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Winter is coming
Sanja Bojic, Alex Murray, Barry L Bentley, Ralf Spindler, Piotr Pawlik, José L Cordeiro, Roman Bauer, João Pedro de Magalhães
Mar 24, 2021
The preservative effects of low temperature on biological materials have been long recognised, and cryopreservation is now widely used in biomedicine, including in organ transplantation, regenerative medicine and drug discovery....
Human leukemia cells (HL-60) proteomic and biological signatures underpinning cryo-damage are differentially modulated by novel cryo-additives.
Noha AS Al-Otaibi, Juliana S Cassoli, Daniel Martins-de-Souza, Nigel Kh Slater, Hassan Rahmoune
Feb 07, 2019
BACKGROUND: Cryopreservation is a routinely used methodology for prolonged storage of viable cells. The use of cryo-protective agents (CPAs) such as dimethylsulfoxide (DMSO), glycerol, or trehalose is paramount to reducing...
Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets.
Nikola Dolezalova, Anja Gruszczyk, Kerry Barkan, John A Gamble, Sam Galvin, Till Moreth, Kevin O'Holleran, Krishnaa T Mahbubani, Jackie A Higgins, Fiona M Gribble, Frank Reimann, Jakub Surmacki, Simon Andrews, John J Casey, Francesco Pampaloni, Michael P Murphy, Graham Ladds, Nigel Kh Slater, Kourosh Saeb-Parsy
May 24, 2021
Cryopreservation offers the potential to increase the availability of pancreatic islets for treatment of diabetic patients. However, current protocols, which use dimethyl sulfoxide (DMSO), lead to poor cryosurvival of islets. We...
Increased cryosurvival of osteosarcoma cells using an amphipathic pH-responsive polymer for trehalose uptake.
Cryopreservation of Human Adipose Tissues and Adipose-Derived Stem Cells with DMSO and/or Trehalose
Adipose tissue senescence is implicated as a major player in obesity- and ageing-related disorders. There is a growing body of research studying relevant mechanisms in age-related diseases, as well as the use of adipose-derived...