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A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria.
BACKGROUND: Nearly half of the world's population (3.2 billion people) were at risk of malaria in 2015, and resistance to current therapies is a major concern. While the standard of care includes drug combinations, there is a...
Compound combination modelling Machine Learning Malaria Synergistic anti-malaria compound combinations Synergy prediction Transcriptional drug repositioning Antimalarials Drug Combinations Drug Discovery Drug Repositioning Drug Synergism Humans Machine Learning Malaria Falciparum Plasmodium falciparum Protozoan Proteins