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Results: 73
Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease.
Brian A Ference, John JP Kastelein, Kausik K Ray, Henry N Ginsberg, M John Chapman, Chris J Packard, Ulrich Laufs, Clare Oliver-Williams, Angela M Wood, Adam S Butterworth, Emanuele Di Angelantonio, John Danesh, Stephen J Nicholls, Deepak L Bhatt, Marc S Sabatine, Alberico L Catapano
Feb 11, 2019
Apolipoproteins B Case-Control Studies Cholesterol LDL Coronary Disease Female Genetic Predisposition to Disease genetic variation Humans Lipoprotein Lipase Loss of Function Mutation Male Mendelian Randomization Analysis Metabolic Networks and Pathways Middle Aged Prospective Studies Receptors LDL Risk Factors Triglycerides
The versatility of multi-state models for the analysis of longitudinal data with unobservable features.
Multi-state models provide a convenient statistical framework for a wide variety of medical applications characterized by multiple events and longitudinal data. We illustrate this through four examples. The potential value of...
Plaque Structural Stress Estimations Improve Prediction of Future Major Adverse Cardiovascular Events After Intracoronary Imaging.
Adam J Brown, Zhongzhao Teng, Patrick A Calvert, Nikil K Rajani, Orla Hennessy, Nitesh Nerlekar, Daniel R Obaid, Charis Costopoulos, Yuan Huang, Stephen P Hoole, Martin Goddard, Nick EJ West, Jonathan H Gillard, Martin R Bennett
Jun 09, 2016
Atherosclerosis Autopsy Coronary Disease Myocardial Infarction Prospective Studies Acute Coronary Syndrome Aged Angina Stable Coronary Artery Disease Coronary Vessels Disease-Free Survival Female Fibrosis Humans Kaplan-Meier Estimate Male Middle Aged Necrosis Percutaneous Coronary Intervention Plaque Atherosclerotic Predictive Value of Tests Proportional Hazards Models Prospective Studies Risk Factors Rupture Spontaneous Severity of Illness Index Stress Mechanical Time Factors Treatment Outcome Ultrasonography Interventional Vascular Calcification
Lipoprotein(a) in Alzheimer, Atherosclerotic, Cerebrovascular, Thrombotic, and Valvular Disease
Susanna C Larsson, Dipender Gill, Amy M Mason, Tao Jiang, Magnus Bäck, Adam S Butterworth, Stephen Burgess
Jun 19, 2020
Alzheimer Disease Mendelian Randomization Analysis Atherosclerosis Heart Valve Diseases lipoprotein(a) stroke Alzheimer Disease Causality Cerebrovascular Disorders Coronary Disease Dementia Vascular Heart Valve Diseases Humans lipoprotein(a) Mendelian Randomization Analysis Odds Ratio Polymorphism Single Nucleotide Thrombosis White People
Genetic susceptibility, screen-based sedentary activities and incidence of coronary heart disease.
Youngwon Kim, Shiu Lun Au Yeung, Stephen J Sharp, Mengyao Wang, Haeyoon Jang, Shan Luo, Soren Brage, Katrien Wijndaele
Jun 29, 2022
Longitudinal associations between marine omega-3 supplement users and Coronary Heart Disease in a UK population-based cohort
Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids.
Katherine E Beaney, Jackie A Cooper, Stela McLachlan, S Goya Wannamethee, Barbara J Jefferis, Peter Whincup, Yoav Ben-Shlomo, Jacqueline F Price, Meena Kumari, Andrew Wong, Ken Ong, Rebecca Hardy, Diana Kuh, Mika Kivimaki, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Fotios Drenos, Steve E Humphries, UCLEB Consortium
Sep 29, 2016
AIMS: An intergenic locus on chromosome 1 (lead SNP rs10911021) was previously associated with coronary heart disease (CHD) in type 2 diabetes (T2D). Using data from the UCLEB consortium we investigated the relationship between...
coronary heart disease genetic risk HDL-cholesterol Metabolomics Aged Amino Acids Biomarkers Cholesterol HDL Chromosomes Human Pair 1 Coronary Disease DNA Intergenic Diabetes mellitus Type 2 Down-Regulation Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease High-Throughput Screening Assays Humans Magnetic Resonance Spectroscopy Male Metabolomics Middle Aged Particle Size Phenotype Polymorphism Single Nucleotide Protective factors Risk Assessment Risk Factors
Multilevel models for cost-effectiveness analyses that use cluster randomised trial data
Edmond S-W Ng, Karla Diaz-Ordaz, Richard Grieve, Richard M Nixon, Simon G Thompson, James R Carpenter
Nov 16, 2017
Multilevel models provide a flexible modelling framework for cost-effectiveness analyses that use cluster randomised trial data. However, there is a lack of guidance on how to choose the most appropriate multilevel models. This...
Whole grain cereals for the primary or secondary prevention of cardiovascular disease.
Sarah Am Kelly, Louise Hartley, Emma Loveman, Jill L Colquitt, Helen M Jones, Lena Al-Khudairy, Christine Clar, Roberta Germanò, Hannah R Lunn, Gary Frost, Karen Rees
Apr 10, 2018
BACKGROUND: There is evidence from observational studies that whole grains can have a beneficial effect on risk for cardiovascular disease (CVD). Earlier versions of this review found mainly short-term intervention studies....
Contextualizing selection bias in Mendelian randomization
Genomic prediction of coronary heart disease
Gad Abraham, Aki S Havulinna, Oneil G Bhalala, Sean G Byars, Alysha M De Livera, Laxman Yetukuri, Emmi Tikkanen, Markus Perola, Heribert Schunkert, Eric J Sijbrands, Aarno Palotie, Nilesh J Samani, Veikko Salomaa, Samuli Ripatti, Michael Inouye
Sep 05, 2019
Shared mechanisms between coronary heart disease and depression
Golam M Khandaker, Verena Zuber, Jessica MB Rees, Livia Carvalho, Amy M Mason, Christopher N Foley, Apostolos Gkatzionis, Peter B Jones, Stephen Burgess
Feb 19, 2019
While comorbidity between coronary heart disease (CHD) and depression is evident, it is unclear whether the two diseases have shared underlying mechanisms. We performed a range of analyses in 367,703 unrelated middle-aged...
Associations of genetically predicted fatty acid levels across the phenome
Loukas Zagkos, Marie-Joe Dib, Rui Pinto, Dipender Gill, Fotios Koskeridis, Fotios Drenos, Georgios Markozannes, Paul Elliott, Verena Zuber, Kostas Tsilidis, Abbas Dehghan, Ioanna Tzoulaki
Jan 28, 2023
BACKGROUND: Fatty acids are important dietary factors that have been extensively studied for their implication in health and disease. Evidence from epidemiological studies and randomised controlled trials on their role in...
Predicting 10-year stroke mortality
Weronika A Szlachetka, Tiberiu A Pana, Mamas A Mamas, Joao H Bettencourt-Silva, Anthony K Metcalf, John F Potter, David J McLernon, Phyo K Myint
Jun 07, 2022
Predicting long-term stroke mortality is a clinically important and unmet need. We aimed to develop and internally validate a 10-year ischaemic stroke mortality prediction score. In this UK cohort study, 10,366 patients with...
Cerebrovascular disease Ischaemic stroke long-term mortality Prediction score Prognosis Aged Aged 80 and over Atrial fibrillation Brain Ischemia Cohort Studies Coronary Disease Female Heart Failure Humans Hypertension ischemic stroke Male Nomograms peripheral vascular diseases Pulmonary Disease Chronic Obstructive Risk Factors stroke
Cardiovascular Risk Factors Associated With Venous Thromboembolism.
John Gregson, Stephen Kaptoge, Thomas Bolton, Lisa Pennells, Peter Willeit, Stephen Burgess, Steven Bell, Michael Sweeting, Eric B Rimm, Christopher Kabrhel, Bengt Zöller, Gerd Assmann, Vilmundur Gudnason, Aaron R Folsom, Volker Arndt, Astrid Fletcher, Paul E Norman, Børge G Nordestgaard, Akihiko Kitamura, Bakhtawar K Mahmoodi, Peter H Whincup, Matthew Knuiman, Veikko Salomaa, Christa Meisinger, Wolfgang Koenig, Maryam Kavousi, Henry Völzke, Jackie A Cooper, Toshiharu Ninomiya, Edoardo Casiglia, Beatriz Rodriguez, Yoav Ben-Shlomo, Jean-Pierre Després, Leon Simons, Elizabeth Barrett-Connor, Cecilia Björkelund, Marlene Notdurfter, Daan Kromhout, Jackie Price, Susan E Sutherland, Johan Sundström, Jussi Kauhanen, John Gallacher, Joline WJ Beulens, Rachel Dankner, Cyrus Cooper, Simona Giampaoli, Jason F Deen, Agustín Gómez de la Cámara, Lewis H Kuller, Annika Rosengren, Peter J Svensson, Dorothea Nagel, Carlos J Crespo, Hermann Brenner, Juan R Albertorio-Diaz, Robert Atkins, Eric J Brunner, Martin Shipley, Inger Njølstad, Deborah A Lawlor, Yvonne T van der Schouw, Randi Marie Selmer, Maurizio Trevisan, WM Monique Verschuren, Philip Greenland, Sylvia Wassertheil-Smoller, Gordon DO Lowe, Angela M Wood, Adam S Butterworth, Simon G Thompson, John Danesh, Emanuele Di Angelantonio, Tom Meade, Emerging Risk Factors Collaboration
Feb 11, 2019
The Association Between Parity and Subsequent Cardiovascular Disease in Women
Clare Oliver-Williams, Catherine J Vladutiu, Laura R Loehr, Wayne D Rosamond, Alison M Stuebe
Apr 11, 2019
breastfeeding cardiovascular disease Pregnancy Black or African American Breast Feeding Cardiovascular Diseases Cohort Studies Coronary Disease Female Follow-Up Studies Heart Failure Humans Middle Aged Myocardial Infarction Parity Pregnancy Pregnancy Outcome Proportional Hazards Models Risk Factors stroke United States White People
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
W Zhao, A Rasheed, E Tikkanen, J-J Lee, AS Butterworth, JMM Howson, TL Assimes, R Chowdhury, M Orho-Melander, S Damrauer, A Small, S Asma, M Imamura, T Yamauch, JC Chambers, P Chen, BR Sapkota, N Shah, S Jabeen, P Surendran, Y Lu, W Zhang, A Imran, S Abbas, F Majeed, K Trindade, N Qamar, NH Mallick, Z Yaqoob, T Saghir, SNH Rizvi, A Memon, SZ Rasheed, F-U-R Memon, K Mehmood, N Ahmed, IH Qureshi, Tanveer-Us-Salam, W Iqbal, U Malik, N Mehra, JZ Kuo, WH-H Sheu, X Guo, CA Hsiung, J-MJ Juang, KD Taylor, Y-J Hung, W-J Lee, T Quertermous, I-T Lee, C-C Hsu, EP Bottinger, S Ralhan, YY Teo, T-D Wang, DS Alam, E Di Angelantonio, S Epstein, SF Nielsen, BG Nordestgaard, A Tybjaerg-Hansen, R Young, CHD Exome+ Consortium, M Benn, R Frikke-Schmidt, PR Kamstrup, EPIC-CVD Consortium, EPIC-InterAct Consortium, Michigan Biobank, JW Jukema, N Sattar, R Smit, R-H Chung, K-W Liang, S Anand, DK Sanghera, S Ripatti, RJF Loos, JS Kooner, ES Tai, JI Rotter, Y-DI Chen, P Frossard, S Maeda, T Kadowaki, M Reilly, G Pare, O Melander, V Salomaa, DJ Rader, J Danesh, BF Voight, D Saleheen
Nov 21, 2017
Asia Asian People Biomarkers Comorbidity Coronary Disease Diabetes mellitus Type 2 Europe Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study HLA-DRB5 Chains Humans Metabolic Networks and Pathways Metabolic Syndrome Molecular Targeted Therapy Mutation Missense Polymorphism Single Nucleotide Risk Factors White People
A robust and efficient method for Mendelian randomization with hundreds of genetic variants.
Mendelian randomization (MR) is an epidemiological technique that uses genetic variants to distinguish correlation from causation in observational data. The reliability of a MR investigation depends on the validity of the...
Body Mass Index Cholesterol HDL Cholesterol LDL Coronary Disease Diabetes mellitus Type 2 Genetic Association Studies Genetic Pleiotropy Genetic Predisposition to Disease genetic variation Humans Mendelian Randomization Analysis Models Genetic molecular epidemiology Phenotype Reproducibility of Results Research Design Risk Factors Triglycerides
An Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors.
Eric L Harshfield, Albert Koulman, Daniel Ziemek, Luke Marney, Eric B Fauman, Dirk S Paul, David Stacey, Asif Rasheed, Jung-Jin Lee, Nabi Shah, Sehrish Jabeen, Atif Imran, Shahid Abbas, Zoubia Hina, Nadeem Qamar, Nadeem Hayyat Mallick, Zia Yaqoob, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Irshad Hussain Qureshi, Muhammad Ishaq, Philippe Frossard, John Danesh, Danish Saleheen, Adam S Butterworth, Angela M Wood, Julian L Griffin
Mar 28, 2019
Direct infusion high-resolution mass spectrometry (DIHRMS) is a novel, high-throughput approach to rapidly and accurately profile hundreds of lipids in human serum without prior chromatography, facilitating in-depth lipid...
Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease.
Gina M Peloso, Akihiro Nomura, Amit V Khera, Mark Chaffin, Hong-Hee Won, Diego Ardissino, John Danesh, Heribert Schunkert, James G Wilson, Nilesh Samani, Jeanette Erdmann, Ruth McPherson, Hugh Watkins, Danish Saleheen, Shane McCarthy, Tanya M Teslovich, Joseph B Leader, H Lester Kirchner, Jaume Marrugat, Atsushi Nohara, Masa-Aki Kawashiri, Hayato Tada, Frederick E Dewey, David J Carey, Aris Baras, Sekar Kathiresan
Apr 15, 2019
Interpretation of the evidence for the efficacy and safety of statin therapy.
Rory Collins, Christina Reith, Jonathan Emberson, Jane Armitage, Colin Baigent, Lisa Blackwell, Roger Blumenthal, John Danesh, George Davey Smith, David DeMets, Stephen Evans, Malcolm Law, Stephen MacMahon, Seth Martin, Bruce Neal, Neil Poulter, David Preiss, Paul Ridker, Ian Roberts, Anthony Rodgers, Peter Sandercock, Kenneth Schulz, Peter Sever, John Simes, Liam Smeeth, Nicholas Wald, Salim Yusuf, Richard Peto
Nov 22, 2017
This Review is intended to help clinicians, patients, and the public make informed decisions about statin therapy for the prevention of heart attacks and strokes. It explains how the evidence that is available from randomised...
Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22.
Katherine E Beaney, Andrew JP Smith, Lasse Folkersen, Jutta Palmen, S Goya Wannamethee, Barbara J Jefferis, Peter Whincup, Tom R Gaunt, Juan P Casas, Yoav Ben-Shlomo, Jacqueline F Price, Meena Kumari, Andrew Wong, Ken Ong, Rebecca Hardy, Diana Kuh, Nicholas Wareham, Mika Kivimaki, Per Eriksson, Steve E Humphries, Ucleb Consortium
Aug 16, 2017
Background. The coronary heart disease (CHD) risk locus on 21q22 (lead SNP rs9982601) lies within a "gene desert." The aim of this study was to assess if this locus is associated with CHD risk factors and to identify the...
The Bangladesh Risk of Acute Vascular Events (BRAVE) Study
Rajiv Chowdhury, Dewan S Alam, Ismail Ibrahim Fakir, Sheikh Daud Adnan, Aliya Naheed, Ishrat Tasmin, Md Mostafa Monower, Farzana Hossain, Fatema Mahjabin Hossain, Md Mostafizur Rahman, Sadia Afrin, Anjan Kumar Roy, Minara Akter, Sima Akter Sume, Ajoy Kumer Biswas, Lisa Pennells, Praveen Surendran, Robin D Young, Sarah A Spackman, Khaled Hasan, Eric Harshfield, Nasir Sheikh, Richard Houghton, Danish Saleheen, Joanna MM Howson, Adam S Butterworth, Cardiology Research Group, Rubhana Raqib, Abdulla Al Shafi Majumder, John Danesh, Emanuele Di Angelantonio
Jun 05, 2015
M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation.
Wenhua Yan, Tianhan Li, Tieying Yin, Zhengjun Hou, Kai Qu, Nan Wang, Colm Durkan, Lingqing Dong, Juhui Qiu, Hans Gregersen, Guixue Wang
Nov 09, 2020
Rationale: For intravascular stent implantation to be successful, the processes of vascular tissue repair and therapy are considered to be critical. However, the mechanisms underlying the eventual fate of vascular smooth muscle...
M2 macrophage Dedifferentiation Exosomes intravascular stent Stiffness vascular smooth muscle cell Animals Cell Communication Cell Differentiation Cell Line Coronary Disease Disease Models Animal Endovascular Procedures Exosomes Humans MACROPHAGES Male Muscle Smooth Vascular Myocytes Smooth Muscle Neointima Proto-Oncogene Proteins c-jun Proto-Oncogene Proteins c-kit RNA-seq Rats Rats Sprague-Dawley Signal Transduction Stents Transcription Factor AP-1
Assessing the causal association of glycine with risk of cardio-metabolic diseases.
Laura BL Wittemans, Luca A Lotta, Clare Oliver-Williams, Isobel D Stewart, Praveen Surendran, Savita Karthikeyan, Felix R Day, Albert Koulman, Fumiaki Imamura, Lingyao Zeng, Jeanette Erdmann, Heribert Schunkert, Kay-Tee Khaw, Julian L Griffin, Nita G Forouhi, Robert A Scott, Angela M Wood, Stephen Burgess, Joanna MM Howson, John Danesh, Nicholas J Wareham, Adam S Butterworth, Claudia Langenberg
Feb 18, 2019
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