Search
Results: 424
Hybridization of DNA by sequential immobilization of oligonucleotides at the air-water interface
The hybridization of DNA by sequential electrostatic and hydrogen-bonding immobilization of single-stranded complementary oligonucleotides at the air-water interface with cationic Langmuir monolayers is demonstrated. The...
Monolayers Interfaces Genetics molecules hybridization Analytical, Diagnostic and Therapeutic Techniques and Equipment Biochemical and Biomolecular Engineering Biology and Biomimetic Materials biomaterials Biomedical Biomedical Engineering and Bioengineering Bioresource and Agricultural Engineering Biotechnology Business Administration, Management, and Operations Computational Biology Food Biotechnology Food Microbiology food processing health economics Medical Biotechnology Medical Molecular Biology Medical Pharmacology Molecular Biology Molecular, Cellular, and Tissue Engineering Molecular, Genetic, and Biochemical Nutrition Molecular genetics nanomedicine Nanoscience and Nanotechnology Nanotechnology Nanotechnology Fabrication Pharmacy and Pharmaceutical Sciences
Published by: Harrisburg University of Science and Technology
ANION INDUCED BLUE TO PURPLE TRANSITION IN BACTERIORHODOPSIN
Purple membrane (PM, ?" role="presentation">?max" role="presentation">max 570 nm) of H. halobium on treatment with sulphuric acid changes its colour to blue (?" role="presentation">?max" role="presentation">max 608 nm). The...
H. halobium Fluorescence circular dichroic molecular mechanism Analytical, Diagnostic and Therapeutic Techniques and Equipment Biochemical and Biomolecular Engineering Biology and Biomimetic Materials biomaterials Biomedical Biomedical Engineering and Bioengineering Bioresource and Agricultural Engineering Biotechnology Business Administration, Management, and Operations Computational Biology Food Biotechnology Food Microbiology food processing health economics Medical Biotechnology Medical Molecular Biology Medical Pharmacology Molecular Biology Molecular, Cellular, and Tissue Engineering Molecular, Genetic, and Biochemical Nutrition Molecular genetics nanomedicine Nanoscience and Nanotechnology Nanotechnology Nanotechnology Fabrication Pharmacy and Pharmaceutical Sciences
Published by: Harrisburg University of Science and Technology
Sum Rate of MISO Neuro-Spike Communication Channel With Constant Spiking Threshold.
Communication among neurons, known as neuro-spike communication, is the most promising technique for realization of a bio-inspired nanoscale communication paradigm to achieve biocompatible nanonetworks. In neuro-spike...
Genome-wide Estrogen Receptor-α activation is sustained, not cyclical.
Estrogen Receptor-alpha (ER) drives 75% of breast cancers. Stimulation of the ER by estra-2-diol forms a transcriptionally-active chromatin-bound complex. Previous studies reported that ER binding follows a cyclical pattern....
Estrogen estrogen receptor MCF7 Breast Cancer Chromosomes Computational Biology endocrine Gene Expression human Systems Biology Base Sequence Binding Sites Estradiol Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Genome Human Genome-Wide Association Study Humans MCF-7 Cells Neoplasm Proteins Promoter Regions Genetic Protein Binding Receptors CXCR Signal Transduction Sorting Nexins Trefoil Factor-1
Switchable slow cellular conductances determine robustness and tunability of network states.
Neuronal information processing is regulated by fast and localized fluctuations of brain states. Brain states reliably switch between distinct spatiotemporal signatures at a network scale even though they are composed of...
PAGA
F Alexander Wolf, Fiona K Hamey, Mireya Plass, Jordi Solana, Joakim S Dahlin, Berthold Göttgens, Nikolaus Rajewsky, Lukas Simon, Fabian J Theis
Feb 18, 2019
Accurate mitochondrial DNA sequencing using off-target reads provides a single test to identify pathogenic point mutations.
Helen R Griffin, Angela Pyle, Emma L Blakely, Charlotte L Alston, Jennifer Duff, Gavin Hudson, Rita Horvath, Ian J Wilson, Mauro Santibanez-Koref, Robert W Taylor, Patrick F Chinnery
Mar 07, 2019
PURPOSE: Mitochondrial disorders are a common cause of inherited metabolic disease and can be due to mutations affecting mitochondrial DNA or nuclear DNA. The current diagnostic approach involves the targeted resequencing of...
How modeling can reconcile apparently discrepant experimental results
Midbrain dopaminergic neurons are endowed with endogenous slow pacemaking properties. In recent years, many different groups have studied the basis for this phenomenon, often with conflicting conclusions. In particular, the role...
DeepSynergy
Kristina Preuer, Richard PI Lewis, Sepp Hochreiter, Andreas Bender, Krishna C Bulusu, Günter Klambauer
Nov 05, 2018
MOTIVATION: While drug combination therapies are a well-established concept in cancer treatment, identifying novel synergistic combinations is challenging due to the size of combinatorial space. However, computational approaches...
TransRate
TransRate is a tool for reference-free quality assessment of de novo transcriptome assemblies. Using only the sequenced reads and the assembly as input, we show that multiple common artifacts of de novo transcriptome assembly...
Tissue-specific transcriptomes of Anisakis simplex (sensu stricto) and Anisakis pegreffii reveal potential molecular mechanisms involved in pathogenicity.
Serena Cavallero, Fabrizio Lombardo, Xiaopei Su, Marco Salvemini, Cinzia Cantacessi, Stefano D'Amelio
Feb 05, 2018
Background: Larval stages of the sibling species of parasitic nematodes Anisakis simplex sensu stricto (AS) and Anisakis pegreffii (AP) are responsible for a fish-borne zoonosis, known as anisakiasis, that humans acquire via the...
Computational prediction and design for creating iteratively larger heterospecific coiled coil sets
A major biochemical goal is the ability to mimic nature in engineering highly specific protein-protein interactions. We previously devised a computational interactome screen to identify eight peptides that form four...
Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.
Morgan Oatley, Özge Vargel Bölükbası, Valentine Svensson, Maya Shvartsman, Kerstin Ganter, Katharina Zirngibl, Polina V Pavlovich, Vladislava Milchevskaya, Vladimira Foteva, Kedar N Natarajan, Bianka Baying, Vladimir Benes, Kiran R Patil, Sarah A Teichmann, Christophe Lancrin
Mar 05, 2020
The endothelial to haematopoietic transition (EHT) is the process whereby haemogenic endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs). The intermediary steps of this process are unclear, in...
Animals Aorta arteries Biomarkers Cell Cycle Citric Acid Cycle Computational Biology Core Binding Factor Alpha 2 Subunit Down-Regulation Endothelium Glycolysis Gonads Hematopoiesis Hematopoietic Stem Cells Hyaluronan Receptors Hyaluronic Acid Mesonephros Mice Mice Inbred C57BL Mice Knockout Transcriptome Transforming Growth Factor beta
Comparative Genomics
Duncan T Odom
Jan 31, 2020
Using a common analysis pipeline to compare data from three major lineages of complex eukaryotes reveals that transcription seems to evolve at a common rate.
A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications.
RNA sequencing (RNA-seq) is a genomic approach for the detection and quantitative analysis of messenger RNA molecules in a biological sample and is useful for studying cellular responses. RNA-seq has fueled much discovery and...
Improved characterisation of MRSA transmission using within-host bacterial sequence diversity.
Matthew D Hall, Matthew TG Holden, Pramot Srisomang, Weera Mahavanakul, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Kay Fountain, Julian Parkhill, Emma K Nickerson, Sharon J Peacock, Christophe Fraser
Nov 04, 2019
MRSA EPIDEMIOLOGY Global Health hospital infections human molecular epidemiology Adult Child Computational Biology Cross Infection DNA Bacterial Disease Outbreaks genetic variation Genome Bacterial Humans Methicillin-Resistant Staphylococcus aureus Phylogeny Polymorphism Single Nucleotide Staphylococcal Infections Thailand whole genome sequencing
Ontology-based prediction of cancer driver genes.
Sara Althubaiti, Andreas Karwath, Ashraf Dallol, Adeeb Noor, Shadi Salem Alkhayyat, Rolina Alwassia, Katsuhiko Mineta, Takashi Gojobori, Andrew D Beggs, Paul N Schofield, Georgios V Gkoutos, Robert Hoehndorf
Nov 27, 2019
Identifying and distinguishing cancer driver genes among thousands of candidate mutations remains a major challenge. Accurate identification of driver genes and driver mutations is critical for advancing cancer research and...
A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV).
Samiha S Shaikh, Ya-Chun Chen, Sally-Anne Halsall, Michael S Nahorski, Kiyoyuki Omoto, Gareth T Young, Anne Phelan, Christopher Geoffrey Woods
Nov 28, 2016
CIPA NGF TRKA neuropathy Pain Alleles Cell Line Computational Biology DNA Mutational Analysis Gene Order Genetic Association Studies Genetic Loci Genetic Predisposition to Disease Genotype Glycosylation Hereditary Sensory and Autonomic Neuropathies Humans Molecular Imaging Mutation Missense Neurites Phospholipase C gamma Phosphorylation Protein Binding Protein Interaction Domains and Motifs Receptor trkA Recombinant Fusion Proteins Sequence Analysis DNA Signal Transduction
Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability.
Detelina Grozeva, Keren Carss, Olivera Spasic-Boskovic, Maria-Isabel Tejada, Jozef Gecz, Marie Shaw, Mark Corbett, Eric Haan, Elizabeth Thompson, Kathryn Friend, Zaamin Hussain, Anna Hackett, Michael Field, Alessandra Renieri, Roger Stevenson, Charles Schwartz, James AB Floyd, Jamie Bentham, Catherine Cosgrove, Bernard Keavney, Shoumo Bhattacharya, Italian X-linked Mental Retardation Project, UK10K consortium, GOLD Consortium, Matthew Hurles, F Lucy Raymond
Sep 15, 2015
Mendelian disease developmental delay Intellectual Disability next-generation sequencing Alleles Cohort Studies Computational Biology Female Genetic Association Studies High-Throughput Nucleotide Sequencing Humans Inheritance Patterns Intellectual Disability Male Mutation Polymorphism Single Nucleotide
|
|< |
< |
1 |