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Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.
Philip C Schouten, Anita Grigoriadis, Thomas Kuilman, Hasan Mirza, Johnathan A Watkins, Saskia A Cooke, Ewald van Dyk, Tesa M Severson, Oscar M Rueda, Marlous Hoogstraat, Caroline VM Verhagen, Rachael Natrajan, Suet-Feung Chin, Esther H Lips, Janneke Kruizinga, Arno Velds, Marja Nieuwland, Ron M Kerkhoven, Oscar Krijgsman, Conchita Vens, Daniel Peeper, Petra M Nederlof, Carlos Caldas, Andrew N Tutt, Lodewyk F Wessels, Sabine C Linn
Nov 09, 2017
Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be 'BRCA1-like' or 'non-BRCA1-like', which refers to resembling a BRCA1-mutated...