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BACKGROUND: Clinical trials and other studies commonly assess the effectiveness of an intervention through the use of responder-based endpoints. These classify patients based on whether they meet a number of criteria which often...

Augmented binary method Composite endpoint Efficiency Responder analysis statistical analysis Clinical Trials as Topic Data Interpretation Statistical Endpoint Determination Humans Outcome Assessment Health Care

Composite endpoints that combine multiple outcomes on different scales are common in clinical trials, particularly in chronic conditions. In many of these cases, patients will have to cross a predefined responder threshold in...

ARTICLES Composite endpoint latent variable model Responder analysis Systemic Lupus Erythematosus

Abstract: Background: Clinical trials and other studies commonly assess the effectiveness of an intervention through the use of responder-based endpoints. These classify patients based on whether they meet a number of criteria...

Research Augmented binary method Composite endpoint Efficiency Responder analysis statistical analysis

BACKGROUND: Despite progress that has been made in the treatment of many immune-mediated inflammatory diseases (IMIDs), there remains a need for improved treatments. Randomised controlled trials (RCTs) provide the highest form...

adaptive design Basket design Bayesian design Composite endpoint high-dimensional data Routinely collected data SMART trial Umbrella design

Composite endpoints that combine multiple outcomes on different scales are common in clinical trials, particularly in chronic conditions. In many of these cases, patients will have to cross a predefined responder threshold in...

Composite endpoint latent variable model Responder analysis Systemic Lupus Erythematosus Humans Logistic Models Lupus Erythematosus Systemic Research Design Sample Size Treatment Outcome

Abstract: Background: Clinical trials and other studies commonly assess the effectiveness of an intervention through the use of responder-based endpoints. These classify patients based on whether they meet a number of criteria...

Research Augmented binary method Composite endpoint Efficiency Responder analysis statistical analysis

Abstract: Background: Despite progress that has been made in the treatment of many immune-mediated inflammatory diseases (IMIDs), there remains a need for improved treatments. Randomised controlled trials (RCTs) provide the...

RESEARCH ARTICLE Epidemiology and public health adaptive design Basket design Bayesian design Composite endpoint high-dimensional data Routinely collected data SMART trial Umbrella design