstances for the validity of methods to adjust for confounding by...
Screening of healthcare workers for tuberculosis
Methods for determining cost-effectiveness of different treatments are well established, unlike appraisal of non-drug interventions, including novel diagnostics and biomarkers.
Variation in general supportive and preventive intensive care management of traumatic brain injury
Jilske A Huijben, Victor Volovici, Maryse C Cnossen, Iain K Haitsma, Nino Stocchetti, Andrew IR Maas, David K Menon, Ari Ercole, Giuseppe Citerio, David Nelson, Suzanne Polinder, Ewout W Steyerberg, Hester F Lingsma, Mathieu van der Jagt, CENTER-TBI Investigators and Participants
May 02, 2018
BACKGROUND: General supportive and preventive measures in the intensive care management of traumatic brain injury (TBI) aim to prevent or limit secondary brain injury and optimize recovery. The aim of this survey was to assess...
blood pressure Europe Fever Glucose intensive care unit Nutrition Seizure Survey Traumatic brain injury ventilation Adult Brain Injuries Traumatic Comparative Effectiveness Research Europe Female Humans Intensive Care Units Male Program Evaluation Quality of Health Care Surveys and Questionnaires Trauma Centers
'Decision support system (DSS) for prevention of cardiovascular disease (CVD) among hypertensive (HTN) patients in Andhra Pradesh, India'--a cluster randomised community intervention trial.
Clinical and cost-effectiveness analysis of an open label, single-centre, randomised trial of spinal cord stimulation (SCS) versus percutaneous myocardial laser revascularisation (PMR) in patients with refractory angina pectoris
MT Dyer, KA Goldsmith, SN Khan, LD Sharples, C Freeman, I Hardy, MJ Buxton, PM Schofield
Jun 16, 2011
Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury
MC Cnossen, JA Huijben, M van der Jagt, V Volovici, T van Essen, S Polinder, D Nelson, A Ercole, N Stocchetti, G Citerio, WC Peul, AIR Maas, D Menon, EW Steyerberg, HF Ligsma
Dec 07, 2017
Background: No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that centers and practitioners individually balance potential...
The multimorbidity collaborative medication review and decision making (MyComrade) study
Collette Kirwan, Lisa Hynes, Nigel Hart, Sarah Mulligan, Claire Leathem, Laura McQuillan, Marina Maxwell, Emma Carr, Kevin Roche, Scott Walkin, Caroline McCarthy, Colin Bradley, Molly Byrne, Susan M Smith, Carmel Hughes, Maura Corry, Patricia M Kearney, Geraldine McCarthy, Margaret Cupples, Paddy Gillespie, Anna Hobbins, John Newell, Liam Glynn, Davood Roshan, Carol Sinnott, Andrew W Murphy
Nov 04, 2022
BACKGROUND: While international guidelines recommend medication reviews as part of the management of multimorbidity, evidence on how to implement reviews in practice in primary care is lacking. The MyComrade (MultimorbiditY...
IMPRoving Outcomes for children exposed to domestic ViolencE (IMPROVE)
Background Exposure to domestic violence and abuse (DVA) during childhood and adolescence increases the risk of negative outcomes across the...
Emma Howarth, Theresa HM Moore, Nicky J Welton, Natalia Lewis, Nicky Stanley, Harriet MacMillan, Alison Shaw, Marianne Hester, Peter Bryden, Gene Feder
Feb 17, 2020
Clinical Research Health Services Behavioral and Social Science Pediatric Mental Health Comparative Effectiveness Research 3.1 Primary prevention interventions to modify behaviours or promote wellbeing 8 Health and social care services research 6 Evaluation of treatments and therapeutic interventions 6.6 Psychological and behavioural 8.1 Organisation and delivery of services 3 Prevention of disease and conditions and promotion of well-being Mental Health 16 Peace Justice and Strong Institutions
Self-Monitoring and Management of Blood Pressure in Patients with Stroke or TIA
Lois G Kim, Edward Cf Wilson, William J Davison, Allan B Clark, Phyo K Myint, John F Potter
Jan 31, 2020
Patient-centred outcomes of imaging tests
Matthew J Thompson, Monica Zigman Suchsland, Victoria Hardy, Danielle C Lavallee, Sally Lord, Emily Beth Devine, Jeffrey G Jarvik, Steven Findlay, Thomas A Trikalinos, Fiona Walter, Roger Chou, Beverly B Green, Karen J Wernli, Annette L Fitzpatrick, Patrick M Bossuyt
Oct 11, 2021
BACKGROUND: Imaging tests are one of the most frequently used diagnostic modalities in healthcare, but the benefits of their direct impacts on clinical decision-making have been countered by concerns that they can be overused....